PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34725332-5 2021 Furthermore, we found a set of hormone-responsive lineage-specific transcription factors, FOXA1, GATA3, ERalpha, directly drove high expression of ARSD through chromatin looping in luminal subtype BC cells. Phenobarbital 181-188 forkhead box A1 Homo sapiens 90-95 34517157-6 2021 Combined expression of FOXA1 and GATA3 was statistically higher in luminal subtypes in comparison to non-luminal subtypes. Phenobarbital 67-74 forkhead box A1 Homo sapiens 23-28 34517157-8 2021 FOXA1 and GATA3 were significantly upregulated in luminal B subtype, where EGFR and PTGS2 were significantly downregulated. Phenobarbital 50-57 forkhead box A1 Homo sapiens 0-5 34517157-12 2021 Combined expression of ESR1, FOXA1 and GATA3 represents a molecular signature of luminal subtypes. Phenobarbital 81-88 forkhead box A1 Homo sapiens 29-34 32374509-12 2020 Increased expression of the luminal markers FOXA1 and SCUBE2, were found to be significantly associated with better DFS. Phenobarbital 28-35 forkhead box A1 Homo sapiens 44-49 34101624-7 2021 FOXA1 overexpression could be a prognostic factor to predict therapy resistance and a viable target to sensitize luminal prostate, breast and bladder cancer to immuno- and chemotherapy. Phenobarbital 113-120 forkhead box A1 Homo sapiens 0-5 34249460-2 2021 We postulate that pregnancy-associated repression of FOXA1 results in the accumulation of aberrant, differentiation-arrested luminal progenitor cells which, following additional genetic and epigenetic insults, may give rise to ER- tumors. Phenobarbital 125-132 forkhead box A1 Homo sapiens 53-58 33858483-2 2021 Transcriptionally, FOXA1, GATA3, and PPARG are shown to be essential for luminal subtype-specific gene regulation and subtype switching, while TP63, STAT3, and TFAP2 family members are critical for regulation of basal subtype-specific genes. Phenobarbital 73-80 forkhead box A1 Homo sapiens 19-24 33858483-4 2021 RESULT: We determine the genome-wide transcriptome, enhancer landscape, and transcription factor binding profiles of FOXA1 and GATA3 in luminal and basal subtypes of bladder cancer. Phenobarbital 136-143 forkhead box A1 Homo sapiens 117-122 33417085-5 2021 FOXA1, together with EP300 and RUNX1, regulates the expression of E-cadherin, and is expressed in luminal, but absent in triple-negative and basal-like breast cancers. Phenobarbital 98-105 forkhead box A1 Homo sapiens 0-5 33417085-8 2021 RESULTS: Upon FOXA1 knockdown in luminal MCF-7 and T47D cells, we found an increase in doxorubicin and paclitaxel sensitivity as well as a decrease in anchorage independence. Phenobarbital 33-40 forkhead box A1 Homo sapiens 14-19 33118597-6 2021 RESULTS: The phenotype of NVUC was classified as luminal from 60.1% (FOXA1+/CK5/6-) to 100% (GATA3+/CK14-) of cases using composite phenotypes. Phenobarbital 49-56 forkhead box A1 Homo sapiens 69-74 32816853-4 2020 In normal breast tissue, parity has been associated with hypermethylation of FOXA1, a pioneer transcription factor which promotes the luminal phenotype in luminal progenitors, while repressing the basal phenotype. Phenobarbital 134-141 forkhead box A1 Homo sapiens 77-82 32816853-4 2020 In normal breast tissue, parity has been associated with hypermethylation of FOXA1, a pioneer transcription factor which promotes the luminal phenotype in luminal progenitors, while repressing the basal phenotype. Phenobarbital 155-162 forkhead box A1 Homo sapiens 77-82 34706362-3 2021 In this study, we aimed to correlate FOXA1, a marker for differentiation of the basal and luminal subtypes, with tumor immune cell infiltration and the effect of chemotherapy in bladder cancer. Phenobarbital 90-97 forkhead box A1 Homo sapiens 37-42 35021081-5 2022 2HG induces loss of motif accessibility to the luminal-defining transcriptional factors FOXA1, FOXP1, and GATA3 and a shift from luminal to basal-like gene expression. Phenobarbital 47-54 forkhead box A1 Homo sapiens 88-93 31519689-8 2019 Targeting MUC1-C and these NuRD components also induced expression of FOXA1, GATA3, and other markers associated with the luminal phenotype. Phenobarbital 122-129 forkhead box A1 Homo sapiens 70-75 31871111-1 2020 BACKGROUND: Forkhead box protein A1 (FOXA1) promotes luminal differentiation, and hypermethylation of the gene can be a mechanism of developing estrogen receptor-negative (ER-) breast cancer. Phenobarbital 53-60 forkhead box A1 Homo sapiens 12-35 31871111-1 2020 BACKGROUND: Forkhead box protein A1 (FOXA1) promotes luminal differentiation, and hypermethylation of the gene can be a mechanism of developing estrogen receptor-negative (ER-) breast cancer. Phenobarbital 53-60 forkhead box A1 Homo sapiens 37-42 31888566-10 2019 CONCLUSIONS: We identified an AR+ FOXA1+ CK14- subgroup of triple-negative FMCs that might correspond to the luminal-AR subgroup of human triple-negative breast cancers. Phenobarbital 109-116 forkhead box A1 Homo sapiens 34-39 32822399-4 2020 The luminal subtype is less aggressive and is predominately characterized by elevated gene expression of peroxisome proliferator-activated receptor- gamma (PPARgamma) and forkhead box protein A1 (FOXA1). Phenobarbital 4-11 forkhead box A1 Homo sapiens 171-194 32822399-4 2020 The luminal subtype is less aggressive and is predominately characterized by elevated gene expression of peroxisome proliferator-activated receptor- gamma (PPARgamma) and forkhead box protein A1 (FOXA1). Phenobarbital 4-11 forkhead box A1 Homo sapiens 196-201