PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8208127-3	1994	Using the standard induction procedures [Aroclor 1254 or a combination of phenobarbitone (PB) and beta-naphthoflavone (beta-NF)] the level of CYP2E1 in rat liver is actually suppressed and it has been suggested that this may account for the negative findings with these compounds in the Ames test.	Phenobarbital	74-88	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	142-148	
10598746-11	1999	Microsomes from phenobarbitone and isoniazid-pretreated animals significantly (p < 0.05) enhanced the formation of AQ4 from AQ4N indicating a role for CYP2B and 2E respectively.	Phenobarbital	16-30	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	154-166	
10215695-3	1999	In the present study, we examined the effects of insulin on pyridine-, phenobarbital-, and ciprofibrate-mediated expression of CYP2E1, CYP2B, CYP3A, and CYP4A in primary cultured rat hepatocytes.	Phenobarbital	71-84	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	127-133	
8195225-5	1994	Increase in the ionic strength also enhanced the rate of cytochrome P450 reduction in control and phenobarbital-induced rat liver microsomes and in reconstituted systems containing purified rat liver CYP2C6, CYP2C12, CYP2C13, and CYP2E1, and rat reductase.	Phenobarbital	98-111	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	230-236	
15946133-8	2005	CYP1A1/2, CYP2B1, CYP3A2, CYP4A1, and CYP2E1 were induced by the addition of 3-methylcholanthrene, phenobarbital, pregnenolone-16alpha-carbonitrile, clofibric acid, and ethanol, respectively.	Phenobarbital	99-112	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	38-44	
16421897-8	2005	Notably, phenobarbital resulted in significant induction of CYP2B1, CYP2B2, CYP2C6, CYP2C13, CYP2E1, CYP3A1, and CYP3A2.	Phenobarbital	9-22	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	93-99	
9571220-12	1998	Oral administration of phenobarbital or acetone increased CYP2B and CYP2E1 activities in rat liver but had no significant effect on P450 activities in subcompartments of rat lung.	Phenobarbital	23-36	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	68-74	
8948088-7	1996	Despite an apparent down-regulation of CYP2E1 expression occurring in all rats as a result of PB induction, P females maintained higher 2E1 levels and showed enhanced MEOS, 4-AOH and PNP-OH activities with respect to NP females.	Phenobarbital	94-96	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	39-45	
8627517-7	1996	Pyridine or phenobarbital potentiation of CCl4-induced increases in ALT activity implys that cytochrome P450 2E1 (P450 2E1) and P450 2B expression may be associated with the increased toxicity.	Phenobarbital	12-25	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	93-112	
8825185-16	1996	Enhanced CYP2E1 or CYP2B1/2B2 levels after treatment with pyridine or phenobarbital elevated c-fos mRNA over untreated controls.	Phenobarbital	70-83	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	9-15	
8560502-8	1995	Induction of CYP2E1 and CYP2B1/2 with pyridine and phenobarbital, respectively, did not alter this lack of effect.	Phenobarbital	51-64	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19	
8208127-3	1994	Using the standard induction procedures [Aroclor 1254 or a combination of phenobarbitone (PB) and beta-naphthoflavone (beta-NF)] the level of CYP2E1 in rat liver is actually suppressed and it has been suggested that this may account for the negative findings with these compounds in the Ames test.	Phenobarbital	90-92	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	142-148	
2766463-6	1989	These results indicate that (i) cytochromes P-450b,e and P-450j contribute to benzene metabolism in rat liver; (ii) the former has a low affinity to benzene and is induced by PB; and (iii) P-450j has a high affinity to benzene and is induced by 1-day fasting, pyrazole and ethanol, but decreased by PB treatment.	Phenobarbital	175-177	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	57-63	
34806938-3	2021	In vivo study, Sprague-Dawley male rats were treated with MTBH (25, 50 or 100 mg/kg for 28 consecutive days), phenobarbital (80 mg/kg for 12 consecutive days) or 0.5% CMC-Na solution (control group) by intragastric administration, then, the mRNA, protein levels and activities of liver P450s were analyzed by real-time PCR, western blotting and probe-drug incubation systems, respectively.The in vitro study indicated that MTBH inhibits the activities of CYP3A1/4 and CYP2E1 in rat and human liver microsomes.	Phenobarbital	110-123	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	468-474	
2519734-9	1989	The inhibition patterns observed when an antibody inhibitory to cytochrome P-450j was added to microsomes derived from control and ethanol- and phenobarbital-pretreated rats conclusively demonstrate that NDMA and NDEA are preferentially metabolized by distinct isozymes of cytochrome P-450.	Phenobarbital	144-157	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	64-81	
2766463-6	1989	These results indicate that (i) cytochromes P-450b,e and P-450j contribute to benzene metabolism in rat liver; (ii) the former has a low affinity to benzene and is induced by PB; and (iii) P-450j has a high affinity to benzene and is induced by 1-day fasting, pyrazole and ethanol, but decreased by PB treatment.	Phenobarbital	175-177	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195	
2766463-6	1989	These results indicate that (i) cytochromes P-450b,e and P-450j contribute to benzene metabolism in rat liver; (ii) the former has a low affinity to benzene and is induced by PB; and (iii) P-450j has a high affinity to benzene and is induced by 1-day fasting, pyrazole and ethanol, but decreased by PB treatment.	Phenobarbital	299-301	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	57-63	
2766463-6	1989	These results indicate that (i) cytochromes P-450b,e and P-450j contribute to benzene metabolism in rat liver; (ii) the former has a low affinity to benzene and is induced by PB; and (iii) P-450j has a high affinity to benzene and is induced by 1-day fasting, pyrazole and ethanol, but decreased by PB treatment.	Phenobarbital	299-301	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195	
18798224-10	2009	The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats.	Phenobarbital	4-6	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	39-45	
3418515-4	1988	Immunochemical analysis confirmed that the level of immunoreactive P-450j protein was increased in PY-induced microsomes as compared to preparations from control, phenobarbital- or beta-naphthoflavone-induced animals.	Phenobarbital	163-176	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	67-73	
3782137-7	1986	Amino acid alignment also revealed that P450j was 48% similar to P450b and P450e, the major phenobarbital-inducible forms, and 54% similar to P450PB1 and P450f, two developmentally regulated forms.	Phenobarbital	92-105	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	40-45	
17011741-3	2007	This study utilized precision-cut rat liver slices in dynamic organ culture to assess the effects of various media on the viability of rat liver slices and the expression of CYP2B and CYP2E1 when the slices are exposed to phenobarbital and isoniazid, which are drugs capable of inducing these respective CYPs.	Phenobarbital	222-235	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	184-190	
16815962-5	2006	In contrast, baseline and PB-treated expressions of CYP2E1 mRNA were reduced in HF-fed rats.	Phenobarbital	26-28	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	52-58