PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32830517-3 2021 OBJECTIVE: To describe the use of fixed-dose phenobarbital monotherapy for the management of patients at risk for AWS in the surgical-trauma intensive care unit. Phenobarbital 45-58 jagged canonical Notch ligand 1 Homo sapiens 114-117 32830517-4 2021 METHODS: Surgical-trauma critically ill patients who received phenobarbital monotherapy, loading dose followed by a taper regimen, for the management of AWS were included in this evaluation. Phenobarbital 62-75 jagged canonical Notch ligand 1 Homo sapiens 153-156 32830517-5 2021 The effectiveness of phenobarbital monotherapy to treat AWS and prevent development of AWS-related complications were evaluated. Phenobarbital 21-34 jagged canonical Notch ligand 1 Homo sapiens 56-59 32830517-7 2021 RESULTS: A total of 31 patients received phenobarbital monotherapy; the majority of patients were at moderate risk for developing AWS (n = 20; 65%) versus high risk (n = 11; 35%). Phenobarbital 41-54 jagged canonical Notch ligand 1 Homo sapiens 130-133 32830517-12 2021 CONCLUSION AND RELEVANCE: Fixed-dose phenobarbital monotherapy appears to be well tolerated and effective in the management of AWS. Phenobarbital 37-50 jagged canonical Notch ligand 1 Homo sapiens 127-130 32830517-13 2021 Further evaluation is needed to determine the extent of benefit with the use of phenobarbital monotherapy for management of AWS. Phenobarbital 80-93 jagged canonical Notch ligand 1 Homo sapiens 124-127