PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16839222-8	2006	In conclusion, PB at high dose enhances DEN-induced hepatocarcinogenesis in TGF-alpha transgenic mice, but low doses lack any significant effects.	Phenobarbital	15-17	transforming growth factor alpha	Mus musculus	76-85	
14742323-0	2004	Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.	Phenobarbital	126-139	transforming growth factor alpha	Mus musculus	83-92	
14742323-2	2004	Given that PB selectively promoted initiated cells harboring beta-catenin mutations during chemically induced hepatocarcinogenesis and that Wnt/beta-catenin signaling is involved in both anti-apoptotic and proliferative processes, we now have extended our analysis to investigate whether promotion by PB affects the occurrence of beta-catenin mutations in c-myc/TGF-alpha-driven tumors.	Phenobarbital	11-13	transforming growth factor alpha	Mus musculus	362-371	
14742323-3	2004	The frequency of beta-catenin activation as judged by somatic mutations and/or nuclear localization was significantly increased in hepatocellular carcinomas (HCCs) from c-myc/TGF-alpha mice treated with PB (15/28; 53.6%) as compared with that in control HCCs (2/28; 7.1%).	Phenobarbital	203-205	transforming growth factor alpha	Mus musculus	175-184	
14742323-8	2004	These findings show that PB treatment positively selects for a cell population displaying activation of beta-catenin in c-myc/TGF-alpha HCCs.	Phenobarbital	25-27	transforming growth factor alpha	Mus musculus	126-135	
11560253-2	2001	In this study, we investigated immunohistochemically the association between expression of TGF-alpha and cell proliferation activity in mouse hepatoblastomas (HBs) and hepatocellular carcinomas (HCCs) induced in B6C3F1 mice by diethylnitrosamine and sodium phenobarbital.	Phenobarbital	250-270	transforming growth factor alpha	Mus musculus	91-100	
10942533-0	2000	Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.	Phenobarbital	37-50	transforming growth factor alpha	Mus musculus	60-69	
10942533-9	2000	We believe that the PB-dependent modification of tumorigenesis in the livers of c-myc/TGF-alpha mice was predominantly a result of the ability of this drug to block cell death during the early stages of tumor development.	Phenobarbital	20-22	transforming growth factor alpha	Mus musculus	86-95	
9934848-0	1999	Phenobarbital promotes liver growth in c-myc/TGF-alpha transgenic mice by inducing hypertrophy and inhibiting apoptosis.	Phenobarbital	0-13	transforming growth factor alpha	Mus musculus	45-54	
9934848-13	1999	We conclude from our data that PB stimulates liver growth in double transgenic c-myc/TGF-alpha mice by induction of liver hypertrophy and inhibition of apoptosis, brought about by both a decrease in signaling through the TGF-beta pathway and an increase in Bcl-2.	Phenobarbital	31-33	transforming growth factor alpha	Mus musculus	85-94	
7923571-0	1994	Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.	Phenobarbital	223-236	transforming growth factor alpha	Mus musculus	39-71	
7923571-14	1994	In conclusion, TGF-alpha transgenic mice clearly demonstrated enhanced sensitivity to the development of hepatocellular carcinoma in the DEN initiation and PB promotion regime, possibly through a mechanism of increased hepatocyte proliferation in precancerous lesions (foci and adenomas), driven by high expression of the mitogen TGF-alpha in these lesions.	Phenobarbital	156-158	transforming growth factor alpha	Mus musculus	15-24	
8364928-7	1993	These results demonstrate that chemical agents as diverse as nitrosamines and phenobarbital act as cocarcinogens with TGF-alpha in the livers of these transgenic mice, indicating that TGF-alpha possesses the unique ability to complement both initiation and promotion in hepatocarcinogenesis.	Phenobarbital	78-91	transforming growth factor alpha	Mus musculus	118-127	
8364928-7	1993	These results demonstrate that chemical agents as diverse as nitrosamines and phenobarbital act as cocarcinogens with TGF-alpha in the livers of these transgenic mice, indicating that TGF-alpha possesses the unique ability to complement both initiation and promotion in hepatocarcinogenesis.	Phenobarbital	78-91	transforming growth factor alpha	Mus musculus	184-193