PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7601424-9 1995 Although proliferation of hepatocytes in low-serum decreased by 75%, the appearance of apoptosis in the presence of PB was associated with increased expression of the c-myc gene. Phenobarbital 116-118 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 167-172 7576107-0 1995 Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital. Phenobarbital 129-142 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 14-19 7487997-0 1995 Nuclear matrix condensation and c-myc and c-fos expression are specifically altered in culture rat hepatocytes after exposure to cyproterone acetate and phenobarbital. Phenobarbital 153-166 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 32-37 3121722-1 1988 This study examined the possibility of using an immunohistochemical technique to detect the expression of myc and src oncogene proteins (ops) in livers of male Sprague-Dawley rats after treatment with the carcinogen diethylnitrosamine (with or without phenobarbital promotion) or untreated. Phenobarbital 252-265 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 106-109 22358698-0 1993 Thein utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression ofc-jun andc-myc oncogenes in primary neonatal rat hepatocytes. Phenobarbital 102-115 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 148-151 2647284-0 1989 Over expression of proto-oncogenes: ki-ras, fos and myc in rat liver cells treated in vitro by two liver tumor promoters: phenobarbital and biliverdin. Phenobarbital 122-135 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 52-55 7540119-3 1995 It was also demonstrated that tumor promoter phenobarbital influenced c-fos and c-myc expressions and decreased alpha 1I3 mRNA level in rat liver during a long term experiment. Phenobarbital 45-58 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 80-85 7763748-0 1993 The in utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression of c-jun and c-myc oncogenes in primary neonatal rat hepatocytes. Phenobarbital 103-116 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 149-154 3335004-4 1988 There was a considerable increase (4- to 5-fold) in the level of c-myc transcripts, at 12 and 48 h after partial hepatectomy in the phenobarbital-treated rats, and at 12 and 24 h in the rats on the control diet. Phenobarbital 132-145 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 65-70 30141584-0 2018 Hypomethylation of the c-myc promoter region induced by phenobarbital in rat liver Background: The changes in DNA methylation are considered as one of the early events in hepatocarcinogenesis. Phenobarbital 56-69 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 23-28 30141584-1 2018 Objective: We evaluated the ability of phenobarbital (PB) - the most widely used anticonvulsant worldwide and classical rodent liver carcinogen - to cause the promoter region of the c-myc protooncogene hypomethylation as well as changes of mRNA level of this gene. Phenobarbital 39-52 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 182-187 30141584-1 2018 Objective: We evaluated the ability of phenobarbital (PB) - the most widely used anticonvulsant worldwide and classical rodent liver carcinogen - to cause the promoter region of the c-myc protooncogene hypomethylation as well as changes of mRNA level of this gene. Phenobarbital 54-56 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 182-187 30141584-7 2018 Results: The study showed that phenobarbital stimulated persistent changes in DNA methylation, i.e. loss of methylation inthe promoter region of the c-myc gene and up-regulated its mRNA level. Phenobarbital 31-44 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 149-154 30141584-10 2018 The c-myc over-expression by demethylation might represent an important, early events in the mechanism of action (MOA) of phenobarbital. Phenobarbital 122-135 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 4-9