PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18065768-7 2008 alpha-Naphthoflavone, an AhR antagonist, and a small interfering RNA (siRNA) for AhR significantly suppressed SS-induced CYP1A1 expression. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-127 18059023-7 2008 AF increased intracellular ROS, an effect blocked by NAC and the CYP1A1/1A2 inhibitor, alpha-Naphthoflavone (alpha-NF). alpha-naphthoflavone 87-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 18059023-7 2008 AF increased intracellular ROS, an effect blocked by NAC and the CYP1A1/1A2 inhibitor, alpha-Naphthoflavone (alpha-NF). alpha-naphthoflavone 109-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 15766918-8 2005 alpha-Naphthoflavone, an inhibitor of human CYP1A1 and CYP1A2, did not completely inhibit the liver microsomal oxidations of ER and PN even at the highest concentration (50muM), supporting the notion that CYP1A2 enzymes are not the sole ER or PN O-deethylase in Japanese monkey and marmoset liver microsomes. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 14962508-8 2004 Meanwhile, because TCDD- and PCB126-enhanced CYP1A1 and CYP1B1 expressions were significantly reduced by the AhR antagonist and CYP1 inhibitor alpha-naphthoflavone (ANF), this indicated that the effects of TCDD and PCB126 were AhR and cytochrome p450 1 dependent. alpha-naphthoflavone 143-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 15081398-4 2004 Such deleterious effects were associated with BP metabolite production, whose inhibition by the cytochrome P-450 1A1 inhibitor alpha-naphthoflavone fully abolished BP toxicity. alpha-naphthoflavone 127-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-116 14962508-8 2004 Meanwhile, because TCDD- and PCB126-enhanced CYP1A1 and CYP1B1 expressions were significantly reduced by the AhR antagonist and CYP1 inhibitor alpha-naphthoflavone (ANF), this indicated that the effects of TCDD and PCB126 were AhR and cytochrome p450 1 dependent. alpha-naphthoflavone 143-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-49 14962508-8 2004 Meanwhile, because TCDD- and PCB126-enhanced CYP1A1 and CYP1B1 expressions were significantly reduced by the AhR antagonist and CYP1 inhibitor alpha-naphthoflavone (ANF), this indicated that the effects of TCDD and PCB126 were AhR and cytochrome p450 1 dependent. alpha-naphthoflavone 165-168 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 14962508-8 2004 Meanwhile, because TCDD- and PCB126-enhanced CYP1A1 and CYP1B1 expressions were significantly reduced by the AhR antagonist and CYP1 inhibitor alpha-naphthoflavone (ANF), this indicated that the effects of TCDD and PCB126 were AhR and cytochrome p450 1 dependent. alpha-naphthoflavone 165-168 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-49 12495659-8 2003 After induction with 1,2-benzanthracene, the CYP1A1 selective inhibitor, alpha-naphthoflavone, and the CYP1A2 selective inhibitor, furafylline, effectively inhibited enzyme activities with IC(50)s of 2.4 microM and 12.8 microM, respectively, in microsomes from both trophoblasts culture systems. alpha-naphthoflavone 73-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 12147246-0 2002 Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone. alpha-naphthoflavone 69-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 12147246-6 2002 alpha-Naphthoflavone, which is known as an antagonist to 2,3,7,8-tetrachlorodibenzo-p-dioxin, inhibited the inductions of heme oxygenase 1, glutamate-cysteine ligase (modifier unit), and thioredoxin reductase by beta-naphthoflavone but not those of CYP1A1 and CYP1A2. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 249-255 12023534-4 2002 CYP1A1 debrisoquine 4-hydroxylase was inhibited by the CYP1A1 inhibitor alpha-naphthoflavone and the CYP1A1 substrate 7-ethoxyresorufin. alpha-naphthoflavone 72-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 12023534-4 2002 CYP1A1 debrisoquine 4-hydroxylase was inhibited by the CYP1A1 inhibitor alpha-naphthoflavone and the CYP1A1 substrate 7-ethoxyresorufin. alpha-naphthoflavone 72-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 12023534-4 2002 CYP1A1 debrisoquine 4-hydroxylase was inhibited by the CYP1A1 inhibitor alpha-naphthoflavone and the CYP1A1 substrate 