PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16421288-9 2006 Cotreatment of animals with PB and E(2) increased activities of NAD(P)H:quinone oxidoreductase and glutathione S-transferase to a greater extent than either compound alone. Phenobarbital 28-30 hematopoietic prostaglandin D synthase Rattus norvegicus 99-124 24650251-2 2014 Administration of rats with DEN and PB caused an elevation in the levels of malondialde-hyde (MDA), DNAF, and activities of glutathione reductase (GSR) and caspase-3, while the activities of superoxide dismutase, glutathione S-transferase, total glutathione peroxidase (t-GPx), and glutathione (GSH) level were decreased in hepatocytes compared to the control. Phenobarbital 36-38 hematopoietic prostaglandin D synthase Rattus norvegicus 213-238 21445586-3 2011 The PB-induced increase in the number and area of glutathione S-transferase placental form-positive foci and the proliferating cell nuclear antigen-positive ratio was significantly suppressed by EMIQ. Phenobarbital 4-6 hematopoietic prostaglandin D synthase Rattus norvegicus 50-75 18616970-2 2008 A PB promoting regimen (0.05% in the diet) stimulated the outgrowth of FB(1)-induced placental glutathione S-transferase (GSTP) positive initiated hepatocytes. Phenobarbital 2-4 hematopoietic prostaglandin D synthase Rattus norvegicus 95-120 17658503-17 2007 The liver and erythrocyte glutathione-S-transferase (GST) activity increased in all the groups treated with NDEA and PB. Phenobarbital 117-119 hematopoietic prostaglandin D synthase Rattus norvegicus 26-51 17658503-17 2007 The liver and erythrocyte glutathione-S-transferase (GST) activity increased in all the groups treated with NDEA and PB. Phenobarbital 117-119 hematopoietic prostaglandin D synthase Rattus norvegicus 53-56 17306917-5 2007 As with the PB-promoted case, both numbers and areas of glutathione S-transferase placental form-positive liver cell foci were significantly increased by JQE at 30,000 ppm, with non-significant increases evident at 5000 ppm. Phenobarbital 12-14 hematopoietic prostaglandin D synthase Rattus norvegicus 56-81 8801059-4 1996 An elevation of GST activities by 45 to 100% was observed after pretreatment of rats with phenobarbital (PB). Phenobarbital 90-103 hematopoietic prostaglandin D synthase Rattus norvegicus 16-19 15151625-7 2004 RESULTS: It was observed that in the DEN-treated and PB-promoted group (group A) the expression of the numbers and areas of the placental form of glutathione S-transferase (GST-P)-positive altered hepatic foci (AHF) was maximum. Phenobarbital 53-55 hematopoietic prostaglandin D synthase Rattus norvegicus 146-171 11191639-5 2000 The expression of the number and area of altered hepatocyte foci (AHF) positive for placental glutathione S-transferase (GST-P) was maximum in DEN-treated and PB promoted group (Group A). Phenobarbital 159-161 hematopoietic prostaglandin D synthase Rattus norvegicus 94-119 10817630-4 2000 Phenobarbital (PB) administration (0.1% in drinking water; 15 days) elicited an enhancement in liver microsomal functions, lipid peroxidation, and GSH content, without changes in oxidative stress-related enzymatic activities, except for the elevation in those of glutathione reductase and glutathione-S-transferase, compared to control rats. Phenobarbital 0-13 hematopoietic prostaglandin D synthase Rattus norvegicus 289-314 10817630-4 2000 Phenobarbital (PB) administration (0.1% in drinking water; 15 days) elicited an enhancement in liver microsomal functions, lipid peroxidation, and GSH content, without changes in oxidative stress-related enzymatic activities, except for the elevation in those of glutathione reductase and glutathione-S-transferase, compared to control rats. Phenobarbital 15-17 hematopoietic prostaglandin D synthase Rattus norvegicus 289-314 9279133-3 1997 NADPH dependent lipid peroxidation and cytosolic glutathione-s-transferase activity were