PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34911496-3 2021 Cancer de-differentiation transforms luminal-like (differentiated) adenocarcinoma into less luminal-like and more stem-like (undifferentiated) small cell carcinoma through a sequential activation of stem cell transcription factors (scTF) POU5F1, LIN28A, SOX2 and NANOG. Phenobarbital 37-44 SRY-box transcription factor 2 Homo sapiens 254-258 29417440-5 2018 Phenobarbital also reduced expression of neuronal markers (doublecortin (DCX), calretinin, NeuN), neuronal transcription factors (Pax6, Sox2, Tbr1/2, Prox1), and neurotrophins (NGF, BDNF, NT-3) up to 24 h after the last administration. Phenobarbital 0-13 SRY-box transcription factor 2 Homo sapiens 136-140 32191225-5 2020 Using high-throughput transcriptional data available from the METABRIC dataset, high expression of SOX2 was significantly more common in luminal-B and HER2-enriched subtypes according to PAM50 classifier and in IntClust1 (high proliferating luminal-B) and IntClust 5 (luminal-B and HER2-amplified) according to integrative clustering. Phenobarbital 137-144 SRY-box transcription factor 2 Homo sapiens 99-103 32191225-5 2020 Using high-throughput transcriptional data available from the METABRIC dataset, high expression of SOX2 was significantly more common in luminal-B and HER2-enriched subtypes according to PAM50 classifier and in IntClust1 (high proliferating luminal-B) and IntClust 5 (luminal-B and HER2-amplified) according to integrative clustering. Phenobarbital 241-248 SRY-box transcription factor 2 Homo sapiens 99-103 32191225-7 2020 Iadademstat reduced the expression of SOX2 in luminal-B but not in luminal-A mammospheres, likely indicating a selective targeting of SOX2-driven CSC. Phenobarbital 46-53 SRY-box transcription factor 2 Homo sapiens 38-42