7-ethoxyresorufin. alpha-naphthoflavone 72-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 11082432-7 2000 The cytochrome P450 (CYP) 1A1 inhibitor alpha-naphthoflavone inhibited the metabolism of all-trans-RA, whereas the CYP1A1 inducer beta-naphthoflavone induced the metabolism of all-trans-RA, suggesting that CYP1A1 is involved. alpha-naphthoflavone 40-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-29 11768231-4 2001 Since part of AhR is activated into DNA binding species in the absence of exogenous ligand and competitive AhR antagonist alpha-naphthoflavone inhibits this activation process with reducing CYP1A1 mRNA expression levels, the presence of endogenous ligand is indicated. alpha-naphthoflavone 122-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 190-196 12127040-10 2002 CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM). alpha-naphthoflavone 112-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 12127040-10 2002 CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM). alpha-naphthoflavone 134-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 12127040-10 2002 CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM). alpha-naphthoflavone 254-257 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 10875683-6 2000 Alpha-naphtoflavone and isosafrole, CYP1A1/2 inhibitors, suppressed the metabolism of YM992 in human liver microsomes in a concentration-dependent manner. alpha-naphthoflavone 0-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 10964100-8 2000 The CYP1 inhibitor alpha-naphthoflavone (10 microM) reduced B[a]P-DNA adduct formation in tissues from two individuals by 96 and 64%, respectively. alpha-naphthoflavone 19-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 10534316-8 1999 However, alpha-naphthoflavone inhibited the same reaction by approximately 70%, suggesting that CYP1A1 and/or CYP1B1 may also catalyze the reaction substantially. alpha-naphthoflavone 9-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 10473105-5 1999 The most potent inhibitors of DTIC N-demethylation were alpha-naphthoflavone (CYP1A1 and CYP1A2), quercetin (CYP1A2), chlorzoxazone (CYP1A2 and CYP2E1), and di-sulfiram (CYP2E1). alpha-naphthoflavone 56-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84 9890552-5 1999 Moreover, alpha-naphthoflavone, a partial aryl hydrocarbon receptor (AhR) antagonist, and 8-methoxypsoralen, which interferes with the binding of activated AhR to the xenobiotic responsive element, were shown to suppress CYP1A1 induction when added to the cultures. alpha-naphthoflavone 10-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 221-227 8818577-4 1996 Selective cytochrome P450 inhibitors for CYP1A1/2 (furafylline and 7,8-benzoflavone) and CYP3A4 (troleandomycin, gestodene, and ketoconazole) inhibited the formation of desmethylcyclobenzaprine, a major metabolite of cyclobenzaprine, in human liver microsomes. alpha-naphthoflavone 67-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 9093392-9 1997 Cytochrome P450 CYP1A1, present constitutively only in h1A1v2 cells, was implicated in 2-NF activation because mutagenicity was reduced by 55-80% when alpha-naphthoflavone (ANF) was present during incubation. alpha-naphthoflavone 151-171 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-22 9093392-9 1997 Cytochrome P450 CYP1A1, present constitutively only in h1A1v2 cells, was implicated in 2-NF activation because mutagenicity was reduced by 55-80% when alpha-naphthoflavone (ANF) was present during incubation. alpha-naphthoflavone 173-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-22 9089421-5 1997 alpha-Naphthoflavone (a CYP1A1/2 inhibitor only at concentrations < 2 mumol/L and a CYP2C9 inhibitor at higher concentrations) had a weak inhibitory effect on ethinyl estradiol formation (< 20% decrease in mestranol demethylation activity). alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 9105404-4 1997 The two flavones, alpha-naphthoflavone and apigenin, while differing in potency, inhibited expressed human CYP1A1, CYP1A2, and human liver microsomes to a similar extent. alpha-naphthoflavone 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 8759031-6 1996 Cotreatment with alpha-naphthoflavone (alpha NF, 1 microM) or ellipticine (ELLIP, 0.1 