PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12076846-5 2002 Pre-treatment with PB (80 mg/kg; once daily for 4 days) significantly increased CYP(450) content and activity in mouse liver. Phenobarbital 19-21 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 80-88 9007046-16 1997 These data indicate that MX is a PB-like inducer of cytochrome P-450 enzymes and may cause liver tumors in a manner analogous to PB. Phenobarbital 33-35 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 52-68 9685045-9 1998 Significant increases in immunodetectable levels of CYP 2B were, however, detected in toxaphene-treated mice, and are consistent with earlier reports demonstrating that toxaphene, like many other pesticides, induces the phenobarbital-inducible subfamily of CYP. Phenobarbital 220-233 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 52-55 9685045-9 1998 Significant increases in immunodetectable levels of CYP 2B were, however, detected in toxaphene-treated mice, and are consistent with earlier reports demonstrating that toxaphene, like many other pesticides, induces the phenobarbital-inducible subfamily of CYP. Phenobarbital 220-233 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 257-260 9357489-2 1997 Phenobarbitone (inducer) treatment showed induced levels of hepatic mitochondrial and microsomal cytochrome P-450 and glutathione-S-transferase in normal as well as in infected mice. Phenobarbital 0-14 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 97-143 8713075-2 1996 We analysed the basal expression and the phenobarbital inducibility of both cytochrome P-450 mRNAs by semi-quantitative specific reverse transcription-PCR analyses in five inbred mouse strains (A/J,BALB/cByJ,C57BL/6J, DBA/2J and SWR/J). Phenobarbital 41-54 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 76-92 8795461-1 1996 Rapid-onset cataracts were induced in SPF C57 bl/6 mice by intraperitoneal administration of naphthalene following cytochrome P-450 isozyme induction with phenobarbital. Phenobarbital 155-168 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 115-131 2212619-0 1990 Microphotometric analysis of cytochrome P-450 in periportal, midzonal, and perivenular hepatocytes of mice treated with phenobarbital. Phenobarbital 120-133 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 29-45 8646785-2 1996 Pretreating mice with three inducers of cytochrome P-450 (phenobarbital, clophen A50 and butylated hydroxytoluene (BHT)) increased the yield of the nitrosyl complex which correlated with a rise in the cytochrome P-450 content of mouse liver microsomes. Phenobarbital 58-71 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 40-56 8646785-2 1996 Pretreating mice with three inducers of cytochrome P-450 (phenobarbital, clophen A50 and butylated hydroxytoluene (BHT)) increased the yield of the nitrosyl complex which correlated with a rise in the cytochrome P-450 content of mouse liver microsomes. Phenobarbital 58-71 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 201-217 7575638-1 1995 Phenobarbital-dependent induction of mouse cytochrome P-450 (Cyp) orthologous to rat CYP2B1 and its modulation by hepatotrophic growth factors were examined in primary hepatocyte cultures. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 43-59 7575638-1 1995 Phenobarbital-dependent induction of mouse cytochrome P-450 (Cyp) orthologous to rat CYP2B1 and its modulation by hepatotrophic growth factors were examined in primary hepatocyte cultures. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 61-64 1552174-0 1992 Relation between cytochrome P-450 increase and endoplasmic reticulum proliferation in hepatocytes of mice treated with phenobarbital: a microphotometric and morphometric study. Phenobarbital 119-132 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 17-33 2268369-1 1990 Polyclonal antibodies generated to four distinct mouse liver phenobarbital-inducible cytochrome P450 isoforms were used to analyse related forms in human liver. Phenobarbital 61-74 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 85-100 8907578-5 1996 In phenobarbital-treated mice, interferon beta reduced the induction of total cytochrome P-450 (22%), the activities of pentoxyresorufin O-dealkylase (38%), benzyloxyresorufin O-dealkylase (30%), erythromycin N-demethylase (30%), 7-ethoxycoumarin O-deethylase (16%) and cytochrome P-450 2B1 (33%) and 3A (45%) proteins. Phenobarbital 3-16 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 78-94 1933335-9 1991 MPTP toxicity was potentiated significantly in brain slices prepared from mice pretreated with phenobarbital, an inducer of cytochrome P-450. Phenobarbital 95-108 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 124-140 2212619-1 1990 To obtain detailed information on the increase of cytochrome P-450 (P-450) content in periportal, midzonal, and perivenular hepatocytes after phenobarbital (PB) administration, and to study the mechanism of increased P-450 in the endoplasmic reticulum (ER), we estimated microphotometrically the P-450 content and morphometrically the area of ER in hepatocytes of three