PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2299585-9 1990 The most likely mechanisms for the effects observed are 1) inhibition of acetaminophen reactive metabolite formation in 3-methylcholanthrene-induced animals by each of the methylxanthines, and 2) activation of the phenobarbital-inducible forms of cytochrome(s) P-450 toward formation of acetaminophen reactive metabolites by caffeine and theophylline, but not theobromine. Phenobarbital 214-227 VPS52 subunit of GARP complex Rattus norvegicus 52-57