PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17158155-0	2007	Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.	troxacitabine	80-93	deoxycytidine kinase	Homo sapiens	103-123	
17158155-3	2007	Herein, we report the crystal structures of human deoxycytidine kinase (dCK) in complex with the L-nucleosides (-)-beta-2",3"-dideoxy-3"-thiacytidine (3TC)--an approved anti-human immunodeficiency virus (HIV) agent--and troxacitabine (TRO)--an experimental anti-neoplastic agent.	troxacitabine	220-233	deoxycytidine kinase	Homo sapiens	50-70	
17158155-3	2007	Herein, we report the crystal structures of human deoxycytidine kinase (dCK) in complex with the L-nucleosides (-)-beta-2",3"-dideoxy-3"-thiacytidine (3TC)--an approved anti-human immunodeficiency virus (HIV) agent--and troxacitabine (TRO)--an experimental anti-neoplastic agent.	troxacitabine	235-238	deoxycytidine kinase	Homo sapiens	50-70	
18058539-1	2007	Troxacitabine is a cytotoxic deoxycytidine analogue with an unnatural L-configuration, which is activated by deoxycytidine kinase (dCK).	troxacitabine	0-13	deoxycytidine kinase	Homo sapiens	109-129	
15266019-8	2004	One explanation that emerged from enzyme assays of deoxycytidine kinase (dCK) and deoxycytidine monophosphate kinase (dCMPK), key enzymes involved in L-OddC phosphorylation, was that CPT protected against L-OddC-induced reduction in dCK and dCMPK activity.	troxacitabine	150-156	deoxycytidine kinase	Homo sapiens	51-71	
17065050-1	2006	Troxacitabine is a cytotoxic deoxycytidine analogue with an unnatural L-configuration, which is activated by deoxycytidine kinase (dCK).	troxacitabine	0-13	deoxycytidine kinase	Homo sapiens	109-129	
11585758-3	2001	The CCRF-CEM leukemia cell line was highly sensitive to the antiproliferative effects of troxacitabine, gemcitabine, and cytarabine with inhibition of proliferation by 50% observed at 160, 20, and 10 nM, respectively, whereas a deoxycytidine kinase (dCK)-deficient variant (CEM/dCK(-)) was resistant to all three drugs.	troxacitabine	89-102	deoxycytidine kinase	Homo sapiens	228-248