PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28058446-7 2017 Changes in the expression of classic CAR/PXR target genes such as Cyp2b10 were induced by cyproconazole and phenobarbital in both genotypes, while prochloraz treatment resulted in gene expression changes indicative of additional aryl hydrocarbon receptor activation, e.g. by up-regulation of Cyp1a1 expression. Phenobarbital 108-121 nuclear receptor subfamily 1, group I, member 2 Mus musculus 41-44 32735318-4 2020 Treatment of humanized CAR and pregnane X receptor (PXR) mice (hCAR/hPXR mice) with 1000 ppm PB for 7 days significantly increased hepatocyte RDS together with increases in several mitogenic genes. Phenobarbital 93-95 nuclear receptor subfamily 1, group I, member 2 Mus musculus 31-50 32735318-4 2020 Treatment of humanized CAR and pregnane X receptor (PXR) mice (hCAR/hPXR mice) with 1000 ppm PB for 7 days significantly increased hepatocyte RDS together with increases in several mitogenic genes. Phenobarbital 93-95 nuclear receptor subfamily 1, group I, member 2 Mus musculus 52-55 31436536-0 2019 Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. Phenobarbital 24-37 nuclear receptor subfamily 1, group I, member 2 Mus musculus 81-100 31436536-6 2019 Mammalian two-hybrid assays demonstrated that PB selectively increases the functional interaction between the steroid receptor coactivator-1 and hPXR but not mouse PXR. Phenobarbital 46-48 nuclear receptor subfamily 1, group I, member 2 Mus musculus 146-149 24690595-1 2014 The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Phenobarbital 188-201 nuclear receptor subfamily 1, group I, member 2 Mus musculus 51-70 28218408-7 2017 Cyp3a11 and Cyp2b10 were also induced in PXR-/- mice with toxaphene and phenobarbital but were not changed in treated PXR-/- /CAR-/- mice. Phenobarbital 72-85 nuclear receptor subfamily 1, group I, member 2 Mus musculus 41-44 28218408-10 2017 Liver EROD activity was also induced by both phenobarbital and toxaphene in the PXR-/- mice but not in the PXR-/- /CAR-/- mice. Phenobarbital 45-58 nuclear receptor subfamily 1, group I, member 2 Mus musculus 80-83 26215100-9 2015 AhR was suppressed by phenobarbital and 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) in a constitutive activated receptor (CAR)-dependent manner and pregnenolone-16alpha-carbonitrile in a pregnane X receptor (PXR)-dependent manner. Phenobarbital 22-35 nuclear receptor subfamily 1, group I, member 2 Mus musculus 197-216 26215100-9 2015 AhR was suppressed by phenobarbital and 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) in a constitutive activated receptor (CAR)-dependent manner and pregnenolone-16alpha-carbonitrile in a pregnane X receptor (PXR)-dependent manner. Phenobarbital 22-35 nuclear receptor subfamily 1, group I, member 2 Mus musculus 218-221 24863967-0 2014 Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Phenobarbital 0-13 nuclear receptor subfamily 1, group I, member 2 Mus musculus 81-84 24863967-1 2014 The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds. Phenobarbital 131-144 nuclear receptor subfamily 1, group I, member 2 Mus musculus 74-77 24863967-1 2014 The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds. Phenobarbital 131-144 nuclear receptor subfamily 1, group I, member 2 Mus musculus 79-98 24863967-1 2014 The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds. Phenobarbital 146-148 nuclear receptor subfamily 1, group I, member 2 Mus musculus 74-77 24863967-1 2014 The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds. Phenobarbital 146-148 nuclear receptor subfamily 1, group I, member 2 Mus musculus 79-98 27664318-10 2016 MIBK induced hepatic effects are consistent with a phenobarbital-like MOA where the initiating events are activation of the CAR and PXR nuclear receptors