zones from mice injected with 35, 50, 100, or 150 mg/kg of PB for 3 days. Phenobarbital 157-159 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 50-66 2212619-1 1990 To obtain detailed information on the increase of cytochrome P-450 (P-450) content in periportal, midzonal, and perivenular hepatocytes after phenobarbital (PB) administration, and to study the mechanism of increased P-450 in the endoplasmic reticulum (ER), we estimated microphotometrically the P-450 content and morphometrically the area of ER in hepatocytes of three zones from mice injected with 35, 50, 100, or 150 mg/kg of PB for 3 days. Phenobarbital 142-155 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 50-66 2242403-4 1990 Phenobarbital doses of 3 x 0.05 mg per mouse increased the concentration of cytochrome P-450 and ketone groups on PE, whereas the vaccine Propionibacterium acnes (0.5 mg) and its pyridine fraction (0.5 and 1 mg) had the opposite effect. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 76-92 2369784-3 1990 Animals were either untreated or treated with the cytochrome P-450 inducers phenobarbitone, beta-napthoflavone or clofibrate. Phenobarbital 76-90 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 50-66 2117068-4 1990 A monoclonal antibody (MAb 1-7-1), which recognizes isozymes of cytochrome P-450 induced by 3-methylcholanthrene (P1-450 and P3-450), selectively inhibited the metabolism of 8-MOP (-57%) and covalent binding of its metabolites (-40%) in microsomes from mice pretreated with BNF, but had no effect in microsomes of mice pretreated with phenobarbital or vehicle. Phenobarbital 335-348 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 64-80 2319474-5 1990 Inducers of cytochrome P-450 enhanced phenytoin covalent binding as follows: phenobarbital greater than 3-methylcholanthrene greater than saline-treated controls. Phenobarbital 77-90 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 12-28 2369784-8 1990 This data indicated that different amounts or forms of cytochrome P-450s were responsible for warfarin metabolism after phenobarbitone treatment in the two strains. Phenobarbital 120-134 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 55-71 2819695-9 1989 In all 4 types of mice after 4 and 28 days of treatment, PB increased the concentration of cytochrome P-450, the activity of aminopyrine-N-demethylase (AmDm) and 7-ethoxyresorufin-O-deethylase (ErDe) and the oxidation of testosterone (T). Phenobarbital 57-59 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 91-107 20702222-7 1990 The use of S-9 fractions from animals pretreated with phenobarbitone and beta-naphthoflavone resulted in greatly increased phorone toxicity, which indicates the involvement of cytochrome P-450 enzymes in its metabolism. Phenobarbital 54-68 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 176-192 2804321-4 1989 Phenobarbital and perfluorodecalin induce several cytochrome P-450 isozymes and cause the appearance of a new isozyme with mass 56 kD absent in microsomes of intact CBA mice. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 50-66 2779523-4 1989 Because of the many similarities between the CBD-induced isozyme and certain other isozymes previously purified from PB-pretreated animals, a cytochrome P-450 isozyme was purified from PB-pretreated mice by a chromatographic procedure similar to that employed for purification of the CBD-induced isozyme. Phenobarbital 185-187 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 142-158 2803241-6 1989 Antiserum raised to the phenobarbital-inducible form of rat liver cytochrome P-450 [P-450(b+e)] inhibited mouse brain aminopyrine N-demethylase activity by around 80+ mouse brain microsomal protein exhibited cross-reactivity against this antiserum when examined by Ouchterlony double diffusion and immunoblotting. Phenobarbital 24-37 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 66-82 2803241-7 1989 The present results indicate the presence of a phenobarbital-inducible form of cytochrome P-450 (or a form of cytochrome P-450 that is similar immunologically) in mouse brain microsomes, which is associated with a sex-related difference. Phenobarbital 47-60 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 79-95 2803241-7 1989 The present results indicate the presence of a phenobarbital-inducible form of cytochrome P-450 (or a form of cytochrome P-450 that is similar immunologically) in mouse brain microsomes, which is associated with a sex-related difference. Phenobarbital 47-60 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 110-126 3058117-3 1988 To examine the role of constitutive factors in cytochrome P-450 regulation, the levels of three distinct groups of phenobarbital-inducible hepatic cytochrome P-450s were studied following dexamethasone-treatment or hypophysectomy. Phenobarbital 115-128 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 147-163 2804167-0 1989 [The effect of phenobarbital and amidopyrine on the rate of decomposition of isoforms of cytochrome P-450 in mouse liver microsomes]. Phenobarbital 15-28 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 89-105 2804167-3 1989 Phenobarbital treatment causes both the appearance of a new cytochrome P-450 isozyme with a molecular mass of 56 kDa and the increase in the content of three isozymes with molecular masses of 54, 52.5 and 50 kDa. