PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34648192-9	2022	CONCLUSION: CYP1A2 is the major CYP for the conversion of 4-MAA to 4-AA and 4-FAA.	4-maa	58-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-35	
29746911-3	2018	Previous studies suggested that 4-MAA demethylation can be performed by hepatic cytochrome P450 (CYP) 3A4, but the possible contribution of other CYPs remains unclear.	4-maa	32-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-95	
29746911-3	2018	Previous studies suggested that 4-MAA demethylation can be performed by hepatic cytochrome P450 (CYP) 3A4, but the possible contribution of other CYPs remains unclear.	4-maa	32-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	97-100	
29746911-5	2018	Based on CYP induction (HepaRG cells) and CYP inhibition (HLM) we could identify CYP2B6, 2C8, 2C9 and 3A4 as major contributors to 4-MAA demethylation.	4-maa	131-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	9-12	
29746911-5	2018	Based on CYP induction (HepaRG cells) and CYP inhibition (HLM) we could identify CYP2B6, 2C8, 2C9 and 3A4 as major contributors to 4-MAA demethylation.	4-maa	131-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-45	
34648192-2	2022	The primary metabolite, 4-methylaminoantipyrine (4-MAA), can be N-demethylated to 4-aminoantipyrine (4-AA) or oxidized to 4-formylaminoantipyrine (4-FAA) by cytochrome P450 (CYP)-dependent reactions.	4-maa	49-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-172	
34648192-2	2022	The primary metabolite, 4-methylaminoantipyrine (4-MAA), can be N-demethylated to 4-aminoantipyrine (4-AA) or oxidized to 4-formylaminoantipyrine (4-FAA) by cytochrome P450 (CYP)-dependent reactions.	4-maa	49-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	174-177	
34648192-3	2022	We aimed to identify the CYPs involved in 4-MAA metabolism and to quantify the effect of CYP inhibition on 4-MAA metabolism.	4-maa	107-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-92	
34648192-4	2022	METHODS: We investigated the metabolism of 4-MAA in vitro using CYP expressing supersomes and the pharmacokinetics of metamizole in the presence of CYP inhibitors in male subjects.	4-maa	43-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-67	
34648192-5	2022	RESULTS: The experiments in supersomes revealed CYP1A2 as the major CYP for 4-MAA N-demethylation and 4-FAA formation with CYP2C19 and CYP2D6 contributing to N-demethylation.	4-maa	76-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-71