and resultant hepatocellular proliferation leading to rodent liver tumors. Phenobarbital 51-64 nuclear receptor subfamily 1, group I, member 2 Mus musculus 132-135 24690595-1 2014 The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Phenobarbital 188-201 nuclear receptor subfamily 1, group I, member 2 Mus musculus 72-75 24690595-1 2014 The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Phenobarbital 203-205 nuclear receptor subfamily 1, group I, member 2 Mus musculus 51-70 24690595-1 2014 The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Phenobarbital 203-205 nuclear receptor subfamily 1, group I, member 2 Mus musculus 72-75 24690595-4 2014 Wild-type and CAR(h)-PXR(h) mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Phenobarbital 133-135 nuclear receptor subfamily 1, group I, member 2 Mus musculus 14-27 24690595-6 2014 All these transcriptional responses were absent in CAR(KO)-PXR(KO) mouse livers and largely reversible in wild-type and CAR(h)-PXR(h) mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Phenobarbital 168-170 nuclear receptor subfamily 1, group I, member 2 Mus musculus 120-133 24690595-7 2014 Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CAR(h)-PXR(h) mice. Phenobarbital 13-15 nuclear receptor subfamily 1, group I, member 2 Mus musculus 232-245 20403969-11 2010 Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. Phenobarbital 141-143 nuclear receptor subfamily 1, group I, member 2 Mus musculus 25-28 20371638-3 2010 The nuclear xenobiotic receptors constitutive active/androstane receptor (CAR) and pregnane X receptor (PXR) regulate these drug inductions: CYP2C55 mRNA was increased 25-fold in PB-treated Car(+/+) but not in Car(-/-) mice and was induced in Pxr(+/+) but not Pxr(-/-) mice after PCN treatment. Phenobarbital 179-181 nuclear receptor subfamily 1, group I, member 2 Mus musculus 83-102 20371638-3 2010 The nuclear xenobiotic receptors constitutive active/androstane receptor (CAR) and pregnane X receptor (PXR) regulate these drug inductions: CYP2C55 mRNA was increased 25-fold in PB-treated Car(+/+) but not in Car(-/-) mice and was induced in Pxr(+/+) but not Pxr(-/-) mice after PCN treatment. Phenobarbital 179-181 nuclear receptor subfamily 1, group I, member 2 Mus musculus 104-107 20371638-3 2010 The nuclear xenobiotic receptors constitutive active/androstane receptor (CAR) and pregnane X receptor (PXR) regulate these drug inductions: CYP2C55 mRNA was increased 25-fold in PB-treated Car(+/+) but not in Car(-/-) mice and was induced in Pxr(+/+) but not Pxr(-/-) mice after PCN treatment. Phenobarbital 179-181 nuclear receptor subfamily 1, group I, member 2 Mus musculus 243-246 20371638-3 2010 The nuclear xenobiotic receptors constitutive active/androstane receptor (CAR) and pregnane X receptor (PXR) regulate these drug inductions: CYP2C55 mRNA was increased 25-fold in PB-treated Car(+/+) but not in Car(-/-) mice and was induced in Pxr(+/+) but not Pxr(-/-) mice after PCN treatment. Phenobarbital 179-181 nuclear receptor subfamily 1, group I, member 2 Mus musculus 260-263 19708687-1 2009 The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital on gene transcription. Phenobarbital 114-127 nuclear receptor subfamily 1, group I, member 2 Mus musculus 65-68 19708687-1 2009 The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital on gene transcription. Phenobarbital 114-127 nuclear receptor subfamily 1, group I, member 2 Mus musculus 70-89 19708687-5 2009 Interestingly, in primary cultures of hepatocytes isolated from CAR/PXR(-/-) knockout mice, phenobarbital increased HNF-4alpha levels. Phenobarbital 92-105 nuclear receptor subfamily 1, group I, member 2 Mus musculus 68-71 19708687-6 2009 In further experiments in these hepatocyte cultures we provide evidence that phenobarbital directly