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 60-76 2804167-4 1989 The half-life time of cytochrome P-450 isozymes in the livers of intact and phenobarbital-induced mice differs from 15 to 42 hours. Phenobarbital 76-89 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 22-38 2804167-6 1989 Aminopyrine injections to phenobarbital-pretreated mice result in the breakdown acceleration of the cytochrome P-450 isozyme with a molecular mass of 56 kDa. Phenobarbital 26-39 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 100-116 2462160-5 1988 Treatment with phenobarbital resulted in enhancement of cytochrome P-450 that was visualized in hepatocytes in all regions of the lobule. Phenobarbital 15-28 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 56-72 2903743-0 1988 Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. Phenobarbital 110-123 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 14-30 3219345-1 1988 The constitutive expression of phenobarbital-inducible mouse cytochrome P-450 (I-P-450(16 alpha) at the mRNA level and its associated testosterone 16 alpha-hydroxylase activity in liver microsomes was a female characteristic in many inbred mice, including BALB/cJ, A/HeJ, and C57BL/6J. Phenobarbital 31-44 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 61-95 3390203-2 1988 These results indicate that the 3-MC-inducible form of cytochrome P-450 was more susceptible to CS2 than the PB-inducible form. Phenobarbital 109-111 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 55-71 2451633-3 1988 The aim of this study was to assess the expression of the phenobarbital-inducible cytochrome P-450 b,e genes in hepatocytes of the right and left fetal liver lobes in mice. Phenobarbital 58-71 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 82-98 3370247-0 1988 [Comparison of cytochrome P-450 forms induced by phenobarbital and 1,4-bis[3,5-dichloropyridyloxy)]benzene in the mouse and rat liver]. Phenobarbital 49-62 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 15-31 3370247-1 1988 A form of cytochrome P-450 (P-450PB) with a molecular weight of 53.5-54.0 kD possessing a high benzphetamine-N-demethylase activity (100-120 nmol formaldehyde/min/nmol cytochrome) was isolated from liver microsomes of phenobarbital-induced C57Bl/6 mice. Phenobarbital 218-231 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 10-26 3354230-5 1988 The FAD-containing mono-oxygenase catalysed the formation of (-)-phorate sulphoxide, while two cytochrome P-450 isozymes (cytochrome P-450-B2, a constitutive form, and cytochrome P-450-PB, the principal form induced by phenobarbital) produced (+)-phorate sulphoxide. Phenobarbital 219-232 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 95-111 3030329-3 1987 The formation of DHVP-16 was cytochrome P-450-mediated as indicated by its dependence on NADPH, its increased production following treatment of mice with phenobarbital, and its marked inhibition by SKF-525A and piperonyl butoxide. Phenobarbital 154-167 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 29-45 3564013-3 1987 Phenobarbital not only significantly induced hepatic microsomal cytochrome P-450 (p less than 0.05) but also increased microsomal carboxylesterase activity (p less than 0.05). Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 64-80 3629598-5 1987 Phenobarbital pretreatment of mice induced hepatic cytochrome P-450 content, as well as microsomal activation of azinphos-methyl in vitro, yet antagonized the acute toxicity of this pesticide in vivo. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 51-67 3271881-2 1986 The involvement of cytochrome P-450 (P-450) as the catalyst in 2NP denitrification was revealed by the induction of nitrite-releasing activity following phenobarbital (PB) pretreatment, by a decrease in activity with carbon tetrachloride pretreatment, by the inhibition of the reaction with classical P-450 inhibitors, and by the observation of a type I binding spectrum. Phenobarbital 153-166 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 19-35 3806412-1 1987 Pretreatment of mice with multiple doses of phenobarbital (PB) potentiates N-acetyl-para-aminophenol (APAP) hepatotoxicity through induction of cytochrome P-450, thus increasing the formation of APAP-reactive metabolites. Phenobarbital 44-57 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 144-160 3806412-1 1987 Pretreatment of mice with multiple doses of phenobarbital (PB) potentiates N-acetyl-para-aminophenol (APAP) hepatotoxicity through induction of cytochrome P-450, thus increasing the formation of APAP-reactive metabolites. Phenobarbital 59-61 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 144-160 2833324-2 1987 The results showed that PB treatment increased the amount of liver total cytochrome P450 (cytP450), a drug metabolizing monooxygenase enzyme in genetically