also enhanced due to PB and 3-MC treatment but the magnitude of increase was less in FR animals. Phenobarbital 110-112 hematopoietic prostaglandin D synthase Rattus norvegicus 49-74 8824533-0 1996 Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat. Phenobarbital 68-81 hematopoietic prostaglandin D synthase Rattus norvegicus 154-179 8801059-4 1996 An elevation of GST activities by 45 to 100% was observed after pretreatment of rats with phenobarbital (PB). Phenobarbital 105-107 hematopoietic prostaglandin D synthase Rattus norvegicus 16-19 8053925-6 1994 As expected, PB and MC increased GST activity together with the concentration of subunits 1 and 3 in rats. Phenobarbital 13-15 hematopoietic prostaglandin D synthase Rattus norvegicus 33-36 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital 124-137 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital 124-137 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital 139-141 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Phenobarbital 139-141 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 8534266-8 1996 In liver cytosol from rats treated with phenobarbital (PB), curcumin inhibited GST activity in a mixed-type manner with a Ki of 5.75 microM and Ki of 12.5 microM. Phenobarbital 40-53 hematopoietic prostaglandin D synthase Rattus norvegicus 79-82 8534266-8 1996 In liver cytosol from rats treated with phenobarbital (PB), curcumin inhibited GST activity in a mixed-type manner with a Ki of 5.75 microM and Ki of 12.5 microM. Phenobarbital 55-57 hematopoietic prostaglandin D synthase Rattus norvegicus 79-82 7624894-8 1995 The mouse liver GST activity toward AFB1-epoxide was 3-fold greater than that of phenobarbital-induced rats, 4.5-fold greater than DR rats, and 14.7-fold greater than the GST activity of AL rats. Phenobarbital 81-94 hematopoietic prostaglandin D synthase Rattus norvegicus 16-19 7886683-6 1995 Phenobarbital increased GST activity in the liver but not in lung or pancreas. Phenobarbital 0-13 hematopoietic prostaglandin D synthase Rattus norvegicus 24-27 8334163-7 1993 Treatment of the hepatocyte cultures with phenobarbital (2 mM) or 3-methylcholanthene (5 microM) for 24, 48, or 72 h, beginning 24 h after plating, resulted in significant increases in glutathione S-transferase activity relative to control, with maximal increases of 158 and 164% measured at 72 h following phenobarbital or 3-methylcholanthrene treatment, respectively. Phenobarbital 42-55 hematopoietic prostaglandin D synthase Rattus norvegicus 185-210 8198522-8 1994 Administration of the antioxidants EQ, BHA or BHT, as well as PB, led to a marked increase in levels of the GST Yc2 subunit in rat liver, and this increase coincided with a substantial rise in the GST activity towards AFB1-8,9-epoxide; neither AFB1, 3-MC nor clofibrate caused induction of Yc2 or any of the GST subunits examined. Phenobarbital 62-64 hematopoietic prostaglandin D synthase Rattus norvegicus 108-111 8198522-8 1994 Administration of the antioxidants EQ, BHA or BHT, as well as PB, led to a marked increase in levels of the GST Yc2 subunit in rat liver, and this increase coincided with a substantial rise in the GST activity towards AFB1-8,9-epoxide; neither AFB1, 3-MC nor clofibrate caused induction of Yc2 or any of the GST subunits examined. Phenobarbital 62-64 hematopoietic prostaglandin D synthase Rattus norvegicus 197-200 8242872-0 1993 Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital. Phenobarbital 159-172 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 8242872-9 1993 Upon PB treatment expression of the GST subunits Yb1 and Yb2 was frequently elevated in ECF, while Ya and Yc remained more or less unchanged. Phenobarbital 5-7 hematopoietic prostaglandin D synthase Rattus norvegicus 36-39 8334163-7 1993 Treatment of the hepatocyte cultures with phenobarbital (2 mM) or 3-methylcholanthene (5 microM) for 24, 48, or 72 h, beginning 