induces transcription of the PPARalpha gene via its HNF-4alpha response element, and indirectly by lack of inhibitory crosstalk of AMPK, CAR and PXR with HNF-4alpha. Phenobarbital 77-90 nuclear receptor subfamily 1, group I, member 2 Mus musculus 245-248 19708687-7 2009 Our results provide further insight into CAR and PXR-independent effects of phenobarbital and the crosstalk between different nuclear receptor signaling pathways. Phenobarbital 76-89 nuclear receptor subfamily 1, group I, member 2 Mus musculus 49-52 11114890-4 2000 Unexpectedly, we found that SXR can regulate CYP2B, both in cultured cells and in transgenic mice via adaptive recognition of the phenobarbital response element (PBRE). Phenobarbital 130-143 nuclear receptor subfamily 1, group I, member 2 Mus musculus 28-31 17020958-8 2007 When PXR knockout mice were challenged with the CAR activator phenobarbital, a significant up-regulation of male CYP3A44 levels was observed, whereas levels in females remained unchanged. Phenobarbital 62-75 nuclear receptor subfamily 1, group I, member 2 Mus musculus 5-8 16799975-2 2006 The constitutive androstane receptor (CAR; NR1I3) and to a lesser extent the pregnane X receptor (PXR; NR1I2) are responsible for mediating induction of many phenobarbital-responsive genes. Phenobarbital 158-171 nuclear receptor subfamily 1, group I, member 2 Mus musculus 77-96 16799975-2 2006 The constitutive androstane receptor (CAR; NR1I3) and to a lesser extent the pregnane X receptor (PXR; NR1I2) are responsible for mediating induction of many phenobarbital-responsive genes. Phenobarbital 158-171 nuclear receptor subfamily 1, group I, member 2 Mus musculus 98-101 16799975-2 2006 The constitutive androstane receptor (CAR; NR1I3) and to a lesser extent the pregnane X receptor (PXR; NR1I2) are responsible for mediating induction of many phenobarbital-responsive genes. Phenobarbital 158-171 nuclear receptor subfamily 1, group I, member 2 Mus musculus 103-108 16799975-6 2006 In addition, nuclear expression of HNF-4alpha protein is significantly elevated 3 hours after the administration of phenobarbital in wild-type, CAR-/-, and CAR-/-/PXR-/- mice. Phenobarbital 116-129 nuclear receptor subfamily 1, group I, member 2 Mus musculus 163-166 18677425-7 2008 To demonstrate the utility of this panel of mice, we used the mice to show that the in vivo induction of Cyp3a11 and Cyp2b10 by phenobarbital was only mediated by CAR, although this compound is described as a PXR and CAR activator in vitro. Phenobarbital 128-141 nuclear receptor subfamily 1, group I, member 2 Mus musculus 209-212 12695338-6 2003 Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice. Phenobarbital 14-27 nuclear receptor subfamily 1, group I, member 2 Mus musculus 109-115 12695338-6 2003 Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice. Phenobarbital 29-31 nuclear receptor subfamily 1, group I, member 2 Mus musculus 109-115 12695338-6 2003 Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice. Phenobarbital 150-152 nuclear receptor subfamily 1, group I, member 2 Mus musculus 109-115 12695338-7 2003 We also examined the effect of PXR ablation on PB-inducible hepatic CYP3A activity in vivo. Phenobarbital 47-49 nuclear receptor subfamily 1, group I, member 2 Mus musculus 31-34 12695338-8 2003 Microsomes isolated from PB-treated PXR-KO mice exhibited a significantly elevated rate of testosterone 6 beta-hydroxylation when compared with microsomes isolated from wild-type PB-treated mice. Phenobarbital 25-27 nuclear receptor subfamily 1, group I, member 2 Mus musculus 36-42 12695338-9 2003 PB treatment produced significantly increased levels of hepatomegaly in PXR-KO mice when compared with wild-type PB-treated mice. Phenobarbital 0-2 nuclear receptor subfamily 1, group I, member 2 Mus musculus 72-78