obese, hyperglycemic (ob/ob) mice 6-fold and the total activities of other monooxygenase enzymes NADPH cytP450 reductase and 7-ethoxyresorufin O-deethylase (ERDE) 2- and 6.5-fold, respectively. Phenobarbital 24-26 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 73-88 2833324-2 1987 The results showed that PB treatment increased the amount of liver total cytochrome P450 (cytP450), a drug metabolizing monooxygenase enzyme in genetically obese, hyperglycemic (ob/ob) mice 6-fold and the total activities of other monooxygenase enzymes NADPH cytP450 reductase and 7-ethoxyresorufin O-deethylase (ERDE) 2- and 6.5-fold, respectively. Phenobarbital 24-26 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 90-97 2833324-2 1987 The results showed that PB treatment increased the amount of liver total cytochrome P450 (cytP450), a drug metabolizing monooxygenase enzyme in genetically obese, hyperglycemic (ob/ob) mice 6-fold and the total activities of other monooxygenase enzymes NADPH cytP450 reductase and 7-ethoxyresorufin O-deethylase (ERDE) 2- and 6.5-fold, respectively. Phenobarbital 24-26 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 259-266 3764930-2 1986 Daily pretreatment of mice with phenobarbital (80 mg/kg, ip) for 4 days induced hepatic cytochrome P-450 content, as well as oxidative activation and oxidative detoxification of parathion, as measured in vitro. Phenobarbital 32-45 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 88-104 3764930-5 1986 These results indicate that phenobarbital pretreatment clearly induces that form(s) of cytochrome P-450 catalyzing conversion of parathion to PO. Phenobarbital 28-41 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 87-103 3271881-2 1986 The involvement of cytochrome P-450 (P-450) as the catalyst in 2NP denitrification was revealed by the induction of nitrite-releasing activity following phenobarbital (PB) pretreatment, by a decrease in activity with carbon tetrachloride pretreatment, by the inhibition of the reaction with classical P-450 inhibitors, and by the observation of a type I binding spectrum. Phenobarbital 168-170 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 19-35 3106031-2 1987 After chronic ethanol consumption, microsomal ethanol-oxidizing system (MEOS) activity increases with an associated rise in microsomal cytochrome P-450, including a form different from that induced by phenobarbital and methylcholanthrene and which has a high affinity for ethanol, as shown in reconstituted systems. Phenobarbital 201-214 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 135-151 3707601-3 1986 Purified phenobarbital-induced cytochrome P-450 produced more oxide per nmole enzyme than any of the purified uninduced cytochrome P-450s. Phenobarbital 9-22 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 31-47 3707601-5 1986 Diethylphenylphosphine bound to oxidized purified phenobarbital-induced cytochrome P-450 and uninduced cytochrome P-450 with Ks values of 16 microM and 11-18 microM respectively. Phenobarbital 50-63 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 72-88 3707601-5 1986 Diethylphenylphosphine bound to oxidized purified phenobarbital-induced cytochrome P-450 and uninduced cytochrome P-450 with Ks values of 16 microM and 11-18 microM respectively. Phenobarbital 50-63 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 103-119 3707601-6 1986 Diethylphenylphosphine was also a competitive inhibitor of p-nitroanisole O-demethylation catalyzed by a reconstituted phenobarbital-induced cytochrome P-450-dependent monooxygenase system, with a Ki value of 5 microM. Phenobarbital 119-132 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 141-157 3012058-11 1986 The metabolic rate (per nmol cytochrome P-450) of CBD was also increased significantly by phenobarbital-treatment but not by 3-methylcholanthrene-treatment. Phenobarbital 90-103 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 29-45 2422427-1 1986 In vivo treatment of randombred Swiss Webster mice with polyriboinosinic-polyribocytidylic acid (poly l X poly C) inhibited the induction of cytochrome P-450"s by both 3-methylcholanthrene [(MCA) CAS: 56-49-5] and phenobarbitol [(PB) CAS: 50-06-6]. Phenobarbital 214-227 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 141-157 3731348-0 1986 Different depressing effects of lentinan on the increases of cytochrome P-450-dependent monooxygenase activities induced in mice by phenobarbital and by 3-methylcholanthrene. Phenobarbital 132-145 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 61-77 3753840-1 1986 Using specific testosterone 16 alpha-hydroxylase activity as the basis for selection of fractions during purification, the cytochrome P-450 ("I"-P-450(16)alpha) has been isolated from livers of phenobarbital-treated 129/J female mice [K. Devore, N. Harada, and M. Negishi (1985) Biochemistry, 24, 5632-5637]. Phenobarbital 194-207 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 123-159 3947732-1 1986 The effect of liver monooxygenase system substrates upon the rate of cytochrome P-450 isoform degradation was investigated by measuring the