PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28679023-2	2017	The effect of itraconazole (a strong CYP3A inhibitor) on the pharmacokinetics of etizolam (a substrate of CYP2C19 and CYP3A) was assessed in both extensive metabolizers (EMs) and poor metabolizers (PMs) of CYP2C19.	etizolam	81-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-123	
15232663-0	2004	Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism.	etizolam	110-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	100-106	
16141545-5	2005	In addition, the metabolic activities of diazepam, clotiazepam, and etizolam in human liver microsomes were inhibited by 2.5 microM ketoconazole, a CYP3A4 inhibitor, by 97.5%, 65.1%, and 83.5%, respectively, and the imipramine metabolism was not detected after the addition of 1 or 10 microM quinidine, a CYP2D6 inhibitor.	etizolam	68-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	148-154	
15232663-1	2004	OBJECTIVE: To clarify the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of etizolam.	etizolam	88-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-66	
15232663-9	2004	CONCLUSION: The present study suggests that itraconazole inhibits the metabolism of etizolam, providing evidence that CYP3A4 is at least partly involved in etizolam metabolism.	etizolam	84-92	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124	
15232663-9	2004	CONCLUSION: The present study suggests that itraconazole inhibits the metabolism of etizolam, providing evidence that CYP3A4 is at least partly involved in etizolam metabolism.	etizolam	156-164	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124