24 h after plating, resulted in significant increases in glutathione S-transferase activity relative to control, with maximal increases of 158 and 164% measured at 72 h following phenobarbital or 3-methylcholanthrene treatment, respectively. Phenobarbital 307-320 hematopoietic prostaglandin D synthase Rattus norvegicus 185-210 8440422-4 1993 Phenobarbital caused an induction of GST activity in culture at 72 and 168 hr. Phenobarbital 0-13 hematopoietic prostaglandin D synthase Rattus norvegicus 37-40 8330366-0 1993 Modulation of aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci by pretreatment of rats with phenobarbital and buthionine sulfoximine. Phenobarbital 127-140 hematopoietic prostaglandin D synthase Rattus norvegicus 35-60 2060617-0 1991 Regulation of glutathione S-transferase gene expression by phenobarbital in cultured adult rat hepatocytes. Phenobarbital 59-72 hematopoietic prostaglandin D synthase Rattus norvegicus 14-39 1553756-1 1992 Glutathione S-transferase (GST) expression was examined in hepatic cytosol from rats and rabbits treated with 4-picoline, pyrrole, pyridine, pyrazine, imidazole, or piperidine using enzymatic activity, SDS-PAGE, and immunoblot analyses and the results were compared to those obtained with phenobarbital and 3-methylcholanthrene. Phenobarbital 289-302 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 1553756-1 1992 Glutathione S-transferase (GST) expression was examined in hepatic cytosol from rats and rabbits treated with 4-picoline, pyrrole, pyridine, pyrazine, imidazole, or piperidine using enzymatic activity, SDS-PAGE, and immunoblot analyses and the results were compared to those obtained with phenobarbital and 3-methylcholanthrene. Phenobarbital 289-302 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 1859462-0 1991 Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver. Phenobarbital 46-59 hematopoietic prostaglandin D synthase Rattus norvegicus 84-109 1859462-1 1991 The effect of age, gender and phenobarbital treatment on the hepatic cytosolic glutathione S-transferase subunit composition was studied in Brown Norway rats. Phenobarbital 30-43 hematopoietic prostaglandin D synthase Rattus norvegicus 79-104 1859462-7 1991 In all the age groups studied phenobarbital administration (45 mg/kg body weight, i.p., once a day for 7 days) doubled total glutathione S-transferase protein in both genders and affected the subunit composition in a significant way, emphasizing the already existing differences between genders. Phenobarbital 30-43 hematopoietic prostaglandin D synthase Rattus norvegicus 125-150 1553756-5 1992 While phenobarbital and 3-methylcholanthrene induce class alpha and mu GST expression in rat hepatic cytosol, one of the most interesting observations was that neither of these agents stimulated GST expression in the rabbit. Phenobarbital 6-19 hematopoietic prostaglandin D synthase Rattus norvegicus 71-74 2060617-1 1991 Previous studies, by using Northern blotting analyses, showed that phenobarbital (PB) affects the steady-state mRNA levels of glutathione S-transferase (GST) subunits 1/2, 3/4 and 7 in both conventional cultures of adult rat hepatocytes and co-cultures, with rat liver epithelial cells [Vandenberghe et al., 1989, FEBS Lett. Phenobarbital 67-80 hematopoietic prostaglandin D synthase Rattus norvegicus 126-151 2060617-1 1991 Previous studies, by using Northern blotting analyses, showed that phenobarbital (PB) affects the steady-state mRNA levels of glutathione S-transferase (GST) subunits 1/2, 3/4 and 7 in both conventional cultures of adult rat hepatocytes and co-cultures, with rat liver epithelial cells [Vandenberghe et al., 1989, FEBS Lett. Phenobarbital 67-80 hematopoietic prostaglandin D synthase Rattus norvegicus 153-156 2060617-1 1991 Previous studies, by using Northern blotting analyses, showed that phenobarbital (PB) affects the steady-state mRNA levels of glutathione