half-life of liver microsomal proteins in C57BL/6 mice injected with phenobarbital and then 24 hours later with aminopyrine every 6 hours. Phenobarbital 209-222 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 69-85 3947732-2 1986 The rate of phenobarbital-induced degradation of cytochrome P-450 isoform (mol weight 56000 daltons) was shown to be increased two-fold. Phenobarbital 12-25 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 49-65 3012058-12 1986 These results suggest that CBD metabolites rather than CBD itself, play some role in the decreasing effect on cytochrome P-450 content in the hepatic microsomes in vitro, and that the microsomal formation of reactive metabolite of CBD is increased by phenobarbital-treatment. Phenobarbital 251-264 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 110-126 4074718-1 1985 Cytochrome P-450 (I-P-450(16) alpha), which is associated with phenobarbital-induced testosterone 16 alpha-hydroxylation activity, was purified from livers of phenobarbital-treated female 129/J mice on the basis of the specific hydroxylation activity in fractions eluted from columns of octylamino-Sepharose 4B, hydroxylapatite, DEAE-Bio-Gel A, and isobutyl-Sepharose 4B. Phenobarbital 63-76 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-35 4074718-1 1985 Cytochrome P-450 (I-P-450(16) alpha), which is associated with phenobarbital-induced testosterone 16 alpha-hydroxylation activity, was purified from livers of phenobarbital-treated female 129/J mice on the basis of the specific hydroxylation activity in fractions eluted from columns of octylamino-Sepharose 4B, hydroxylapatite, DEAE-Bio-Gel A, and isobutyl-Sepharose 4B. Phenobarbital 159-172 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-35 6698172-2 1984 Moreover, dinemorphan N-demethylation is inhibited by CO, SKF-525A, metyrapone and it is specifically catalyzed by a phenobarbital-inducible form of cytochrome P-450. Phenobarbital 117-130 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 149-165 3966918-4 1985 After oral applications of 120 mg/kg warfarin once daily for three days SDS-PAGE analysis of the partially purified cytochrome P-450 fraction revealed a protein pattern in the 50 Kd region that is practically indistinguishable from that after conventional phenobarbitone pretreatment. Phenobarbital 256-270 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 116-132 6331534-0 1984 [Isolation and characterization of the basic forms of cytochrome P-450 from liver microsomes of C57BL mice after phenobarbital and 3-methylcholanthrene induction]. Phenobarbital 113-126 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 54-70 2861996-4 1985 The administration of the inducers, phenobarbital or the polychlorinated biphenyl mixture Aroclor 1254, resulted in significant increases in cytochrome P-450 and ethylmorphine N-demethylase activity and minimal changes in benzo(a)pyrene hydroxylase activity in both strains. Phenobarbital 36-49 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 141-157 2861996-9 1985 The latter strain appeared to be more responsive to the inducing properties of the phenobarbital class of inducers, as reflected in the inducibility of cytochrome P-450 and the associated enzymic activities in the liver. Phenobarbital 83-96 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 152-168 6437140-5 1984 The cytochrome P-450 inducer phenobarbital moderately (PER 152%) increased the rate of 14CO2-formation from PCDD II, whereas 3-methylcholanthrene and several technical grade chlorinated paraffins generally gave less or no inductive effects. Phenobarbital 29-42 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 4-20 6701911-1 1984 Vinylcyclooctane (VCO), which binds to the active site of cytochrome P-450 (P-450) giving a type I difference spectrum, has been found to form the corresponding epoxide as the main metabolite on treatment with liver microsomal monooxygenase obtained from phenobarbital-treated or untreated mice. Phenobarbital 255-268 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 58-74 947901-0 1976 Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice. Phenobarbital 108-121 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 62-78 6408471-5 1983 The contents of liver microsomal cytochrome p-450 of mice pretreated with PB or MC were about twice those of non-treated mice. Phenobarbital 74-76 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 33-49 6120697-3 1982 Significant destruction of cytochrome P-450 was observed when alclofenac was incubated with microsomes from mice pretreated with PB but not from untreated or 3-MC-treated mice. Phenobarbital 129-131 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 27-43 7269901-2 1981 These substances, acting as inductors of microsomal oxidases with mixed function (cytochrome P-450 and P-448), are phenobarbital, 3-methylcholanthrene, DDT, diphenin, rifampicin, benzodiazepin derivatives (diazepam and phenazepam). Phenobarbital 115-128 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 82-108 7389009-4 1980 The capacity of isosafrole and piperonyl butoxide to