PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32955829-1 2020 The isocitrate dehydrogenases enzymes, IDH1 and IDH2, catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG) in the cell cytoplasm and mitochondria, respectively, and contribute to generating the dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as reductive potential in different cellular processes. isocitric acid 4-14 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 48-52 31257503-9 2019 Finally, [U-13C5]glutamine tracer analysis showed that IDH2 knockdown reduced the reductive carboxylation of alpha-KG into isocitrate in HCT116R132H/+ cells under hypoxic conditions. isocitric acid 123-133 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 55-59 32777735-3 2020 Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG). isocitric acid 164-174 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 44-48 31105869-1 2019 The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to alpha-ketoglutarate. isocitric acid 14-24 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 99-103 29773061-1 2018 Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG). isocitric acid 108-118 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 44-48 30013764-3 2018 IDH2 enzyme is involved in the Krebs cycle, catalyzing alpha-ketoglutarate from isocitrate. isocitric acid 80-90 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 30506321-1 2018 Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate. isocitric acid 88-98 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 43-47 29769206-4 2018 IDH2 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate; its mutated version leads to the accumulation of the oncometabolite (R)-2 hydroxyglutarate, which disrupts several cell processes and leads to a blockage in differentiation. isocitric acid 66-76 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 28536275-1 2017 The isocitrate dehydrogenase IDH2 produces alpha-ketoglutarate by oxidizing isocitrate, linking glucose metabolism to oxidative phosphorylation. isocitric acid 4-14 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 29-33 29290954-6 2017 IDH2 catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG), an essential cofactor for the TET family of 5-methylcytosine (5mC) hydroxylases that convert 5-mC to 5-hydroxymethylcytosine (5-hmC). isocitric acid 48-58 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 27621679-1 2016 Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate. isocitric acid 88-98 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 43-47 27721426-5 2017 Both IDH2 and IDH1 (localized in the cytoplasm) proteins catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). isocitric acid 99-109 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 5-9 27049945-10 2016 Isotope tracing revealed that in spheroids, isocitrate/citrate produced reductively in the cytosol could enter the mitochondria and participate in oxidative metabolism, including oxidation by IDH2. isocitric acid 44-54 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 192-196 26819452-1 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. isocitric acid 70-80 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 26819452-1 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. isocitric acid 70-80 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 209-213 27005468-1 2016 Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to alpha-ketoglutarate (alphaKG).IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). isocitric acid 87-97 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 43-47 27005468-1 2016 Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to alpha-ketoglutarate (alphaKG).IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). isocitric acid 87-97 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 140-144 24880135-5 2014 In their wild-type forms, IDH1 and IDH2 convert isocitrate and NADP(+) to alpha-ketoglutarate (alphaKG) and NADPH. isocitric acid 48-58 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 35-39 26188014-3 2016 IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG). isocitric acid 53-63 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 167-171 26960449-4 2016 While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG). isocitric acid 62-72 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 15-19 26960449-4 2016 While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG). isocitric acid 62-72 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 122-126 25753205-2 2015 Although IDH2 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in mitochondria, mutated IDH2 proteins possess the ability to change alpha-KG into the oncometabolite R(-)-2-hydroxyglutarate (2-HG). isocitric acid 55-65 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 25753205-2 2015 Although IDH2 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in mitochondria, mutated IDH2 proteins possess the ability to change alpha-KG into the oncometabolite R(-)-2-hydroxyglutarate (2-HG). isocitric acid 55-65 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 125-129 25324168-3 2015 IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in the cytosol and mitochondria, respectively. isocitric acid 54-64 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 23630074-2 2013 IDH1 and IDH2 catalyze the interconversion of isocitrate and 2-oxoglutarate (2OG). isocitric acid 46-56 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 22343896-4 2012 IDH1 and IDH2, which catalyse the interconversion of isocitrate and 2-OG, are frequently mutated in human brain tumours and leukaemias. isocitric acid 53-63 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 9-13 23226729-1 2012 IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production. isocitric acid 60-70 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 22397365-1 2012 BACKGROUND: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate. isocitric acid 152-162 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 55-59 21889589-2 2011 Overexpression studies with IDH1(R132H) and IDH2(R172K) mutations demonstrated that the enzymes acquired a new function, converting 2-ketoglutarate (2-KG) to d-2-hydroxyglutarate (D-2-HG), in lieu of the normal IDH reaction which reversibly converts isocitrate to 2-KG. isocitric acid 250-260 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 44-48 22106302-6 2011 Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondrial isocitrate dehydrogenase (IDH2) to form isocitrate, which can then be isomerized to citrate. isocitric acid 100-110 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 126-130 20603105-1 2010 Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH). isocitric acid 38-48 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 66-70 20972461-3 2010 Soon, it became clear that the mutations identified impaired the ability of IDH1 and IDH2 to catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG), whereas conferring a gain of a novel enzymatic activity leading to the reduction of alphaKG to the metabolite D2-hydroxyglutarate (D-2HG). isocitric acid 120-130 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 85-89 21647154-5 2011 Structural modeling of IDH2 suggested that codon 140 mutations disrupt the enzyme"s ability to bind its substrate isocitrate. isocitric acid 114-124 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 23-27 21647154-6 2011 Accordingly, recombinant IDH2 R140Q/W were unable to carry out the decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG), but instead gained the neomorphic activity to reduce alpha-KG to R(-)-2-hydroxyglutarete (2-HG). isocitric acid 86-96 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 25-29 19996293-2 2009 All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). isocitric acid 79-89 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 151-155