PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7601424-9	1995	Although proliferation of hepatocytes in low-serum decreased by 75%, the appearance of apoptosis in the presence of PB was associated with increased expression of the c-myc gene.	Phenobarbital	116-118	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	167-172	
7576107-0	1995	Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.	Phenobarbital	129-142	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	14-19	
7487997-0	1995	Nuclear matrix condensation and c-myc and c-fos expression are specifically altered in culture rat hepatocytes after exposure to cyproterone acetate and phenobarbital.	Phenobarbital	153-166	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	32-37	
3121722-1	1988	This study examined the possibility of using an immunohistochemical technique to detect the expression of myc and src oncogene proteins (ops) in livers of male Sprague-Dawley rats after treatment with the carcinogen diethylnitrosamine (with or without phenobarbital promotion) or untreated.	Phenobarbital	252-265	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	106-109	
22358698-0	1993	Thein utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression ofc-jun andc-myc oncogenes in primary neonatal rat hepatocytes.	Phenobarbital	102-115	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	148-151	
2647284-0	1989	Over expression of proto-oncogenes: ki-ras, fos and myc in rat liver cells treated in vitro by two liver tumor promoters: phenobarbital and biliverdin.	Phenobarbital	122-135	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	52-55	
7540119-3	1995	It was also demonstrated that tumor promoter phenobarbital influenced c-fos and c-myc expressions and decreased alpha 1I3 mRNA level in rat liver during a long term experiment.	Phenobarbital	45-58	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	80-85	
7763748-0	1993	The in utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression of c-jun and c-myc oncogenes in primary neonatal rat hepatocytes.	Phenobarbital	103-116	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	149-154	
3335004-4	1988	There was a considerable increase (4- to 5-fold) in the level of c-myc transcripts, at 12 and 48 h after partial hepatectomy in the phenobarbital-treated rats, and at 12 and 24 h in the rats on the control diet.	Phenobarbital	132-145	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	65-70	
30141584-0	2018	Hypomethylation of the c-myc promoter region induced by phenobarbital in rat liver Background: The changes in DNA methylation are considered as one of the early events in hepatocarcinogenesis.	Phenobarbital	56-69	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	23-28	
30141584-1	2018	Objective: We evaluated the ability of phenobarbital (PB) - the most widely used anticonvulsant worldwide and classical rodent liver carcinogen - to cause the promoter region of the c-myc protooncogene hypomethylation as well as changes of mRNA level of this gene.	Phenobarbital	39-52	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	182-187	
30141584-1	2018	Objective: We evaluated the ability of phenobarbital (PB) - the most widely used anticonvulsant worldwide and classical rodent liver carcinogen - to cause the promoter region of the c-myc protooncogene hypomethylation as well as changes of mRNA level of this gene.	Phenobarbital	54-56	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	182-187	
30141584-7	2018	Results: The study showed that phenobarbital stimulated persistent changes in DNA methylation, i.e. loss of methylation inthe promoter region of the c-myc gene and up-regulated its mRNA level.	Phenobarbital	31-44	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	149-154	
30141584-10	2018	The c-myc over-expression by demethylation might represent an important, early events in the mechanism of action (MOA) of phenobarbital.	Phenobarbital	122-135	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	4-9