PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33028985-4 2021 In lipopolysaccharides (LPS)-stimulated mouse bone marrow-derived macrophages (BMDMs), Tan-IIA (10 muM) significantly decreased succinate-boosted IL-1beta and IL-6 production, accompanied by upregulation of IL-1RA and IL-10 release via inhibiting succinate dehydrogenase (SDH). Succinic Acid 128-137 aminoadipate-semialdehyde synthase Mus musculus 247-270 34425095-12 2021 miR-144 silencing selectively reduced the activities of both SDH and FH resulting in the accumulation of their related substrates succinate and fumarate. Succinic Acid 130-139 aminoadipate-semialdehyde synthase Mus musculus 61-64 35472723-5 2022 Mechanistically, metabolomic and transcriptomic studies reveal that the loss of SDH causes excess succinate accumulation, which inappropriately activates mTORC1-regulated metabolic anabolism, including increased SREBP-regulated lipid synthesis. Succinic Acid 98-107 aminoadipate-semialdehyde synthase Mus musculus 80-83 35351859-7 2022 Succinate levels were significantly reduced following treatment with inhibitors of succinate dehydrogenase (SDH), purine nucleotide cycle (PNC), and malate/aspartate shuttle (MAS), with the corresponding attenuation of oxidative stress, iron stress, neuronal damage, and cognitive impairment. Succinic Acid 0-9 aminoadipate-semialdehyde synthase Mus musculus 83-106 35351859-7 2022 Succinate levels were significantly reduced following treatment with inhibitors of succinate dehydrogenase (SDH), purine nucleotide cycle (PNC), and malate/aspartate shuttle (MAS), with the corresponding attenuation of oxidative stress, iron stress, neuronal damage, and cognitive impairment. Succinic Acid 0-9 aminoadipate-semialdehyde synthase Mus musculus 108-111 35351859-8 2022 Reversal catalysis of SDH through fumarate from the PNC and MAS pathways might be involved in hypoxia-induced succinate accumulation. Succinic Acid 110-119 aminoadipate-semialdehyde synthase Mus musculus 22-25 15992781-1 2005 In this study we investigated whether succinate, the accumulating substrate in succinate dehydrogenase (SDH) deficiencies and SDH inhibitor intoxication, causes lipoperoxidation and protein carbonylation, and if NMDA receptors are involved in the succinate-induced oxidative damage. Succinic Acid 38-47 aminoadipate-semialdehyde synthase Mus musculus 79-102 15992781-1 2005 In this study we investigated whether succinate, the accumulating substrate in succinate dehydrogenase (SDH) deficiencies and SDH inhibitor intoxication, causes lipoperoxidation and protein carbonylation, and if NMDA receptors are involved in the succinate-induced oxidative damage. Succinic Acid 38-47 aminoadipate-semialdehyde synthase Mus musculus 104-107 15992781-1 2005 In this study we investigated whether succinate, the accumulating substrate in succinate dehydrogenase (SDH) deficiencies and SDH inhibitor intoxication, causes lipoperoxidation and protein carbonylation, and if NMDA receptors are involved in the succinate-induced oxidative damage. Succinic Acid 38-47 aminoadipate-semialdehyde synthase Mus musculus 126-129 15992781-7 2005 These results suggest the involvement of NMDA receptors in these effects of succinate, which may of particular relevance for succinate-accumulating conditions, such as SDH inhibitors intoxication and inherited SDH deficiencies. Succinic Acid 76-85 aminoadipate-semialdehyde synthase Mus musculus 168-171 33028985-4 2021 In lipopolysaccharides (LPS)-stimulated mouse bone marrow-derived macrophages (BMDMs), Tan-IIA (10 muM) significantly decreased succinate-boosted IL-1beta and IL-6 production, accompanied by upregulation of IL-1RA and IL-10 release via inhibiting succinate dehydrogenase (SDH). Succinic Acid 128-137 aminoadipate-semialdehyde synthase Mus musculus 272-275 32648168-2 2022 During ischemia, succinate accumulates and its oxidation upon reperfusion by succinate dehydrogenase (SDH) drives ROS production. Succinic Acid 17-26 aminoadipate-semialdehyde synthase Mus musculus 77-100 33023985-6 2020 The decrease in SDH levels in tumor cells resulted in an accumulation of succinate, which enhanced the stability of the transcription factor HIF1alpha and reprogrammed cell metabolism to a glycolytic state. Succinic Acid 73-82 aminoadipate-semialdehyde synthase Mus musculus 16-19 33666092-4 2021 Current evidence suggests that elevated ROS production in ischemic tissues occurs due to