PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8474022-7	1993	In contrast, the monoclonal antibody MAb 1-7-1, raised against 3-methylcholanthrene-inducible rat cytochromes 450, almost abolished CYP1A1-mediated phenacetin O-deethylation, but had no effect on human liver microsomal- or CYP1A2-catalyzed phenacetin dealkylation.	Phenacetin	148-158	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	132-138	
15231049-2	2004	Using rat cDNA-expressed cytochrome P450 (CYP) enzymes, we found that phenacetin biotransformation was primarily mediated by CYP2C6 and CYP1A isoforms, while chlorzoxazone biotransformation was largely mediated by CYP2E1 and CYP1A1.	Phenacetin	70-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	225-231	
2306261-4	1990	Studies with the reconstituted enzymes have shown that both forms of P450 catalyse phenacetin O-deethylation at rates that exceeded that of the high affinity component of activity of hepatic microsomal preparations from 3-methylcholanthrene-treated rats (at 4 microM phenacetin: P450c, 440 +/- 40 pmol/nmol/min; P450d, 1030 +/- 10 pmol/nmol/min; microsomal fraction, 163 pmol/mg/min).	Phenacetin	83-93	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	279-284	
3729972-3	1986	Microsomal monooxygenase heterogeneity is also shown to provide a plausible explanation of other published results signifying the departure of chloramphenicol and phenacetin from the concept of competitive inhibition despite competition with substrate for the active-site haem group of cytochrome P-450.	Phenacetin	163-173	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-24	
11765139-2	2001	The inhibition of recombinant CYP1A1 and CYP1A2 activity by quinidine and quinine was evluated using ethoxyresorutin O-deethylation, phenacetin O-deethylation and propranolol desisopropylation as probe catalytic pathways.	Phenacetin	133-143	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	30-36