PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32934200-0 2020 TET2 directs mammary luminal cell differentiation and endocrine response. Phenobarbital 21-28 tet methylcytosine dioxygenase 2 Mus musculus 0-4 32934200-3 2020 Here, using our recently established mammary specific Tet2 deletion mouse model, the data reveals that TET2 plays a pivotal role in mammary gland development and luminal lineage commitment. Phenobarbital 162-169 tet methylcytosine dioxygenase 2 Mus musculus 54-58 32934200-3 2020 Here, using our recently established mammary specific Tet2 deletion mouse model, the data reveals that TET2 plays a pivotal role in mammary gland development and luminal lineage commitment. Phenobarbital 162-169 tet methylcytosine dioxygenase 2 Mus musculus 103-107 32934200-4 2020 We show that TET2 and FOXP1 form a chromatin complex that mediates demethylation of ESR1, GATA3, and FOXA1, three key genes that are known to coordinately orchestrate mammary luminal lineage specification and endocrine response, and also are often silenced by DNA methylation in aggressive breast cancers. Phenobarbital 175-182 tet methylcytosine dioxygenase 2 Mus musculus 13-17 32934200-6 2020 As a result, this study elucidates a role for TET2 in governing luminal cell differentiation and endocrine response that underlies breast cancer resistance to anti-estrogen treatments. Phenobarbital 64-71 tet methylcytosine dioxygenase 2 Mus musculus 46-50