accumulation of the mitochondrial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rapidly oxidized at reperfusion. Succinic Acid 134-143 aminoadipate-semialdehyde synthase Mus musculus 164-187 33666092-4 2021 Current evidence suggests that elevated ROS production in ischemic tissues occurs due to accumulation of the mitochondrial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rapidly oxidized at reperfusion. Succinic Acid 134-143 aminoadipate-semialdehyde synthase Mus musculus 189-192 33666092-4 2021 Current evidence suggests that elevated ROS production in ischemic tissues occurs due to accumulation of the mitochondrial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rapidly oxidized at reperfusion. Succinic Acid 164-173 aminoadipate-semialdehyde synthase Mus musculus 189-192 32648168-2 2022 During ischemia, succinate accumulates and its oxidation upon reperfusion by succinate dehydrogenase (SDH) drives ROS production. Succinic Acid 17-26 aminoadipate-semialdehyde synthase Mus musculus 102-105 32648168-3 2022 Inhibition of succinate accumulation and/or oxidation by dimethyl malonate (DMM), a cell permeable prodrug of the SDH inhibitor malonate, can decrease I/R injury. Succinic Acid 14-23 aminoadipate-semialdehyde synthase Mus musculus 114-117 32046101-13 2020 However, inhibition of SDH can lead to the accumulation of succinate, an important signaling molecule associated with inflammation, fibrosis, and carcinogenesis. Succinic Acid 59-68 aminoadipate-semialdehyde synthase Mus musculus 23-26 29464059-2 2018 SDH loss leads to accumulation of intracellular succinate, which competitively inhibits dioxygenase enzymes, causing activation of pseudohypoxic signaling and hypermethylation of histones and DNA. Succinic Acid 48-57 aminoadipate-semialdehyde synthase Mus musculus 0-3 30159755-6 2018 Sdhb-silenced cells showed functional impairment of SDH with elevated succinate to fumarate ratio and decreased oxidative capacity. Succinic Acid 70-79 aminoadipate-semialdehyde synthase Mus musculus 52-55 28634116-3 2017 In neurons, oxygen-glucose deprivation induced succinate accumulation due to the reversal of succinate dehydrogenase (SDH) activation, leading to mitochondrial fission. Succinic Acid 47-56 aminoadipate-semialdehyde synthase Mus musculus 93-116 28634116-3 2017 In neurons, oxygen-glucose deprivation induced succinate accumulation due to the reversal of succinate dehydrogenase (SDH) activation, leading to mitochondrial fission. Succinic Acid 47-56 aminoadipate-semialdehyde synthase Mus musculus 118-121 26302408-1 2015 Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Succinic Acid 109-118 aminoadipate-semialdehyde synthase Mus musculus 0-23 26302408-1 2015 Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Succinic Acid 109-118 aminoadipate-semialdehyde synthase Mus musculus 25-28 26051274-6 2015 Malonate, an inhibitor of succinate dehydrogenase (SDH), increased succinate levels in cultured HSCs and increased GPR91 and alpha-SMA expression. Succinic Acid 26-35 aminoadipate-semialdehyde synthase Mus musculus 51-54 27667687-3 2016 We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production. Succinic Acid 50-59 aminoadipate-semialdehyde synthase Mus musculus 64-87 27667687-3 2016 We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production. Succinic Acid 50-59 aminoadipate-semialdehyde synthase Mus musculus 89-92 26912655-3 2016 Moreover, SIRT3 is a key regulator of succinate dehydrogenase (SDH), which catalyzes the oxidation of succinate to fumarate. Succinic Acid 38-47 aminoadipate-semialdehyde synthase Mus musculus 63-66 26912655-7 2016 Inhibiting SIRT3 using SIRT3 siRNA exacerbated HSC activation via the SDH-succinate-GPR91 pathway, and SIRT3 overexpression or honokiol treatment attenuated HSC activation in vitro In isolated liver and HSCs from methionine- and choline-deficient (MCD) diet-induced NAFLD, the expression of SIRT3 and SDH activity was decreased, and the succinate concentrations and GPR91 expression were increased. Succinic Acid 74-83 aminoadipate-semialdehyde synthase Mus musculus 70-73 25874444-2 2015 Mitochondrial succinate dehydrogenase (SDH) fulfils a dual function with respect to mitochondrial energy supply: (1) the enzyme is part of mitochondrial respiratory chains; and (2) it catalyses oxidation of succinate to fumarate in the Krebs cycle. Succinic Acid 14-23 aminoadipate-semialdehyde synthase Mus musculus 39-42