induced cytochrome P-450 was evaluated by measurement of biphenyl 2- and 4-hydroxylase, ethoxyresofurin O-deethylase and ethylmorphine N-demethylase and by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis and compared with results obtained for phenobarbitone, 3-methylcholanthrene and pregnenolone-16 alpha-carbonitrile. Phenobarbital 313-327 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 61-77 461991-2 1979 Subsequent induction of microsomal metabolism by 50 mg phenobarbital/kg.day over 5 days revealed increased microsomal cytochrome P 450 content in Cd+2-pretreated animals as compared to animals treated only with phenobarbital. Phenobarbital 55-68 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 118-134 6418176-4 1983 Cytochrome P-450-dependent S-oxidation of thiobenzamide was induced in the liver by treatment of mice with phenobarbital and slightly increased by treatment with 3-methylcholanthrene, while in rat liver either of these treatments caused only a small increase in metabolism due to cytochrome P-450. Phenobarbital 107-120 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-16 6309775-0 1983 Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice. Phenobarbital 28-41 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 52-68 6309775-1 1983 Southern blot analysis suggests that multiple sequences homologous to a phenobarbital-inducible cytochrome P-450 cDNA are present in the rat and mouse genomes. Phenobarbital 72-85 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 96-112 6309775-2 1983 A cDNA (pP-450b-5) to a major phenobarbital-inducible cytochrome P-450 mRNA species in the rat detected 6 polymorphic DNA fragments when hybridized to DNA from C57BL/6J and DBA/2J mice restricted with endonucleases EcoRI, BamHI, and PvuII. Phenobarbital 30-43 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 54-70 6309775-4 1983 The Coh locus has previously been shown to code for a phenobarbital-inducible enzyme, believed to be a cytochrome P-450, which catalyzes the conversion of coumarin to 7-hydroxycoumarin (umbelliferone). Phenobarbital 54-67 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 103-119 7080065-11 1982 and that this inhibition is enhanced by the cytochrome P-450-inducing agent phenobarbital. Phenobarbital 76-89 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 44-60 716947-1 1978 Cytochrome P-450 in mouse liver microsomes was characterized by SDS-polyacrylamide gel electrophoresis after intraperitoneal injection of 80 mg phenobarbital, 4.5 and 45 mg acrylamide and 60 and 600 mg methylmethacrylate per kg body weight each day for four days. Phenobarbital 144-157 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-16 716947-3 1978 The amount of cytochrome P-450 with a molecular weight of 47,000 (MLvMcP-450(47) decreased in the phenobarbital group and in both acrylamide groups. Phenobarbital 98-111 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 14-30 716947-5 1978 The cytochrome P-450 form with a molecular weight of 50,000 (MLvMcP-450(50) was significantly increased only in the phenobarbital group. Phenobarbital 116-129 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 4-20 716947-6 1978 An increase in the total amount of cytochrome P-450 was only observed following treatment with phenobarbital. Phenobarbital 95-108 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 35-51 947901-4 1976 All four fractions with respect to their spectral and catalytic properties, thereby demonstrating that mouse liver microsomes from phenobarbital-treated hybrid mice contain at least four forms of cytochrome P-450. Phenobarbital 131-144 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 196-212 24180433-2 2014 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 76-91 820074-2 1976 Phenobarbital and medinal administration resulted in a 2-8 fold increase in cytochrome P-450 amount. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 76-92 26400395-0 2015 Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver. Phenobarbital 8-21 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 109-124 1254598-4 1976 In contrast, phenobarbital or pregnenolone-16 alpha-carbonitrile induces in both responsive and nonresponsive strains a different profile of enzyme activities and the appearance of cytochrome P-450 (rather than cytochrome P-448). Phenobarbital 13-26 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 181-197 24180433-2 2014 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital 0-13 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 93-96 24180433-2 2014 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital 15-17 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 76-91 24180433-2 2014 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital 15-17 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 93-96 23475686-3 2013 The cells are viable, can be transfected by DNA, and retain key properties of liver cells such as the induction of cytochrome P450 gene expression by drugs such as phenobarbital. Phenobarbital 164-177 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 115-130