PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22815988-5 2012 The time-course change in the phenobarbital-mediated down-regulation of miR-122 was inversely correlated with AMPK activation. Phenobarbital 30-43 microRNA 122 Homo sapiens 72-79 22815988-6 2012 Phenobarbital decreased primary miR-122 to approximately 25% of the basal level as early as 1 h and suppressed transactivity of mir-122 promoter in HuH-7 cells, suggesting that the down-regulation occurred at the transcriptional level. Phenobarbital 0-13 microRNA 122 Homo sapiens 32-39 22815988-6 2012 Phenobarbital decreased primary miR-122 to approximately 25% of the basal level as early as 1 h and suppressed transactivity of mir-122 promoter in HuH-7 cells, suggesting that the down-regulation occurred at the transcriptional level. Phenobarbital 0-13 microRNA 122 Homo sapiens 128-135 22815988-8 2012 An inhibitory RNA specific for miR-122 increased activated AMPK and CAR-mediated trancactivation of the phenobarbital-responsive enhancer module in HepG2 cells. Phenobarbital 104-117 microRNA 122 Homo sapiens 31-38 22815988-12 2012 Taken together, these results suggest that phenobarbital-mediated down-regulation of miR-122 is an early and important event in the AMPK-dependent CAR activation and transactivation of its target genes. Phenobarbital 43-56 microRNA 122 Homo sapiens 85-92