PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Polycyclic Aromatic Hydrocarbons 111-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-57 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Polycyclic Aromatic Hydrocarbons 111-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-32 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 176-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-32 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 176-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 19202560-1 2009 CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. Polycyclic Aromatic Hydrocarbons 37-69 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 20700368-2 2010 Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 5-23 20700368-2 2010 Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 19365803-4 2010 For the targeted ClPAHs, Western blot analysis of ClPAH-induced CYP1A1 and 1B1 showed an enhancement in activities in comparison with induction by the corresponding parent PAHs, and the effects of chlorination were especially prominent in phenanthrene. Polycyclic Aromatic Hydrocarbons 19-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-78 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. Polycyclic Aromatic Hydrocarbons 310-313 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. Polycyclic Aromatic Hydrocarbons 310-313 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 19608585-2 2010 Phase I enzymes, including cytochrome P(450), family 1, subfamily A, polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive intermediates that are capable of binding covalently to DNA to form DNA adducts, potentially initiating the carcinogenic process. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-82 19608585-2 2010 Phase I enzymes, including cytochrome P(450), family 1, subfamily A, polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive intermediates that are capable of binding covalently to DNA to form DNA adducts, potentially initiating the carcinogenic process. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 19789301-2 2009 UVR-mediated activation of the aryl hydrocarbon receptor (AhR) stimulates the transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAH to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 149-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 44-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 78-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 78-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 172-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-5 2009 Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells. Polycyclic Aromatic Hydrocarbons 48-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 19538838-9 2009 Genetic polymorphism of CYP1A1 gene could be a susceptible biomarker in coke oven workers which was involved in the individual susceptibility on metabolism of PAHs. Polycyclic Aromatic Hydrocarbons 159-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 18952161-3 2009 In human AM in mono- and coculture, and in L132 cells in monoculture, VOC and/or PAH-coated onto PM induced the gene expression of CYP1A1, CYP2E1, NQO1, GST-pi1, and/or GST-mu3. Polycyclic Aromatic Hydrocarbons 81-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 131-137 19362136-0 2009 The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells. Polycyclic Aromatic Hydrocarbons 73-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 19362136-1 2009 Polycyclic aromatic hydrocarbons (PAHs)--environmental carcinogens--are metabolized by CYP1A1 and CYP1A2 enzymes to oxy-derivatives, which are able to bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 19362136-1 2009 Polycyclic aromatic hydrocarbons (PAHs)--environmental carcinogens--are metabolized by CYP1A1 and CYP1A2 enzymes to oxy-derivatives, which are able to bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 19362136-2 2009 PAHs induce CYP1A1 and CYP1A2 activity, which increases the risk of development of carcinogenesis. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 19362136-4 2009 In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7. Polycyclic Aromatic Hydrocarbons 189-193 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 19346634-1 2009 BACKGROUND: The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. Polycyclic Aromatic Hydrocarbons 130-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-35 19346634-1 2009 BACKGROUND: The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. Polycyclic Aromatic Hydrocarbons 130-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 19202560-1 2009 CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. Polycyclic Aromatic Hydrocarbons 71-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17981384-5 2007 In the current study, cytochrome P450 (CYP) 1A1 and UDP-glucuronosyltransferase (UGT) 1A1 were over-expressed in the breast cancer MCF-7 cells, and potential interactions between these enzymes and estrogen or polycyclic aromatic hydrocarbon were evaluated. Polycyclic Aromatic Hydrocarbons 209-240 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-47 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 106-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 106-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 19317600-1 2008 Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-14 19317600-1 2008 Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 18797853-4 2008 Our studies were carried out with metabolically competent primary porcine urinary bladder epithelial cells (PUBECs) and the human urothelial cell line 5637 for which we have previously demonstrated CYP1A1 mRNA induction by the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) applying real-time RT-PCR. Polycyclic Aromatic Hydrocarbons 227-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-204 18797853-4 2008 Our studies were carried out with metabolically competent primary porcine urinary bladder epithelial cells (PUBECs) and the human urothelial cell line 5637 for which we have previously demonstrated CYP1A1 mRNA induction by the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) applying real-time RT-PCR. Polycyclic Aromatic Hydrocarbons 260-264 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-204 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 27-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 143-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 19138996-3 2008 The main objectives of this study were to determine whether HSP90 inhibitors suppress PAH-mediated induction of CYP1A1 and CYP1B1 or block benzo(a)pyrene [B(a)P]-induced formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 112-118 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 18178302-5 2008 Moreover, VOC and/or PAH coated onto PM induced gene expression of cytochrome P450 (cyp) 1a1, cyp2e1, nadph quinone oxydo-reductase-1, and glutathione S-transferase-pi 1 and mu 3, versus controls, suggesting thereby the formation of biologically reactive metabolites. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-92 17874067-2 2008 CYP1A1 induction has been widely studied in mammal cell cultures or in vivo, in conditions of exposure to single PAH chemicals. Polycyclic Aromatic Hydrocarbons 113-116 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Polycyclic Aromatic Hydrocarbons 140-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 53-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 142-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 213-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 142-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17884947-11 2007 Together, these results indicate that the deficiency of CYP1A1 activity might be a decisive condition rendering Leydig cells secure from exogenous polycyclic aromatic hydrocarbons such as B[a]P. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 17462623-9 2007 The VOC and/or PAH-coated onto PM induced significant increases in mRNA expressions of cytochrome P450 (cyp) 1a1, cyp2e1, cyp2f1, nadph quinone oxydo-reductase-1, and glutathione s-transferase-pi 1, versus controls. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-112 17560011-4 2007 The formation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts and the expression of PAH-metabolizing enzymes cytochrome P450 (CYP) 1A1 and arylhydrocarbon receptor (AhR) were detected by Western blot and/or quantitative RT-PCR. Polycyclic Aromatic Hydrocarbons 89-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-139 17707923-1 2007 Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene. Polycyclic Aromatic Hydrocarbons 27-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 200-206 17560072-3 2007 CYP1A1 is a major enzyme that metabolizes PAH into carcinogenic moieties. Polycyclic Aromatic Hydrocarbons 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17630984-1 2007 CYP1A1, a cytochrome P450 enzyme, metabolizes polycyclic aromatic hydrocarbons to genotoxic metabolite(s) that bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17431034-1 2007 CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. Polycyclic Aromatic Hydrocarbons 79-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-14 17431034-1 2007 CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. Polycyclic Aromatic Hydrocarbons 113-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-14 17431034-2 2007 CYP1As are highly inducible by PAHs and halogenated aromatic hydrocarbons via aryl hydrocarbon receptor-mediated gene transcription. Polycyclic Aromatic Hydrocarbons 31-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 17440990-1 2007 CYP1A1 and CYP1B1 are the inducible forms of cytochrome P450 expressed in extrahepatic tissues, which are responsible for the biotransformation of polycyclic aromatic hydrocarbons, heterocyclic amines and estradiol to the carcinogenic intermediates. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16485905-0 2006 Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 122-154 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-39 17187366-0 2007 Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar. Polycyclic Aromatic Hydrocarbons 111-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 17060372-0 2007 Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 17060372-7 2007 Induction of cytochrome P450 (CYP)1A1 and 1B1 proteins was also detected following UDPM treatment or cotreatment with B[a]P or DB[a,l]P, indicating PAH bioactivation. Polycyclic Aromatic Hydrocarbons 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-45 17158763-2 2006 Cytochrome P4501A1 (CYP1A1) gene variants may be related to an increased capacity to activate polycyclic aromatic hydrocarbons, producing highly reactive electrophilic intermediates that might damage DNA. Polycyclic Aromatic Hydrocarbons 94-126 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 17158763-2 2006 Cytochrome P4501A1 (CYP1A1) gene variants may be related to an increased capacity to activate polycyclic aromatic hydrocarbons, producing highly reactive electrophilic intermediates that might damage DNA. Polycyclic Aromatic Hydrocarbons 94-126 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 16416283-1 2006 PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Polycyclic Aromatic Hydrocarbons 9-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-78 16416283-1 2006 PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Polycyclic Aromatic Hydrocarbons 9-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 16611024-1 2006 Cytochrome P450 (CYP) 1A1 attracts attention mainly because of its role in production of carcinogenic reactive metabolites from polycyclic aromatic hydrocarbons such as benzo[a]pyrene, but recent developments indicate its apparent role in cell cycle progression. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 16581943-1 2006 CYP1A1, a major phase I enzyme, plays an important role in the metabolism of polycyclic aromatic hydrocarbons and in the chemical activation of xenobiotics to carcinogenic derivatives. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16472762-0 2006 CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16137816-1 2005 CYP1A1 is an extrahepatic enzyme largely involved in the bioactivation of various procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. Polycyclic Aromatic Hydrocarbons 105-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17017525-5 2006 CYP1A1 bioactivates polycyclic aromatic hydrocarbons to reactive DNA binding metabolites and initiates carcinogenesis. Polycyclic Aromatic Hydrocarbons 20-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16137816-1 2005 CYP1A1 is an extrahepatic enzyme largely involved in the bioactivation of various procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. Polycyclic Aromatic Hydrocarbons 139-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16284498-9 2005 This study suggests that maternal smoking may be a risk factor for leukaemia in children who carry CYP1A1 or GSTM1 genotypes, which might increase reactive metabolites of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 171-203 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 16153604-5 2005 Thus, the Ile462Val polymorphism in human CYP1A1 affects EPA metabolism and may contribute to interindividual variance in the local production of physiologically active fatty acid metabolites in the cardiovascular system and other extrahepatic tissues, where CYP1A1 is expressed or induced by polycyclic aromatic hydrocarbons and other xenobiotics. Polycyclic Aromatic Hydrocarbons 293-325 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 16202979-0 2005 CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 57-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16202979-4 2005 Thus, the aim of this study was to clarify the role of CYP1A1 in the suppression of LXR-mediated signal transductions by 3-methlychoranthrene (MC), one of the PAHs. Polycyclic Aromatic Hydrocarbons 159-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 16202979-7 2005 Based on these lines of evidence, we propose that the metabolic activation of PAHs by CYP1A1, but not the activation of AHR by PAHs, is a direct mechanism for atherosclerosis via the suppression of LXR-mediated signal transductions. Polycyclic Aromatic Hydrocarbons 78-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 16153604-5 2005 Thus, the Ile462Val polymorphism in human CYP1A1 affects EPA metabolism and may contribute to interindividual variance in the local production of physiologically active fatty acid metabolites in the cardiovascular system and other extrahepatic tissues, where CYP1A1 is expressed or induced by polycyclic aromatic hydrocarbons and other xenobiotics. Polycyclic Aromatic Hydrocarbons 293-325 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 259-265 16393856-1 2005 2"-Amino-3"-methoxyflavone (PD98059), an MKK1 inhibitor, negatively regulates the induction of the CYP1A1 gene by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 114-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 15953982-1 2005 OBJECTIVE: We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women. Polycyclic Aromatic Hydrocarbons 106-138 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 15947024-1 2005 Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 15947024-1 2005 Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 15870154-1 2005 Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic aromatic hydrocarbons and in estrogen metabolism. Polycyclic Aromatic Hydrocarbons 69-101 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-26 15953982-1 2005 OBJECTIVE: We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women. Polycyclic Aromatic Hydrocarbons 140-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 15521013-1 2004 BACKGROUND AND AIMS: Cytochrome P450 1A1 catalyzes the degradation of endobiotics (estradiol, fatty acids, and so on) and the bioactivation of numerous environmental procarcinogens, such as arylamines and polycyclic aromatic hydrocarbons, that are found in food. Polycyclic Aromatic Hydrocarbons 205-237 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-40 15836631-2 2005 CYP1A1, a cytochrome P-450 enzyme, bioactivates polycyclic aromatic hydrocarbons to reactive metabolite(s) that bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 48-80 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16101325-2 2005 Major polycyclic aromatic hydrocarbons (PAHs) included in the extracts of airborne particles were investigated for their mutagenicity and potential for inducing drug-metabolizing enzyme cytochrome P450 (CYP)1A1, which is considered to be responsible for the activation of PAHs in airborne particle extracts, as well as in cigarette smoke, to carcinogens and is associated with risk of several cancers. Polycyclic Aromatic Hydrocarbons 6-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-210 16101325-2 2005 Major polycyclic aromatic hydrocarbons (PAHs) included in the extracts of airborne particles were investigated for their mutagenicity and potential for inducing drug-metabolizing enzyme cytochrome P450 (CYP)1A1, which is considered to be responsible for the activation of PAHs in airborne particle extracts, as well as in cigarette smoke, to carcinogens and is associated with risk of several cancers. Polycyclic Aromatic Hydrocarbons 40-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-210 16101325-2 2005 Major polycyclic aromatic hydrocarbons (PAHs) included in the extracts of airborne particles were investigated for their mutagenicity and potential for inducing drug-metabolizing enzyme cytochrome P450 (CYP)1A1, which is considered to be responsible for the activation of PAHs in airborne particle extracts, as well as in cigarette smoke, to carcinogens and is associated with risk of several cancers. Polycyclic Aromatic Hydrocarbons 272-276 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-210 16101325-3 2005 There was a dose-related increase in CYP1A1 activity in human lymphoblastoid cells after exposure to airborne particulates containing PAHs. Polycyclic Aromatic Hydrocarbons 134-138 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 144-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 15801491-10 2004 This finding is consistent with previous studies suggesting that substrates for the cytochrome P-450 1A1 metabolic pathway, such as polycyclic aromatic hydrocarbons, may be etiologically significant in this high-risk region. Polycyclic Aromatic Hydrocarbons 132-164 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-104 15566942-8 2004 The mixture of PAH also induced CYP1A1, CYP1B1, UGT1A6, and UGT1A7 mRNA expression. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 177-181 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 15671210-1 2005 We hypothesized that the risk of colorectal cancer associated with meat preparation methods producing heterocyclic amines or polycyclic aromatic hydrocarbons is modified by the CYP1A1 genotype alone or in combination with the GSTM1 genotype or the NAT2 imputed phenotype. Polycyclic Aromatic Hydrocarbons 125-157 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 177-183 15581594-4 2005 However, induction of Cyp1a1 is known to represent a significant event in the toxicity of PAHs. Polycyclic Aromatic Hydrocarbons 90-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 124-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 158-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15464628-4 2004 Organic pollutants influence the expression profile of cytochromes P450 (CYP), and CYP1A1 has been shown to be a suitable biomarker for polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 136-168 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 15464628-4 2004 Organic pollutants influence the expression profile of cytochromes P450 (CYP), and CYP1A1 has been shown to be a suitable biomarker for polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 170-173 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 15471096-1 2004 Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n = 30) occupationally exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 165-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 15584438-7 2004 Almost all studies show the clearcut influence (i.e., increased lung cancer risk with OR > or = 2) of genetic polymorphisms linked to PAH metabolism (in particular, CYPIA1, GSTM1 and P1). Polycyclic Aromatic Hydrocarbons 137-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 168-174 15471096-1 2004 Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n = 30) occupationally exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 199-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 15742974-0 2004 Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. Polycyclic Aromatic Hydrocarbons 42-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 15742974-0 2004 Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. Polycyclic Aromatic Hydrocarbons 171-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 188-220 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15028720-2 2004 The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products. Polycyclic Aromatic Hydrocarbons 92-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15028720-2 2004 The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products. Polycyclic Aromatic Hydrocarbons 126-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 222-226 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 353-357 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-6 2004 The present data suggest that amiloride derivatives, such as EIPA, may be useful for preventing toxicity of chemical carcinogens, such as PAHs, through inhibition of CYP1 enzyme activity. Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 166-170 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 124-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15041462-11 2004 It is suggested that the capacity of human CYP1A1 to metabolize AA and EPA and its inducibility by polycyclic aromatic hydrocarbons may affect the production of physiologically active metabolites, in particular, in the cardiovascular system and other extrahepatic tissues including lung. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 158-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 12930004-3 2003 PAHs have been well established as an enzyme inducer of cytochrome P450 (CYP) such as CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 133-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 294-326 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-170 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 294-326 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 328-332 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-170 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 328-332 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 15176217-6 2004 The CYP1A1 allele incidence (19%) in patients with squamous lung cancer was significantly higher than in the control cohorts (11%) which is consistent with the leading role of PAH in the etiology of this pathology. Polycyclic Aromatic Hydrocarbons 176-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 14695173-1 2003 Cytochrome P4501A1 (CYP1A1), which is involved in the metabolic activation of polycyclic aromatic hydrocarbon procarcinogens derived from tobacco smoke, is induced in the lung up to 100-fold because of tobacco smoking. Polycyclic Aromatic Hydrocarbons 78-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 12531201-0 2003 Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. Polycyclic Aromatic Hydrocarbons 39-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-30 12468438-10 2003 The CYP1A1*2B allele may predispose to the development of these subgroups of AML by augmented phase 1 metabolism to highly reactive intermediates of CYP1A1 substrates, including polycyclic aromatic hydrocarbons, or by generation of oxidative stress as a metabolic by-product. Polycyclic Aromatic Hydrocarbons 178-210 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 103-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 103-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 137-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 137-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 12490585-0 2003 Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 131-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 176-207 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 11469723-2 2001 The CYP1A1 gene encodes microsomal cytochrome P4501A1 that catalyzes the metabolism of many xenobiotics, including the oxygenation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 134-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 12237110-2 2002 Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. Polycyclic Aromatic Hydrocarbons 45-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 12237110-2 2002 Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. Polycyclic Aromatic Hydrocarbons 79-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 12237110-7 2002 FBS potentiation of CYP1A1 PAH-mediated induction was related to a significant increase of single strand breaks of DNA as compared to a single 3-MC treatment. Polycyclic Aromatic Hydrocarbons 27-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 11948486-5 2002 PAHs are metabolically activated by phase I enzymes, including CYP1A1, into electrophilic reactants (diol epoxides), which covalently bind to DNA to form adducts. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 11675150-10 2001 Taken together, these findings suggest that Chilean people carrying single or combined GSTM1 and CYP1A1 polymorphisms could be more susceptible to lung cancer induced by environmental pollutants such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 203-235 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-103 12378791-1 2002 Several ethnic groups have been genotyped for polymorphisms at the CYP1A1 gene locus that encodes the enzyme that catalyzes the initial step in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 162-194 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 12224597-8 2002 Since CYP1A1/1B1 were responsible for the biotransformation of polycyclic aromatic hydrocarbons, baicalein also demonstrated its ability to reduce DMBA-DNA adduct formation in MCF-7 cells. Polycyclic Aromatic Hydrocarbons 63-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-16 12107650-0 2002 Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 111-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-32 12107650-0 2002 Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 145-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-32 12107650-2 2002 The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 in various organs have been analyzed. Polycyclic Aromatic Hydrocarbons 58-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 153-159 12107650-2 2002 The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 in various organs have been analyzed. Polycyclic Aromatic Hydrocarbons 92-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 153-159 12107650-8 2002 As is shown in one case, impairment of CYP1A1 induction in the liver and thus breakdown of its PAH-metabolizing activity appears to have no effect on induced CYP1A1 levels in other organs. Polycyclic Aromatic Hydrocarbons 95-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 12034316-1 2002 The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation. Polycyclic Aromatic Hydrocarbons 161-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 235-241 11952781-2 2002 Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-24 11952781-2 2002 Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 11689007-6 2001 It is possible that the abrogation of CYP1A1 induction in the combined Lys(554) + Ile(570) variant may reduce susceptibility of the host to the carcinogenic effects of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 168-200 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-44 11600727-13 2001 The variant genotypes of the CYP1A1 gene may result in the enhancement of PAH metabolites. Polycyclic Aromatic Hydrocarbons 74-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 11694458-7 2001 We demonstrate, for the first time, in airway epithelial cells in vitro that nDEP induce the expression of the CYP1A1, a cytochrome P450 specifically involved in polycyclic aromatic hydrocarbons metabolism, thereby demonstrating the critical role of organic compounds in the DEP-induced proinflammatory response. Polycyclic Aromatic Hydrocarbons 162-194 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 11694458-9 2001 In conclusion, the DEP-induced inflammatory response in airway epithelial cells mainly involves organic compounds such as PAH, which induce CYP1A1 gene expression. Polycyclic Aromatic Hydrocarbons 122-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 11535067-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by human epoxide hydrolase (EH) and CYP1A1. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 11535067-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by human epoxide hydrolase (EH) and CYP1A1. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 11408366-0 2001 Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 11469723-2 2001 The CYP1A1 gene encodes microsomal cytochrome P4501A1 that catalyzes the metabolism of many xenobiotics, including the oxygenation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 168-171 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 11469723-3 2001 Induction of CYP1A1 enhances the metabolism of PAHs, and therefore, represents an adaptive response to chemical exposure in mammalian cells. Polycyclic Aromatic Hydrocarbons 47-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 11469723-7 2001 Thus, mechanistic studies of CYP1A1 induction have provided insights into P450 induction, PAH carcinogenesis, dioxin action, AhR function, and receptor-mediated mammalian gene expression. Polycyclic Aromatic Hydrocarbons 90-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 11468695-3 2001 The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C-->T:A point mutations. Polycyclic Aromatic Hydrocarbons 82-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 11306097-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by CYP1A1 and epoxide hydrolase (EH). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 11507974-8 2001 Thus the prevalence of two polymorphic genes CYP1A1 and GSTM1 responsible for the biotransformation of polycyclic aromatic hydrocarbons was too high in the non-healthy group. Polycyclic Aromatic Hydrocarbons 103-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 11306097-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by CYP1A1 and epoxide hydrolase (EH). Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 11306097-8 2001 The high catalytic efficiency of AKR1A1 for potent proximate carcinogen trans-dihydrodiols and its presence in tissues that contain CYP1A1 and EH suggests that it plays an important role in this alternative pathway of PAH activation (supported by CA39504). Polycyclic Aromatic Hydrocarbons 218-221 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-138 11524025-4 2001 PAHs have been shown to induce 3 hepatic cytochrome P450 (CYP) isozymes, primarily CYP1A1, 1A2 and 2E1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 11162773-0 2001 Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Polycyclic Aromatic Hydrocarbons 20-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 11162773-7 2001 All four metals (1-5 microM) decreased CYP1A1/1A2 induction by some of the PAHs with dose-, metal-, and PAH-dependency. Polycyclic Aromatic Hydrocarbons 75-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 11162773-7 2001 All four metals (1-5 microM) decreased CYP1A1/1A2 induction by some of the PAHs with dose-, metal-, and PAH-dependency. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 11162773-10 2001 Thus the metals in PAH/metal mixtures could diminish PAH carcinogenicity by decreasing induction of their bioactivation by CYP1A1/1A2. Polycyclic Aromatic Hydrocarbons 19-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 11162773-10 2001 Thus the metals in PAH/metal mixtures could diminish PAH carcinogenicity by decreasing induction of their bioactivation by CYP1A1/1A2. Polycyclic Aromatic Hydrocarbons 53-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 23889309-0 2001 Benzo(a)pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes. Polycyclic Aromatic Hydrocarbons 68-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 11037803-4 2000 The activation phase of polycyclic aromatic hydrocarbon (PAH) metabolism is governed by the enzyme CYP1A1, induced by PAH when it enters the body. Polycyclic Aromatic Hydrocarbons 24-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 11113705-0 2000 Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Polycyclic Aromatic Hydrocarbons 75-106 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 162-187 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 237-269 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-22 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 237-269 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 271-275 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-22 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 271-275 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 11037803-4 2000 The activation phase of polycyclic aromatic hydrocarbon (PAH) metabolism is governed by the enzyme CYP1A1, induced by PAH when it enters the body. Polycyclic Aromatic Hydrocarbons 57-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 11037803-4 2000 The activation phase of polycyclic aromatic hydrocarbon (PAH) metabolism is governed by the enzyme CYP1A1, induced by PAH when it enters the body. Polycyclic Aromatic Hydrocarbons 118-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 11037803-5 2000 The extent to which PAH induces CYP1A1 activity varies greatly from one subject to another. Polycyclic Aromatic Hydrocarbons 20-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 16-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 213-219 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 186-189 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 194-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 10753202-0 2000 CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 11465078-3 2000 For example, Cyp 1A1 is particularly active towards polycyclic aromatic hydrocarbons (PAHs), activating them into reactive intermediates those covalently bind to DNA, a key event in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-20 11465078-3 2000 For example, Cyp 1A1 is particularly active towards polycyclic aromatic hydrocarbons (PAHs), activating them into reactive intermediates those covalently bind to DNA, a key event in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 86-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-20 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 50-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 213-219 10698483-0 2000 Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Polycyclic Aromatic Hydrocarbons 20-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-155 10575002-8 1999 These data demonstrate that DHEA inhibits PAH-induced CYP1A1 mRNA expression and enzyme activity in vitro by a post-transcriptional mechanism. Polycyclic Aromatic Hydrocarbons 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 10575002-3 1999 DHEA inhibited the increase in CYP1A1 enzyme activity that occurs when MCF-7 cells are exposed to the PAH dimethylbenzanthracene (DMBA) or 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 102-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 10651994-8 2000 Ultraviolet-B induction of both cytochrome P450 1A1 and cytochrome P450 1B1 in human skin will probably result in enhanced bioactivation of polycyclic aromatic hydrocarbons and other environmental pollutants to which humans are exposed, which in turn could make the human skin more susceptible to ultraviolet-B-induced skin cancers or allergic and irritant contact dermatitis. Polycyclic Aromatic Hydrocarbons 140-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-51 10631103-1 2000 CYP1A1 is implicated in the bioactivation of procarcinogens such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 68-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 11996099-1 2000 In contrast to the well-known Ah receptor-mediated regulation of the CYP1A1 gene by polycyclic aromatic hydrocarbons, the molecular mechanism by which phenobarbital (PB) and PB-like inducers affect transcription of CYP genes remains unknown; no receptor for these chemicals has been found to date. Polycyclic Aromatic Hydrocarbons 84-116 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 69-75 10427467-5 1999 Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 157-163 10443949-5 1999 Other links between meat, cooking methods, metabolic genotypes and risk for cancer might include enhanced activation of polycyclic aromatic hydrocarbons and N-nitroso compounds by variant genotypes of CYP1A1 and CYP2E1, respectively, and modulation by meat of the protective effect of the E4 allele of apolipoprotein E on risk for cancer of the proximal colon. Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 201-207 10408872-2 1999 Cytochrome P450 1A1 (CYP1A1) is involved in the biotransformation of tobacco-derived polycyclic aromatic hydrocarbons (PAHs) into carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 85-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 10408872-2 1999 Cytochrome P450 1A1 (CYP1A1) is involved in the biotransformation of tobacco-derived polycyclic aromatic hydrocarbons (PAHs) into carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 119-123 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 9744530-1 1998 Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-174 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-179 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 232-238 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 117-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-174 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 117-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-179 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 117-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 232-238 10331078-1 1999 Cytochrome P4501A1 is a substrate-inducible microsomal enzyme that oxygenates polycyclic aromatic hydrocarbons, such as the carcinogen benzo(a)pyrene, as the initial step in their metabolic processing to water-soluble derivatives. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-83 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-91 9752993-3 1998 Epidemiological studies have shown that P4501A1 (CYP1A1) genotypes are associated with PAH-related lung cancer risk. Polycyclic Aromatic Hydrocarbons 87-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 9744530-1 1998 Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 9744534-0 1998 Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 9639391-1 1998 Cytochrome P4501A1 (CYP1A1) is involved in the bioactivation of polycyclic aromatic hydrocarbons into their reactive epoxide metabolites. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 9639391-1 1998 Cytochrome P4501A1 (CYP1A1) is involved in the bioactivation of polycyclic aromatic hydrocarbons into their reactive epoxide metabolites. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 9538942-1 1998 The induction of cytochrome P4501A (CYP1A1) enzyme activity is one of the best-studied direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds and has been shown to be a sensitive biomarker of exposure to polycyclic aromatic hydrocarbons (PAH) in different experimental animal species as well as in humans. Polycyclic Aromatic Hydrocarbons 232-264 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 9622076-13 1998 This study indicates that CYP1B1 is an important activator of polycyclic aromatic hydrocarbons in the mammary gland when environmental chemical exposures minimally induce CYP1A1. Polycyclic Aromatic Hydrocarbons 62-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 171-177 9622076-14 1998 Additionally, certain individuals express low levels of basal CYP1A1 in HMECs, representing a potential risk factor of mammary carcinogenesis through enhanced polycyclic aromatic hydrocarbon bioactivation. Polycyclic Aromatic Hydrocarbons 159-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 9488590-11 1998 These findings are suggestive of a gene-environment interaction, in which subjects with the CYP1A1 polymorphism, relative to subjects without it, have higher levels of 1-OH-P in their urine at low doses of exposure to PAHs. Polycyclic Aromatic Hydrocarbons 218-222 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 92-98 9538942-1 1998 The induction of cytochrome P4501A (CYP1A1) enzyme activity is one of the best-studied direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds and has been shown to be a sensitive biomarker of exposure to polycyclic aromatic hydrocarbons (PAH) in different experimental animal species as well as in humans. Polycyclic Aromatic Hydrocarbons 266-269 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 10026994-9 1998 Further genetic analyses confirmed that the combination of CYP1A1 homozygous mutants and GSTM1 inactive leads to high levels of BPDE-DNA adducts in human lung of smokers and white blood cells of PAH-exposed coke oven workers. Polycyclic Aromatic Hydrocarbons 195-198 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 8824276-1 1996 Transcriptional activation of the human CYP1A1 gene by halogenated and polycyclic aromatic hydrocarbons is mediated by the aryl hydrocarbon receptor (AhR) complex, a ligand-dependent transcription factor. Polycyclic Aromatic Hydrocarbons 71-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 8954573-0 1996 Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study. Polycyclic Aromatic Hydrocarbons 15-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-78 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 93-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-55 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-55 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 193-199 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 193-199 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-51 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 292-298 8666157-1 1996 The induction of microsomal cytochrome P4501A1 by polycyclic aromatic hydrocarbons represents an interesting response by which mammalian cells adapt to xenobiotic exposure. Polycyclic Aromatic Hydrocarbons 50-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-46 8860004-5 1996 Because of the importance of the CYP1A1 gene (which encodes the aromatic hydrocarbon hydroxylase) as a biomarker of genetic susceptibility to environmental carcinogens such as polycyclic aromatic hydrocarbons, these data may provide a useful reference for future studies of relationships between CYP1A1 genotype and disease susceptibility. Polycyclic Aromatic Hydrocarbons 176-208 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 8860004-5 1996 Because of the importance of the CYP1A1 gene (which encodes the aromatic hydrocarbon hydroxylase) as a biomarker of genetic susceptibility to environmental carcinogens such as polycyclic aromatic hydrocarbons, these data may provide a useful reference for future studies of relationships between CYP1A1 genotype and disease susceptibility. Polycyclic Aromatic Hydrocarbons 176-208 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 296-302 8631128-1 1996 Cytochrome CYP1A1 gene expression, induced by polycyclic aromatic hydrocarbons and dioxins, eg. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 11-17 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 13-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 127-152 8579379-2 1996 The extent of cytochrome P450IA1 (CYP1A1) induction in the liver correlated with the amount of 5- and 6-ring PAHs in the soil samples but not with the total PAH content. Polycyclic Aromatic Hydrocarbons 109-112 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 8579379-4 1996 The highest induction of CYP1A1 was obtained with a sample containing 274 mg 5- and 6-ring PAH/kg soil, resulting in a nearly 360-fold increase in the ethoxyresorufin deethylase (EROD) activity. Polycyclic Aromatic Hydrocarbons 91-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 8579379-5 1996 In a semilogarithmic plot, a linear correlation was found between the 5- and 6-ring PAH concentration in the soil and the microsomal CYP1A1 content. Polycyclic Aromatic Hydrocarbons 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 8729008-2 1996 One of these hemoproteins, cytochrome P4501A1, is most closely associated with the bioactivation of polycyclic aromatic hydrocarbons such as benzo[a]pyrene, which may play a role in environmental carcinogenesis. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-45 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 47-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 127-152 7663528-1 1995 CYP1A1 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 50-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 7627950-1 1995 Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-106 7627950-1 1995 Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-114 7627950-2 1995 A CYP1A1 polymorphism (isoleucine to valine substitution in exon 7) or the null allele for GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 135-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 2-8 20650112-8 1995 In conclusion, CYP1A1 mRNA induction was demonstrated in haemopoietic cells; inducers for CYP1A1 were not only a polycyclic aromatic hydrocarbon (BA), but also, unexpectedly, hydroxylated metabolites of benzene. Polycyclic Aromatic Hydrocarbons 113-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 20650112-8 1995 In conclusion, CYP1A1 mRNA induction was demonstrated in haemopoietic cells; inducers for CYP1A1 were not only a polycyclic aromatic hydrocarbon (BA), but also, unexpectedly, hydroxylated metabolites of benzene. Polycyclic Aromatic Hydrocarbons 113-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 90-96 7788860-10 1995 CYP1A1 and CYP1A2 mRNAs were detected in all the cells and several cultures were inducible by PAH exposure. Polycyclic Aromatic Hydrocarbons 94-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 7663528-1 1995 CYP1A1 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 7737047-6 1994 For example, a restriction fragment-length polymorphism for cytochrome P4501A1, which metabolizes polycyclic aromatic hydrocarbons, and cytochrome P4502E1, which metabolizes N-nitrosamines and benzene, is linked to lung cancer risk. Polycyclic Aromatic Hydrocarbons 98-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 60-78 7742722-1 1995 The human CYP1A1 gene codes for an inducible enzyme system involved in