S-transferase (GST) subunits 1/2, 3/4 and 7 in both conventional cultures of adult rat hepatocytes and co-cultures, with rat liver epithelial cells [Vandenberghe et al., 1989, FEBS Lett. Phenobarbital 82-84 hematopoietic prostaglandin D synthase Rattus norvegicus 126-151 2060617-1 1991 Previous studies, by using Northern blotting analyses, showed that phenobarbital (PB) affects the steady-state mRNA levels of glutathione S-transferase (GST) subunits 1/2, 3/4 and 7 in both conventional cultures of adult rat hepatocytes and co-cultures, with rat liver epithelial cells [Vandenberghe et al., 1989, FEBS Lett. Phenobarbital 82-84 hematopoietic prostaglandin D synthase Rattus norvegicus 153-156 2060617-5 1991 Data from this study demonstrate that the increase in steady-state mRNA levels observed in both conventional culture and co-culture after 4 days PB exposure results from an increased transcriptional activity of the GST genes. Phenobarbital 145-147 hematopoietic prostaglandin D synthase Rattus norvegicus 215-218 2262816-9 1990 Nevertheless, it was important for the induction of both GST-A and GST-B by PB treatment. Phenobarbital 76-78 hematopoietic prostaglandin D synthase Rattus norvegicus 57-60 2011611-0 1991 Phenobarbital increases rat hepatic prostaglandin F2 alpha, glutathione S-transferase activity and oxidative stress. Phenobarbital 0-13 hematopoietic prostaglandin D synthase Rattus norvegicus 60-85 2011611-2 1991 PB treatment increased glutathione S-transferase (GST) activity by 80% and prostaglandin (PG) F2 alpha levels 4-fold (p less than 0.05). Phenobarbital 0-2 hematopoietic prostaglandin D synthase Rattus norvegicus 23-48 2011611-2 1991 PB treatment increased glutathione S-transferase (GST) activity by 80% and prostaglandin (PG) F2 alpha levels 4-fold (p less than 0.05). Phenobarbital 0-2 hematopoietic prostaglandin D synthase Rattus norvegicus 50-53 2011611-7 1991 PB"s effect on PGF2 alpha could be a result of both GST-mediated prostaglandin synthesis and oxidative stress. Phenobarbital 0-2 hematopoietic prostaglandin D synthase Rattus norvegicus 52-55 2575507-0 1989 Dose-related effects of phenobarbital on hepatic glutathione-S-transferase activity and ligandin levels in the rat. Phenobarbital 24-37 hematopoietic prostaglandin D synthase Rattus norvegicus 49-74 2306705-0 1990 Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development. Phenobarbital 118-138 hematopoietic prostaglandin D synthase Rattus norvegicus 142-167 2315263-0 1990 Inverse relationship between total glutathione S-transferase content and bile acid release in isolated hepatocytes from untreated, phenobarbital pretreated and hypothyroid rats. Phenobarbital 131-144 hematopoietic prostaglandin D synthase Rattus norvegicus 35-60 2315263-6 1990 The levels of total glutathione S-transferase content were significantly (P less than 0.001) increased in the hepatocytes from both hypothyroid and phenobarbital pretreated animals. Phenobarbital 148-161 hematopoietic prostaglandin D synthase Rattus norvegicus 20-45 2635735-0 1989 Induction of glutathione S-transferase by phenobarbital in rat hepatocyte culture. Phenobarbital 42-55 hematopoietic prostaglandin D synthase Rattus norvegicus 13-38 2635735-1 1989 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Phenobarbital 23-36 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 2635735-1 1989 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Phenobarbital 23-36 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 2635735-2 1989 Treatment of hepatocytes with a medium containing 6 or 8 mM phenobarbital for 20 h increased the specific activity of GST approx. Phenobarbital 60-73 hematopoietic prostaglandin D synthase Rattus norvegicus 118-121 2635735-4 1989 When induction of GST by phenobarbital treatment was observed, the cellular level of phenobarbital determined by HPLC was approx. Phenobarbital 25-38 hematopoietic prostaglandin D