nM) only partially inhibited the induction of AHH activity by BaP (30 microM). alpha-naphthoflavone 17-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-135 8759031-6 1996 Cotreatment with alpha-naphthoflavone (alpha NF, 1 microM) or ellipticine (ELLIP, 0.1 nM) only partially inhibited the induction of AHH activity by BaP (30 microM). alpha-naphthoflavone 39-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-135 9774143-5 1998 This inhibiting effect was not dependent on the CYP1A1 activity, as it also occurred in the presence of CYP1A1 inhibitors such as alpha-naphthoflavone, 8-methoxypsoralen or ellipticin. alpha-naphthoflavone 130-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 104-110 9418899-7 1998 Transcriptional activation of the luciferase reporter gene observed in CV-1 cells is significantly decreased by (i) expression of a functional CYP1A1 enzyme, (ii) competition with chimeric or truncated AHR proteins containing the AHR ligand-binding domain, and (iii) treatment with the AHR antagonist alpha-naphthoflavone. alpha-naphthoflavone 301-321 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 9223567-9 1997 Some inhibition was produced by alpha-naphthoflavone, a chemical that inhibits CYP1As and also interacts with CYP3A4. alpha-naphthoflavone 32-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 9169082-5 1997 When alpha-naphthoflavone, a partial Ah receptor (AhR) antagonist, and 8-methoxypsoralen, which interferes with the binding of activated AhR to the xenobiotic responsive element (XRE), were added to the cultures, CYP1A1 induction was suppressed. alpha-naphthoflavone 5-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 213-219 1315629-4 1992 The TCDF induction of a reporter gene construct under the control of the -1140 to +2435 part of the CYPIA1 gene transiently transfected into HK was effectively inhibited by the dioxin-receptor antagonist alpha-naphthoflavone (ANF). alpha-naphthoflavone 204-224 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 7554063-5 1995 alpha-Naphthoflavone, an inhibitor of cytochrome P450 (CYP)1A1, decreased both the formation of diolepoxide metabolites and the p53 response. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-62 7646562-6 1995 7-Ethoxyresorufin-O-dealkylation activity, supported by cytochrome P4501A1, was induced more than 1000-times in Caco-2 cells by beta-naphthoflavone treatment, and this effect was partially abolished by alpha-naphthoflavone treatment. alpha-naphthoflavone 202-222 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-74 7887922-3 1995 Using an AhR antagonist, alpha-naphthoflavone (alpha-NF) and a protein kinase C (PKC) inhibitor, staurosporine (ST), in the Hep G2 cell line, the induced CYP1A1 activity was modulated in the same manner as when the cells were coexposed to TCDD and either alpha-NF or ST. alpha-naphthoflavone 25-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 154-160 7887987-3 1995 By contrast, profound inhibition of the ring hydroxylation of 2-acetylaminofluorene and of the O-deethylation of ethoxyresorufin by 7,8-benzoflavone as well as by anti-cytochrome P4501A1 antibodies indicated the presence of significant levels of functional cytochrome P4501A1 in hepatic microsomes of human embryos. alpha-naphthoflavone 132-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 257-275 8474022-4 1993 The prototypic CYP1A xenobiotic inhibitor and substrate probes alpha-naphthoflavone, ellipticine, 7-ethoxycoumarin and 7-ethoxyresorufin all inhibited CYP1A1- and CYP1A2-mediated phenacetin O-deethylation as well as the high-affinity component of human liver phenacetin O-deethylase activity. alpha-naphthoflavone 63-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-157 8474022-5 1993 alpha-Naphthoflavone and 7-ethoxycoumarin were, however, approximately 10-fold more potent as inhibitors of CYP1A2 than CYP1A1. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 120-126 7640150-4 1995 alpha-Naphthoflavone and 7-ethoxyresorufin (selective inhibitors of CYP1A1/2) inhibited the N-desisopropylation of R- and S-propranolol by human liver microsomes by 20 and 40%, respectively, while quinidine (a selective inhibitor of CYP2D6) abolished the 4-hydroxylation of both propranolol enantiomers almost completely. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 8390116-1 1993 alpha-Naphthoflavone (alpha NF) and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) inhibited 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression in MCF-7 human breast cancer cells and also decreased the accumulation of the nuclear [3H]TCDD-aryl hydrocarbon (Ah) receptor complex. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 141-147 8390116-1 1993 alpha-Naphthoflavone (alpha NF) and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) inhibited 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression in MCF-7 human breast cancer cells and also decreased the accumulation of the nuclear [3H]TCDD-aryl hydrocarbon (Ah) receptor complex. alpha-naphthoflavone 22-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 141-147 1329656-2 1992 In contrast, treatment of these cell lines with either alpha-naphthoflavone (alpha NF) or 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) at concentrations as high as 10(-6) M resulted in only minimal induction of CYP1A1 mRNA levels or EROD activity. alpha-naphthoflavone 55-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 210-216 1315629-4 1992 The TCDF induction of a reporter gene construct under the control of the -1140 to +2435 part of the CYPIA1 gene transiently transfected into HK was effectively inhibited by the dioxin-receptor antagonist alpha-naphthoflavone (ANF). alpha-naphthoflavone 226-229 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 34474468-0 2021 Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by alpha-naphthoflavone analogs. alpha-naphthoflavone 92-112 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 34474468-4 2021 It was found that the sustainability of the pi-pi stacking interactions with the phenylalanine residues of the two isoforms, namely, Phe123, Phe224, and Phe258 for CYP1A1, and Phe134, Phe231, and Phe268 for CYP1B1, played a crucial role in determining the selectivity of ligands with a classic aromatic conjugation system like ANF and its derivatives for CYP1B1 versus CYP1A1. alpha-naphthoflavone 327-330 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 164-170 34474468-4 2021 It was found that the sustainability of the pi-pi stacking interactions with the phenylalanine residues of the two isoforms, namely, Phe123, Phe224, and Phe258 for CYP1A1, and Phe134, Phe231, and Phe268 for CYP1B1, played a crucial role in determining the selectivity of ligands with a classic aromatic conjugation system like ANF and its derivatives for CYP1B1 versus CYP1A1. alpha-naphthoflavone 327-330 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 369-375 2509067-9 1989 The correlation of 7,8-diol formation with phenacetin O-deethylation in a set of liver samples and the partial inhibition of the reaction by 7,8-benzoflavone and anti-rat P-450 beta NF-B suggest that the enzyme involved may be P1-450, the human ortholog of rat P-450 beta NF-B, which catalyzes both the formation of B(a)P-7,8-diol and its subsequent oxidation in tissues of polycyclic hydrocarbon-treated rats. alpha-naphthoflavone 141-157 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 227-233 31203411-8 2019 Pretreatment of RT4 cells with alpha-naphthoflavone (1-10 microM), a specific cytochrome P450 1 (CYP1) inhibitor, decreased AalphaC adduct formation by 50% but did not affect the level of 4-ABP adducts. alpha-naphthoflavone 31-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-95 3106806-4 1987 The fact that the constitutive and induced AHH in FL cells could be inhibited by a known hydroxylase inhibitor 7,8-BF indicated that the AHH in FL cells belongs to the cytochrome P-448 dependent MFO type. alpha-naphthoflavone 111-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-46 3106806-4 1987 The fact that the constitutive and induced AHH in FL cells could be inhibited by a known hydroxylase inhibitor 7,8-BF indicated that the AHH in FL cells belongs to the cytochrome P-448 dependent MFO type. alpha-naphthoflavone 111-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-140 32060993-0 2020 Inhibition of human CYP1 enzymes by a classical inhibitor alpha-naphthoflavone and a novel inhibitor N-(3, 5- dichlorophenyl)cyclopropanecarboxamide - an in vitro and in silico