PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3104258-7	1987	From these results, it was suggested that high-spin forms of cytochrome P-450 (MC-P-448-H and P-448 ham-II) played an important role in the metabolic activation of phenacetin to the direct-acting mutagens.	Phenacetin	164-174	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	61-77	
15231049-2	2004	Using rat cDNA-expressed cytochrome P450 (CYP) enzymes, we found that phenacetin biotransformation was primarily mediated by CYP2C6 and CYP1A isoforms, while chlorzoxazone biotransformation was largely mediated by CYP2E1 and CYP1A1.	Phenacetin	70-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-40	
15231049-2	2004	Using rat cDNA-expressed cytochrome P450 (CYP) enzymes, we found that phenacetin biotransformation was primarily mediated by CYP2C6 and CYP1A isoforms, while chlorzoxazone biotransformation was largely mediated by CYP2E1 and CYP1A1.	Phenacetin	70-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-45	
3104258-0	1987	Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters.	Phenacetin	24-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	71-87	
3104258-2	1987	Five different molecular species of cytochrome P-450 have been purified from liver microsomes of drug-pretreated Wistar rats or Syrian hamsters and their abilities to activate phenetidine and phenacetin were compared using reconstituted microsome systems.	Phenacetin	192-202	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52	
3729972-3	1986	Microsomal monooxygenase heterogeneity is also shown to provide a plausible explanation of other published results signifying the departure of chloramphenicol and phenacetin from the concept of competitive inhibition despite competition with substrate for the active-site haem group of cytochrome P-450.	Phenacetin	163-173	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	286-302	
30219678-12	2018	The metabolic capacity of CYP450 was evaluated using five probe drugs, phenacetin, tolbutamide, metoprolol, midazolam, and bupropion.	Phenacetin	71-81	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	26-32	
23444776-3	2013	Phenacetin, coumarin, tolbutamide, chlorzoxazone and testosterone are commonly used as probe substrates to evaluate cytochrome P450 function.	Phenacetin	0-10	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	116-131