synthase Rattus norvegicus 18-21 2635735-4 1989 When induction of GST by phenobarbital treatment was observed, the cellular level of phenobarbital determined by HPLC was approx. Phenobarbital 85-98 hematopoietic prostaglandin D synthase Rattus norvegicus 18-21 2635735-6 1989 Thus, an inductive effect of phenobarbital on GST was observed in vitro as well as in rat liver. Phenobarbital 29-42 hematopoietic prostaglandin D synthase Rattus norvegicus 46-49 2612064-11 1989 These data indicate a differential induction of glutathione S-transferase isoenzymes and suggest that clotrimazole is a phenobarbital-type inducer of enzyme activity. Phenobarbital 120-133 hematopoietic prostaglandin D synthase Rattus norvegicus 48-73 2890493-6 1987 GST substrate activities in response to phenobarbital, butylated hydroxy-anisole or 5,5"-diphenylhydantoin treatment were increased more often in mouse and rat as compared to the hamster. Phenobarbital 40-53 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 2753164-0 1989 Effect of phenobarbital on the expression of glutathione S-transferase isoenzymes in cultured rat hepatocytes. Phenobarbital 10-23 hematopoietic prostaglandin D synthase Rattus norvegicus 45-70 2753164-1 1989 Cultured adult rat hepatocytes were treated daily with 3.2 mM phenobarbital (PB) in order to study its effect on the expression of cytosolic glutathione S-transferase isoenzymes. Phenobarbital 62-75 hematopoietic prostaglandin D synthase Rattus norvegicus 141-166 2753164-1 1989 Cultured adult rat hepatocytes were treated daily with 3.2 mM phenobarbital (PB) in order to study its effect on the expression of cytosolic glutathione S-transferase isoenzymes. Phenobarbital 77-79 hematopoietic prostaglandin D synthase Rattus norvegicus 141-166 2753164-2 1989 Glutathione S-transferase (GST) activities, using 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene as substrates, were increased when PB was present in the culture medium. Phenobarbital 145-147 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 2753164-2 1989 Glutathione S-transferase (GST) activities, using 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene as substrates, were increased when PB was present in the culture medium. Phenobarbital 145-147 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 2753164-3 1989 After purification and separation of GST on glutathione Sepharose 6 B and reversed-phase HPLC, respectively, it was observed in vitro that PB caused an increase in the relative amounts of subunits 1, 3 and 7 compared to subunits 2 and 4. Phenobarbital 139-141 hematopoietic prostaglandin D synthase Rattus norvegicus 37-40 3338104-1 1988 The effects of 2-acetylaminofluorene (2-AAF), phenobarbital (PB) and butylated hydroxyanisole (BHA) on the competitive proliferation of glutathione S-transferase (GST-P) positive liver cell foci induced by diethylnitrosamine (DEN) and surrounding hepatocytes were studied. Phenobarbital 46-59 hematopoietic prostaglandin D synthase Rattus norvegicus 136-161 3338104-1 1988 The effects of 2-acetylaminofluorene (2-AAF), phenobarbital (PB) and butylated hydroxyanisole (BHA) on the competitive proliferation of glutathione S-transferase (GST-P) positive liver cell foci induced by diethylnitrosamine (DEN) and surrounding hepatocytes were studied. Phenobarbital 61-63 hematopoietic prostaglandin D synthase Rattus norvegicus 136-161 3358961-0 1988 [Isolation and comparative analysis of multiple isoenzymes of glutathione-S-transferase from the liver of intact rats and rats administered phenobarbital, 3-methylcholanthrene and butylhydroxytoluene]. Phenobarbital 140-153 hematopoietic prostaglandin D synthase Rattus norvegicus 62-87 3358961-6 1988 A conclusion was drawn that BHT and PB induced the GST subunits 1 and 3, whereas MC--subunits 2 and 4. Phenobarbital 36-38 hematopoietic prostaglandin D synthase Rattus norvegicus 51-54 3105185-0 1987 Difference in the effects