study. alpha-naphthoflavone 58-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-24 32060993-3 2020 We characterized inhibition of human CYP1A1, CYP1A2 and CYP1B1 enzymes by the novel inhibitor N-(3,5-dichlorophenyl) cyclopropanecarboxamide (DCPCC) and alpha-naphthoflavone (ANF). alpha-naphthoflavone 153-173 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 32060993-3 2020 We characterized inhibition of human CYP1A1, CYP1A2 and CYP1B1 enzymes by the novel inhibitor N-(3,5-dichlorophenyl) cyclopropanecarboxamide (DCPCC) and alpha-naphthoflavone (ANF). alpha-naphthoflavone 175-178 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 32060993-8 2020 ANF was a competitive tight-binding inhibitor of CYP1A1, CYP1A2 and CYP1B1. alpha-naphthoflavone 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 32060993-10 2020 Molecular dynamics simulations and binding free energy calculations explained the differences of binding of DCPCC and ANF to the active sites of all three CYP1 enzymes. alpha-naphthoflavone 118-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 155-159 31203411-8 2019 Pretreatment of RT4 cells with alpha-naphthoflavone (1-10 microM), a specific cytochrome P450 1 (CYP1) inhibitor, decreased AalphaC adduct formation by 50% but did not affect the level of 4-ABP adducts. alpha-naphthoflavone 31-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-101 30971064-7 2019 Activation of the AhR-target gene CYP1A1 by PM was reduced by co-treatment with alpha-naphthoflavone (alpha-NF), an AhR inhibitor. alpha-naphthoflavone 80-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 30971064-7 2019 Activation of the AhR-target gene CYP1A1 by PM was reduced by co-treatment with alpha-naphthoflavone (alpha-NF), an AhR inhibitor. alpha-naphthoflavone 102-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 28834568-7 2018 The aryl hydrocarbon receptor antagonist/CYP1A1 inhibitor alpha-naphthoflavone decreased luciferase induction and EROD activity by several compounds, including the methylated chrysenes, suggesting that metabolites of these chemicals contributed to ER activation. alpha-naphthoflavone 58-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 30010034-9 2018 Diuron metabolism was inhibited upon addition of alpha-naphthoflavone, a CYP1A1 inhibitor, underscoring the role of CYP1A1 in the metabolism. alpha-naphthoflavone 49-69 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 30010034-9 2018 Diuron metabolism was inhibited upon addition of alpha-naphthoflavone, a CYP1A1 inhibitor, underscoring the role of CYP1A1 in the metabolism. alpha-naphthoflavone 49-69 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 116-122 29332599-8 2018 Experiments using the CYP1 inhibitors acacetin and alpha-naphthoflavone provided supporting evidence for the involvement of CYP1 enzymes in the bioactivation of these compounds. alpha-naphthoflavone 51-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-26 29332599-8 2018 Experiments using the CYP1 inhibitors acacetin and alpha-naphthoflavone provided supporting evidence for the involvement of CYP1 enzymes in the bioactivation of these compounds. alpha-naphthoflavone 51-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 124-128 23452206-8 2013 CSC-induced NF-kappaB activation, IL-1beta promoter activity, IL-1beta mRNA upregulation, and CYP1A1 mRNA induction were all inhibited by an aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone. alpha-naphthoflavone 184-204 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 28103884-9 2017 Activation of AhR/CYP1A1 in MCF-7 cells by TCDD and DMBA, strong AhR activators, significantly increased CSC-specific markers, mammosphere formation, aldehyde dehydrogenase (ALDH) activity, and percentage of side population (SP) cells, whereas inactivation of AhR/CYP1A1 using chemical inhibitor, alpha-naphthoflavone (alpha-NF), or by genetic shRNA knockdown, significantly inhibited the upregulation of ALDH activity and SP cells. alpha-naphthoflavone 297-317 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-24 27113703-5 2016 The CYP3A4 inhibitor ketoconazole and the CYP1A1 inhibitor alpha-naphthoflavone drastically inhibited the metabolism of amiodarone to desethylamiodarone. alpha-naphthoflavone 59-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 