biotransformation of certain xenobiotics, including polycyclic aromatic hydrocarbons; some of the metabolites are carcinogenic and mutagenic. Polycyclic Aromatic Hydrocarbons 123-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 10-16 8830563-5 1995 Two enzymes of cytochrome P450, CYP1A1 and CYP1A2, are inducible by tobacco carcinogens, and animal studies evidenced a genetic polymorphism of CYP1A1 associated with tumour occurrence after administration of a polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 211-242 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 7581496-5 1995 Thus pulmonary CYP1A1 expression (inducibility) controls in part polycyclic aromatic hydrocarbon-DNA adduct formation in tobacco smokers and, therefore, appears to be associated with lung cancer risk. Polycyclic Aromatic Hydrocarbons 65-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 7581497-2 1995 Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 117-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 7901425-5 1993 These results demonstrate racially distinct patterns of CYP1A1 genotypes, and suggest a functional link between genotype and catalytic activity of the cytochrome P-450 protein responsible for the metabolism of many carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 228-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 7923575-8 1994 The results suggest that modestly induced CYP1A1 activity is a risk factor in polycyclic aromatic hydrocarbon-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 78-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 5-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 39-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8442004-0 1993 Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 86-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-22 8220094-2 1993 Recently described genetic polymorphisms for CYP1A1, a gene involved in the metabolic activation of polycyclic aromatic hydrocarbons, have been associated with lung cancer risk in a Japanese population. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 8386305-1 1993 In the presence of halogenated and polycyclic aromatic hydrocarbons, the CYP1A1 gene is regulated through induction after ligand binding to the cytosolic Ah receptor (AhR). Polycyclic Aromatic Hydrocarbons 35-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 8353849-2 1993 In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-34 8353849-2 1993 In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 8442004-1 1993 The cytochrome P4501 gene family consists of two members, CYP1A1 and CYP1A2, that are induced by halogenated hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 126-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 1362539-8 1992 A recently described restriction fragment length polymorphism for the CYP1A1, which codes for the cytochrome P450 enzyme primarily responsible for the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, has been found to be associated with lung cancer risk in a Japanese population. Polycyclic Aromatic Hydrocarbons 188-220 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 8093594-9 1993 These studies, along with our previous survey of CYP1A1 gene expression in creosote-exposed workers, add further support to the use of CYP1A1 gene inducibility as a potential marker of polycyclic aromatic hydrocarbon exposure in human populations. Polycyclic Aromatic Hydrocarbons 185-216 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 2235714-1 1990 Aromatic hydrocarbons hydroxylase (AHH)--an enzyme of monooxydases group--catalyzes hydroxylation of polycyclic aromatic hydrocarbons yielding compounds of the direct cancerogenic properties. Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-33 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-70 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-83 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-199 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 211-217 1316759-4 1992 In this study, we used the PAH isomers benzo[a]pyrene (BaP) and benzo[e]pyrene (BeP) to further evaluate the role of the 4S PAH-binding protein in induction of the CYP1A1 gene in H4-II-E rat hepatoma cells. Polycyclic Aromatic Hydrocarbons 124-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 164-170 1316759-10 1992 These results suggest that the 4S protein may play a role in the PAH-induced expression of the CYP1A1 gene in rat H4-II-E cells. Polycyclic Aromatic Hydrocarbons 65-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 2235714-1 1990 Aromatic hydrocarbons hydroxylase (AHH)--an enzyme of monooxydases group--catalyzes hydroxylation of polycyclic aromatic hydrocarbons yielding compounds of the direct cancerogenic properties. Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-38 2235714-5 1990 A significant increase in the incidence of neoplasms related to an exposition to PAH was noted in patients with increased AHH inducibility. Polycyclic Aromatic Hydrocarbons 81-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-125 35180652-1 2022 CYP1A1 enzyme is integral to the biotransformation of polycyclic aromatic hydrocarbons to carcinogenic compounds. Polycyclic Aromatic Hydrocarbons 54-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 34929281-10 2022 CYP1A1 and CYP1B1 adverse polymorphisms, familial BC history and smoking status, significantly strengthened the association between PAHs exposure and BC, whereas high fruit and vegetable intake had antagonistic associations. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 34242741-4 2021 The formation of these reactive metabolites entails metabolism of the parent PAHs by cytochrome P4501A1/1B1 (CYP1A1/1B1) and epoxide hydrolase enzymes. Polycyclic Aromatic Hydrocarbons 77-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-107 34242741-4 2021 The formation of these reactive metabolites entails metabolism of the parent PAHs by cytochrome P4501A1/1B1 (CYP1A1/1B1) and epoxide hydrolase enzymes. Polycyclic Aromatic Hydrocarbons 77-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-119 34242741-6 2021 PAH exposure also leads to upregulation of CYP1A1 transcription by binding to the aryl hydrocarbon receptor (AHR) and eliciting transcription of the CYP1A1 promoter, which comprises specific xenobiotic-responsive element (XREs). Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 34242741-6 2021 PAH exposure also leads to upregulation of CYP1A1 transcription by binding to the aryl hydrocarbon receptor (AHR) and eliciting transcription of the CYP1A1 promoter, which comprises specific xenobiotic-responsive element (XREs). Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-155 34242741-7 2021 While hepatic and pulmonary CYP1A1/1B1 metabolize PAHs to DNA-reactive metabolites, the hepatic CYP1A2, however, may protect against lung tumor development by suppressing both liver and lung CYP1A1 enzymes. Polycyclic Aromatic Hydrocarbons 50-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-34 34242741-8 2021 Further analysis of these enzymes has shown that PAH-exposure also induces sustained transcription of CYP1A1, which is independent of the persistence of the parent PAH. Polycyclic Aromatic Hydrocarbons 49-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 34242741-8 2021 Further analysis of these enzymes has shown that PAH-exposure also induces sustained transcription of CYP1A1, which is independent of the persistence of the parent PAH. Polycyclic Aromatic Hydrocarbons 164-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 35180652-0 2022 Polymorphisms in PAH metabolising enzyme CYP1A1 in colorectal cancer and their clinicopathological correlations. Polycyclic Aromatic Hydrocarbons 17-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 264-296 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-66 3839750-2 1985 The form of P-450 most closely associated with polynuclear aromatic hydrocarbons induction has been defined as P1-450. Polycyclic Aromatic Hydrocarbons 47-80 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 3839750-6 1985 Upon treatment with polynuclear aromatic hydrocarbons there is a positive correlation between induced arylhydrocarbon hydroxylase (flavoprotein-linked monoxygenase) activity and the amount of mRNA that hybridizes to the isolated human genomic clone for P1-450. Polycyclic Aromatic Hydrocarbons 20-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 253-259 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 298-301 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-60 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 298-301 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-66 33559210-7 2021 PAH exposures during differentiation did not alter monocyte-derived macrophage (MDM) numbers; however, B[a]A and 6-MIX exposures significantly altered M1/M2 polarization in a CYP1A1-dependent manner. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 175-181 33333309-0 2021 Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1. Polycyclic Aromatic Hydrocarbons 70-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-125 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 33333309-4 2021 van der Waals interactions (glide vdw) appeared to be important for PAH binding to CYP1A1 and were mainly affected by the molecular weight and hydrophobic structures of PAHs. Polycyclic Aromatic Hydrocarbons 68-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 32730838-13 2020 SIGNIFICANCE: These results partially indicated that VPA may augment the PAH-mediated induction of CYP1B1 and CYP1A1 through the activation of transcription by HDAC inhibition. Polycyclic Aromatic Hydrocarbons 73-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 32730838-0 2020 Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells. Polycyclic Aromatic Hydrocarbons 54-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-118 32730838-1 2020 AIMS: This study was performed to investigate the expression profile of cytochrome P450 (CYP) isoforms and effects of polycyclic aromatic hydrocarbons (PAHs) and antiepileptic drugs on CYP1 expression in human astrocytoma MOG-G-CCM cells. Polycyclic Aromatic Hydrocarbons 118-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 185-189 32730838-1 2020 AIMS: This study was performed to investigate the expression profile of cytochrome P450 (CYP) isoforms and effects of polycyclic aromatic hydrocarbons (PAHs) and antiepileptic drugs on CYP1 expression in human astrocytoma MOG-G-CCM cells. Polycyclic Aromatic Hydrocarbons 152-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 185-189 33023449-1 2021 CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic compounds. Polycyclic Aromatic Hydrocarbons 109-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-33 33283556-11 2020 Conclusion: CYP1A1 and CYP1B1 are known to cause lung cancer by metabolizing polycyclic aromatic hydrocarbons, and long noncoding RNA is also known to play an important role in lung cancer. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 31358014-0 2019 CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 154-186 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-64 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 154-186 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-64 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 31358014-11 2019 CONCLUSIONS: Our findings suggested that the co-exposure effect of smoking and occupational PAH could increase the risk of oxidative DNA damage by a mechanism partly involving CYP1A1 hypomethylation. Polycyclic Aromatic Hydrocarbons 92-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 31655123-1 2020 Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 31655123-1 2020 Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 31051230-3 2019 The present work aimed to investigate the role of CYP1A1 gene in PAH-mediated growth and tumor development in vitro and using an in vivo animal model. Polycyclic Aromatic Hydrocarbons 65-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 31051230-5 2019 Treatment of PAH-induced human alveolar adenocarcinoma cell line with cationic liposomes carrying CYP1A1 siRNA resulted in down regulation of CYP1A1 mRNA, protein as well as its enzymatic activity, triggering apoptosis and inhibiting multicellular tumor spheroids formation in vitro. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 31051230-5 2019 Treatment of PAH-induced human alveolar adenocarcinoma cell line with cationic liposomes carrying CYP1A1 siRNA resulted in down regulation of CYP1A1 mRNA, protein as well as its enzymatic activity, triggering apoptosis and inhibiting multicellular tumor spheroids formation in vitro. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 142-148 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 142-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-33 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 142-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 142-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 30448188-2 2018 Hence, phytochemicals or dietary flavonoids, if identified as CYP1A1 inhibitors, may help in preventing PAH-mediated carcinogenesis and breast cancer. Polycyclic Aromatic Hydrocarbons 104-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 29845565-0 2018 Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 159-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-58 28632937-1 2017 Cytochromes P450 family 1 (CYP1) are responsible for the metabolism of procarcinogens, for example polycyclic aromatic hydrocarbons and aromatic and heterocyclic amines. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-92 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 29458109-2 2018 CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens. Polycyclic Aromatic Hydrocarbons 86-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 29458109-3 2018 CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins. Polycyclic Aromatic Hydrocarbons 185-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 28632937-1 2017 Cytochromes P450 family 1 (CYP1) are responsible for the metabolism of procarcinogens, for example polycyclic aromatic hydrocarbons and aromatic and heterocyclic amines. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-31 28710019-0 2017 Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 286-311 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 286-311 27565807-8 2016 We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 66-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 100-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 303-335 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 337-341 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 27565807-8 2016 We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 168-174 27486223-6 2016 The resulting CYP1A1/CYP1B1 enzymes are responsible for PAH first pass metabolism, which can result in the generation of toxic intermediates and perhaps AHR-associated toxicities. Polycyclic Aromatic Hydrocarbons 56-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 144-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 27706624-5 2016 A large number of genetic polymorphisms has been reported for CYP1A1, the gene that is responsible for enzymes involved in stage I detoxification of xenobiotics; this gene is located at 15q22-24, and encodes an isoenzyme that catalyzes the oxidation of polycyclic aromatic hydrocarbons present in phenolic compounds and epoxides. Polycyclic Aromatic Hydrocarbons 253-285 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 177-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 27285958-2 2016 RECENT FINDINGS: Components of tobacco smoke such as polycyclic aromatic hydrocarbons lead to transcriptional upregulation of a number of genes, including members of the cytochrome P450 (CYP) family, in particular CYP1B1 and CYP1A1. Polycyclic Aromatic Hydrocarbons 53-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 225-231 25555259-6 2015 These findings indicate that differential Cyp1a1 and Cyp1a2 expression in the H4IIE cells might be used for detection of PAHs in highly contaminated environmental mixtures, but not in low-concentration mixtures of these compounds. Polycyclic Aromatic Hydrocarbons 121-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 27243113-3 2016 CYP1A1*2A (6235 T/C, rs4646903, MspI) is thought to be associated with an increased risk of CRC because of its role in metabolic activation of polycyclic aromatic hydrocarbons; however, the results of previous studies are conflicting. Polycyclic Aromatic Hydrocarbons 143-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 25398514-0 2016 Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 13-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 26082767-5 2015 More specifically, we will discuss the role of CYP1A1 and CYP1B1, which are the major PAH-activating CYP enzymes. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 47-53 26082767-7 2015 CSC contains PAH, which are known to be activated by CYP1A1 and CYP1B1 into procarcinogens/toxic metabolites. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 25555259-0 2015 Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs. Polycyclic Aromatic Hydrocarbons 99-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-33 24761888-0 2014 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 25343551-1 2014 AIMS AND BACKGROUND: Cytochrome P450 (CYP) 1A1 enzyme plays an important role in the metabolism of carcinogens, such as polycyclic aromatic hydrocarbons, nitroaromatics and arylamines. Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-46 24847427-1 2014 OBJECTIVE(S): Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. Polycyclic Aromatic Hydrocarbons 123-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-34 24847427-1 2014 OBJECTIVE(S): Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. Polycyclic Aromatic Hydrocarbons 157-161 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-34 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 36-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-141 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 36-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 69-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-141 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 69-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 168-171 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 23845848-1 2013 Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P450 monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Polycyclic Aromatic Hydrocarbons 24-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128 23845848-1 2013 Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P450 monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Polycyclic Aromatic Hydrocarbons 58-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128 23508959-2 2013 CYP1A1 is particularly well known for its ability to biotransform polycyclic aromatic hydrocarbons, such as benzo[a]pyrene in tobacco smoke, into carcinogens. Polycyclic Aromatic Hydrocarbons 66-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 23816456-4 2013 Therefore, we examined the role of haplotype based-CYP1A1 polymorphism in the effect of PAHs exposure on lung function in 422 participants from a community-based panel of elderly adults in Seoul, Korea. Polycyclic Aromatic Hydrocarbons 88-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 22388733-1 2013 The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression. Polycyclic Aromatic Hydrocarbons 121-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 157-174 22388733-1 2013 The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression. Polycyclic Aromatic Hydrocarbons 121-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-180 23733671-2 2013 The expression of CYP1A1 induces polycyclic aromatic hydrocarbon production in the lungs, which when over expressed, is known to cause smoking related diseases, such as cardiovascular pathologies, cancer, and diabetes. Polycyclic Aromatic Hydrocarbons 33-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-24 23475304-1 2013 Cytochrome P450 1A1 (CYP1A1), an important phase I xenobiotic metabolizing enzyme, is responsible for metabolizing numerous carcinogens, particularly polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 23475304-1 2013 Cytochrome P450 1A1 (CYP1A1), an important phase I xenobiotic metabolizing enzyme, is responsible for metabolizing numerous carcinogens, particularly polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 23111888-1 2013 This study aimed to determine whether the coding (A4889G) and noncoding region (T6235C) polymorphisms of the gene coding for cytochrome P4501A1 (CYP1A1), a xenobiotic-metabolizing enzyme responsible for the metabolism of carcinogenic polycyclic aromatic hydrocarbons, are involved in the pathogenesis of ischemic stroke in Turkish population. Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 125-143 23111888-1 2013 This study aimed to determine whether the coding (A4889G) and noncoding region (T6235C) polymorphisms of the gene coding for cytochrome P4501A1 (CYP1A1), a xenobiotic-metabolizing enzyme responsible for the metabolism of carcinogenic polycyclic aromatic hydrocarbons, are involved in the pathogenesis of ischemic stroke in Turkish population. Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 145-151 21913209-6 2013 PAH within air pollution PM(2.5) induced CYP1A1 gene expression but not CYP1A1 catalytic activity in L132 cells. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 21876539-7 2012 CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. Polycyclic Aromatic Hydrocarbons 30-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22404339-6 2012 Organic chemicals adsorbed on the three PM2.5-0.3 samples (i.e., polycyclic aromatic hydrocarbons) were able to induce the gene expression of xenobiotic-metabolizing enzymes (i.e., Cytochrome P4501A1 and 1B1, and, to a lesser extent, NADPH-quinone oxidoreductase-1). Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-207 22213191-1 2012 CYP1A1 (cytochrome P4501A1) catalyze the conversion of polycyclic aromatic hydrocarbons into reactive metabolites, which may induce DNA damage. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22213191-1 2012 CYP1A1 (cytochrome P4501A1) catalyze the conversion of polycyclic aromatic hydrocarbons into reactive metabolites, which may induce DNA damage. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-26 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 71-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-136 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 184-188 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-136 22374940-3 2012 Inhibitors of Hsp90 ATPase cause a rapid decrease in levels of AhR, an Hsp90 client protein, and thereby block PAH-mediated induction of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 111-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 22374940-4 2012 The main objective of this study was to determine whether Zyflamend, a polyherbal preparation, suppressed PAH-mediated induction of CYP1A1 and CYP1B1 and inhibited DNA adduct formation and mutagenesis. Polycyclic Aromatic Hydrocarbons 106-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-138 22945568-5 2012 In particular, CYP1A1 and 1B1 catalyze oxidation of PAHs toward primary epoxide species that can further be converted into multiple follow-up products, both nonenzymatically and enzymatically. Polycyclic Aromatic Hydrocarbons 52-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-29 22198330-3 2012 Many enzymes involved in PAH metabolism, including CYP1A1, CYP1B1, GSTM and GSTT are polymorphic, which may modulate the activation/deactivation of these compounds. Polycyclic Aromatic Hydrocarbons 25-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 22198330-9 2012 We observed higher 1-OHP concentrations in children with CYP1A1*2C or GSTM1*0 polymorphisms, and a positive influence of CYP1A1*2C on OTM values in children with the highest PAH exposure. Polycyclic Aromatic Hydrocarbons 174-177 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-127 24323584-5 2011 CYP1A1 is the phase I metabolizing enzyme which plays a key role in metabolic activation of polycyclic aromatic hydrocarbons which are present in cigarette smoke and considered carcinogenic. Polycyclic Aromatic Hydrocarbons 92-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 21882217-9 2011 In Latino Americans, the lung cancer risks associated with polycyclic aromatic hydrocarbon-related exposures were consistently higher in the CYP1A1 wild-type subjects as compared to the variant genotype subjects, and the interaction was statistically significant for smoking and the CYP1A1 M2 polymorphism (P-value(interaction) = 0.02). Polycyclic Aromatic Hydrocarbons 59-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 141-147 21882217-9 2011 In Latino Americans, the lung cancer risks associated with polycyclic aromatic hydrocarbon-related exposures were consistently higher in the CYP1A1 wild-type subjects as compared to the variant genotype subjects, and the interaction was statistically significant for smoking and the CYP1A1 M2 polymorphism (P-value(interaction) = 0.02). Polycyclic Aromatic Hydrocarbons 59-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 283-289 21669939-1 2011 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 25-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-106 21669939-1 2011 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 59-63 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-106 21669939-1 2011 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 135-139 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-106 21376804-3 2011 Enzymes such as CYP1A1/1B1 and CYP2A6/2A13 activate polycyclic aromatic hydrocarbons and nitrosamines, respectively. Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-26 22096847-11 2011 CONCLUSION: The results of present study suggested that PAHs exposure could induce the shorted RTL, CYP1A1, mEH, AHR polymorphisms might influence the change of telomere length of genomic DNA in peripheral blood of workers exposed to PAHs. Polycyclic Aromatic Hydrocarbons 56-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 21402622-1 2011 The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. Polycyclic Aromatic Hydrocarbons 264-296 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-23 21402622-1 2011 The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. Polycyclic Aromatic Hydrocarbons 264-296 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 21081473-3 2011 We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls) and CRC (496 cases, 607 controls) among Japanese Americans, European Americans and Native Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with smoking and intakes of red meat and HAAs. Polycyclic Aromatic Hydrocarbons 242-245 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 277-283 21646728-1 2011 Cytochrome P450 (CYP) 1A1 is involved in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and is induced by several compounds, including PAHs. Polycyclic Aromatic Hydrocarbons 69-101 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 21646728-1 2011 Cytochrome P450 (CYP) 1A1 is involved in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and is induced by several compounds, including PAHs. Polycyclic Aromatic Hydrocarbons 103-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 21646728-1 2011 Cytochrome P450 (CYP) 1A1 is involved in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and is induced by several compounds, including PAHs. Polycyclic Aromatic Hydrocarbons 156-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 21787681-2 2011 CYP1A1 and GSTs enzymes are important in metabolism of PAHs. Polycyclic Aromatic Hydrocarbons 55-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 20961953-10 2011 Coplanar PCB concentrations were generally higher in Ahr(d)-containing pup tissues; these findings are consistent with earlier studies demonstrating the crucial importance of AHR-mediated inducible CYP1 in the gastrointestinal tract as a means of detoxication of oral planar polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 275-307 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-202