of phenobarbital and 3-methylcholanthrene treatment on subunit composition of hepatic glutathione S-transferase in male and female rats. Phenobarbital 29-42 hematopoietic prostaglandin D synthase Rattus norvegicus 112-137 3557278-0 1986 Phenobarbital treatment increased the astroglia-specific enzyme, glutathione S-transferase in rat brain. Phenobarbital 0-13 hematopoietic prostaglandin D synthase Rattus norvegicus 65-90 3489949-5 1986 PB induced soluble glutathione S-transferase, a detoxifying enzyme, only in rats fed dietary fats. Phenobarbital 0-2 hematopoietic prostaglandin D synthase Rattus norvegicus 19-44 4020114-5 1985 PB effects were manifested by the persistent decrease in rats" body weight, increase in the liver weight, increase in the cytoplasmatic activity of glutathione S-transferase in the liver and increase in TDGA urinary excretion. Phenobarbital 0-2 hematopoietic prostaglandin D synthase Rattus norvegicus 148-173 2411220-0 1985 Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene. Phenobarbital 75-88 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 3920836-5 1985 PB, PCB and MC treatments enhanced the activity of enzymes involved in conjugation reactions, UDP-glucuronyltransferase and glutathione S-transferase, whereas the dietary manipulation and ethanol consumption produced no significant effect on these enzymes. Phenobarbital 0-2 hematopoietic prostaglandin D synthase Rattus norvegicus 124-149 6201621-5 1984 In addition, PB protected cultures from the cytotoxic effects of AFB1, as evidenced by a significantly reduced (p less than 0.05) leakage of lactate dehydrogenase into the medium at 51 h. Elevated mixed-function oxidase and glutathione S-transferase activities, as well as higher levels of AFB1-glutathione conjugate were measured in cultures from rats pretreated with PB. Phenobarbital 13-15 hematopoietic prostaglandin D synthase Rattus norvegicus 224-249 6273441-7 1982 Phenobarbital treatment resulted in a 3.2-fold increase in glutathione S-transferase mRNA over levels found in control rats, while trans-stilbene oxide increased glutathione S-transferase mRNA levels 5.7-fold. Phenobarbital 0-13 hematopoietic prostaglandin D synthase Rattus norvegicus 59-84 6791701-1 1981 Following administration of phenobarbital to rats, liver ligandin content, bilirubin binding, glutathione-S-transferase and steroid isomerase activities increased by 150% and the 22000-dalton subunit was selectively increased. Phenobarbital 28-41 hematopoietic prostaglandin D synthase Rattus norvegicus 94-119 6325423-1 1984 Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital. Phenobarbital 140-153 hematopoietic prostaglandin D synthase Rattus norvegicus 34-59 7083399-0 1982 Effects of phenobarbital and sodium salicylate on cytochrome P-450 mixed function oxygenase and glutathione S-transferase activities in rat brain. Phenobarbital 11-24 hematopoietic prostaglandin D synthase Rattus norvegicus 96-121 7083399-1 1982 The effects of acute and therapeutic doses of phenobarbital and sodium salicylate on cytochrome P-450 mixed function oxygenase (EC 1.14.14.1) and glutathione S-transferase (EC 2.5.1.18) activities have been studied in rat brain and compared with those of rat liver. Phenobarbital 46-59 hematopoietic prostaglandin D synthase Rattus norvegicus 146-171 7083399-10 1982 The increase in brain glutathione S-transferase by prolonged treatment of phenobarbital was significant compared to the control values. Phenobarbital 74-87 hematopoietic prostaglandin D synthase Rattus norvegicus 22-47 7213485-1 1980 In the livers of rats treated with phenobarbital an increase of glutathione-S-transferase and glutathione is observed. Phenobarbital 35-48 hematopoietic prostaglandin D synthase Rattus norvegicus 64-89 697926-0 1978 Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat. Phenobarbital 18-31 hematopoietic prostaglandin D synthase Rattus norvegicus 114-139