23508959-4 2013 We determined a 2.6 A structure of human CYP1A1 with the inhibitor alpha-naphthoflavone. alpha-naphthoflavone 67-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 21244437-4 2011 The other two human CYP inhibitors were classified as strong inhibitors of CYP2A: 8-methoxypsoralen (CYP2A6) and alpha-naphthoflavone (CYP1A1/2). alpha-naphthoflavone 113-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 22749133-8 2013 More importantly, induction of G2/M arrest and p53 and p-ERK up-regulation were reversed by the application of the CYP1 inhibitor alpha-naphthoflavone. alpha-naphthoflavone 130-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 115-119 23033491-6 2013 Chemosensitivity to ICT2700 was also negated in EJ138-CYP1A1 cells by the CYP1 inhibitor alpha-naphthoflavone. alpha-naphthoflavone 89-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 23033491-6 2013 Chemosensitivity to ICT2700 was also negated in EJ138-CYP1A1 cells by the CYP1 inhibitor alpha-naphthoflavone. alpha-naphthoflavone 89-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-58 22837390-7 2012 The combined effect of 1,25(OH)(2)D(3) and BaP on CYP1A1 mRNA expression in U937 cells and/or THP-1 cells was inhibited by VDR knockdown, VDR antagonists, and alpha-naphthoflavone, an AHR antagonist. alpha-naphthoflavone 159-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 21726170-10 2011 Similarly, alpha-naphthoflavone (CYP1A1 inhibitor) and furafylline (CYP1A2 inhibitor) significantly decreased the formation of 4"-OH-NBL. alpha-naphthoflavone 11-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 19789301-10 2009 Pretreatment with alpha-naphthoflavone or 17-AAG blocked FICZ-mediated induction of CYP1A1 and CYP1B1, and suppressed the increased B[a]P-induced DNA adduct formation. alpha-naphthoflavone 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 21127131-3 2011 The partial AHR agonist alpha-naphthoflavone (alphaNF) mediates the suppressive, non-DRE dependent effects on SAA1 expression and partial DRE-mediated CYP1A1 induction. alpha-naphthoflavone 24-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-157 21162728-10 2010 A CYP1A1 inhibitor (alpha-naphthoflavone), nearly abolished the DEP-induced expression of IL-8 and COX-2. alpha-naphthoflavone 20-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 2-8 20550209-5 2010 An assay using recombinant human CYP1A1 and the CYP1A1 inhibitor alpha-naphthoflavone revealed that CYP1A1 oxidized galangin to kaempferol. alpha-naphthoflavone 65-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 20550209-5 2010 An assay using recombinant human CYP1A1 and the CYP1A1 inhibitor alpha-naphthoflavone revealed that CYP1A1 oxidized galangin to kaempferol. alpha-naphthoflavone 65-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 20187624-9 2010 Treatment with 3MI in combination with the AhR antagonist alpha-naphthoflavone prevented 3MI-mediated CYP1A1 induction, indicating that the induction was AhR-dependent. alpha-naphthoflavone 58-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 20435083-3 2010 All three activities were substantially inhibited (>or=75%) by the CYP1 inhibitor alpha-naphthoflavone, whereas only MROD and CECOD were substantially inhibited by the CYP1A2-preferential inhibitor fluvoxamine. alpha-naphthoflavone 85-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-74 19386251-10 2009 alpha-Naphthoflavone (ANF), an inhibitor of CYP1A1, inhibited MN formation in the presence of both BaP and PCB153. alpha-naphthoflavone 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 19386251-10 2009 alpha-Naphthoflavone (ANF), an inhibitor of CYP1A1, inhibited MN formation in the presence of both BaP and PCB153. alpha-naphthoflavone 22-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 19553035-8 2009 The synergistic effect of PCB126 on BaP-induced MN formation was inhibited by alpha-naphthoflavone (ANF), an inhibitor of CYP1A1. alpha-naphthoflavone 78-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128 19553035-8 2009 The synergistic effect of PCB126 on BaP-induced MN formation was inhibited by alpha-naphthoflavone (ANF), an inhibitor of CYP1A1. alpha-naphthoflavone 100-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128