PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9806796-3 1998 The addition of 5 nM insulin to hepatocytes culture led to a significant decrease of both basal and phenobarbital-induced ALA-S mRNA in a dose-dependent manner, as measured by Northern and slot-blot analysis. Phenobarbital 100-113 insulin Homo sapiens 21-28 9806796-8 1998 Our results demonstrate that the insulin effect is dominant; it overrides 8-CPT-cAMP plus phenobarbital-mediated induction. Phenobarbital 90-103 insulin Homo sapiens 33-40 8139483-3 1994 In control rats receiving PB in drinking water (0.5 mg/mL), serum insulin and triglyceride levels were diminished without any change in glucose and cholesterol concentrations in the fed state. Phenobarbital 26-28 insulin Homo sapiens 66-73 9283635-3 1997 Phenobarbital, a hepatic enzyme inducer, has been used in the treatment of patients with non-insulin-dependent diabetes mellitus (NIDDM), increasing the insulin-mediated glucose disposal. Phenobarbital 0-13 insulin Homo sapiens 93-100 9283635-11 1997 These data indicate that phenobarbital activated some of the insulin-stimulated glucose metabolism steps which were depressed in diabetic erythrocytes, supporting the view that erythrocytes participate in glucose homeostasis. Phenobarbital 25-38 insulin Homo sapiens 61-68 8139483-4 1994 Administration of PB in drinking water (0.25 mg/mL) to both groups of diabetic rats decreased their water intake and serum triglyceride levels in the absence of an effect on glucose, insulin, and cholesterol concentrations in the fed state. Phenobarbital 18-20 insulin Homo sapiens 183-190 8139483-8 1994 In contrast, PB administration enhanced insulin-mediated peripheral glucose utilization, as well as suppression of hepatic glucose production, in both low-dose and high-dose diabetic groups. Phenobarbital 13-15 insulin Homo sapiens 40-47 34436456-9 2021 Here, we detail the formative hours of the insulin SG from the luminal perspective. Phenobarbital 63-70 insulin Homo sapiens 43-50 2171690-1 1990 Addition of phenobarbital, an inducer of the liver mixed function oxidase system, to sulphonylurea regimen improves insulin sensitivity and intracellular glucose handling in patients with non-insulin dependent diabetes mellitus. Phenobarbital 12-25 insulin Homo sapiens 116-123 34848728-4 2021 Mechanistically, WFS1 directly binds to vesicular cargo proteins including proinsulin via its ER luminal C-terminal segment, whereas pathogenic mutations within this region disrupt the interaction. Phenobarbital 97-104 insulin Homo sapiens 75-85 2697484-4 1989 Therapy with PB, but not placebo, reduced fasting IRI and BG in subjects with glucose intolerance and improved the glucose tolerance, insulin response to glucose and antipyrine metabolism. Phenobarbital 13-15 insulin Homo sapiens 134-141 2697484-5 1989 The effects of PB on patients with NIDDM were dependent on the insulin availability and duration of the disease. Phenobarbital 15-17 insulin Homo sapiens 63-70 6377421-0 1984 Phenobarbital treatment enhances insulin mediated glucose metabolism in man. Phenobarbital 0-13 insulin Homo sapiens 33-40 20253390-0 1947 The effect of phenobarbital on the action of insulin. Phenobarbital 14-27 insulin Homo sapiens 45-52 3896900-1 1985 The reduction in blood glucose in non-insulin-dependent diabetes mellitus (NIDDM) brought about by the use of phenobarbital (PB), a hepatic microsomal enzyme inducer, suggests an improvement in insulin sensitivity. Phenobarbital 110-123 insulin Homo sapiens 38-45 3896900-1 1985 The reduction in blood glucose in non-insulin-dependent diabetes mellitus (NIDDM) brought about by the use of phenobarbital (PB), a hepatic microsomal enzyme inducer, suggests an improvement in insulin sensitivity. Phenobarbital 125-127 insulin Homo sapiens 38-45 3896900-3 1985 The addition of PB to sulfonylurea therapy, concurrently for 6 wk, reduced fasting blood glucose (BG, from 12.8 +/- 1.6 to 10.2 +/- 3.2 mmol/L, P less than 0.01) and immunoreactive insulin (IRI) levels (from 32.4 +/- 13.6 to 24.7 +/- 9.8 mU/L, P less than 0.01), whereas body weight remained unaltered. Phenobarbital 16-18 insulin Homo sapiens 181-188 6851415-3 1983 These inducers (phenobarbital and medroxyprogesterone acetate) when added as adjuvant therapy to sulfonyl urea regimen, reduced blood glucose and plasma insulin, and increased microsomal enzyme activity (as indicated by increased antipyrine metabolism). Phenobarbital 16-29 insulin Homo sapiens 153-160 26994072-1 2016 Phenobarbital (PB) antagonized insulin to inactivate the insulin receptor and attenuated the insulin receptor downstream protein kinase B (AKT)-forkhead box protein O1 and extracellular signal-regulated kinase 1/2 signals in mouse primary hepatocytes and HepG2 cells. Phenobarbital 0-13 insulin Homo sapiens 31-38 26994072-1 2016 Phenobarbital (PB) antagonized insulin to inactivate the insulin receptor and attenuated the insulin receptor downstream protein kinase B (AKT)-forkhead box protein O1 and extracellular signal-regulated kinase 1/2 signals in mouse primary hepatocytes and HepG2 cells. Phenobarbital 0-13 insulin Homo sapiens 57-64 26994072-1 2016 Phenobarbital (PB) antagonized insulin to inactivate the insulin receptor and attenuated the insulin receptor downstream protein kinase B (AKT)-forkhead box protein O1 and extracellular signal-regulated kinase 1/2 signals in mouse primary hepatocytes and HepG2 cells. Phenobarbital 15-17 insulin Homo sapiens 31-38 26994072-1 2016 Phenobarbital (PB) antagonized insulin to inactivate the insulin receptor and attenuated the insulin receptor downstream protein kinase B (AKT)-forkhead box protein O1 and extracellular signal-regulated kinase 1/2 signals in mouse primary hepatocytes and HepG2 cells. Phenobarbital 15-17 insulin Homo sapiens 57-64 23055876-5 2008 RESULTS: THE FOLLOWING DRUGS WERE DEEMED COMPATIBLE WITH IBUPROFEN LYSINE: ceftazidime, epinephrine, furosemide, heparin lock flush, diluted insulin, morphine sulfate, phenobarbital, potassium chloride, and sodium bicarbonate. Phenobarbital 168-181 insulin Homo sapiens 141-148