PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 93-125 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 47-51 9206005-4 1997 In addition to these enzymes, P450 monooxygenases in some fungi were implicated in the degradation of PAHs. Polycyclic Aromatic Hydrocarbons 102-106 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 30-34 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 47-51 8954573-11 1996 The markedly variable effects of these PAHs and resorufins on the CO binding kinetics indicate differential modes of interaction with the two target P450 1A1 species, resulting in differential modulation of their conformations. Polycyclic Aromatic Hydrocarbons 39-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 149-153 8571359-2 1995 Many xenobiotics including pesticides, nitrosamines, polycyclic aromatic hydrocarbons and halogenated hydrocarbons, require bioactivation by P450 enzymes to elicit toxicity. Polycyclic Aromatic Hydrocarbons 53-85 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 141-145 1306334-3 1992 Different P450 forms are responsible for activation of the various classes of chemical carcinogens including the arylamines, polycyclic aromatic hydrocarbons, nitrosamines and aflatoxins. Polycyclic Aromatic Hydrocarbons 125-157 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 10-14 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 66-98 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 28648140-2 2018 1-Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4 and 3A5. Polycyclic Aromatic Hydrocarbons 59-90 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 147-158 1588920-13 1992 Thus, this work clearly shows that human lung microsomes contain at least two major P-450 enzymes; human P-450 1A1 is present in lungs and can actually catalyze the activation of environmental procarcinogens, including polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 219-251 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 84-89 1588920-13 1992 Thus, this work clearly shows that human lung microsomes contain at least two major P-450 enzymes; human P-450 1A1 is present in lungs and can actually catalyze the activation of environmental procarcinogens, including polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 219-251 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 105-110 2882985-0 1987 Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes. Polycyclic Aromatic Hydrocarbons 78-109 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 134-139 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 100-104 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 23886934-1 2013 Cytochrome P450 (P450, CYP) 1 family plays a primary role in the detoxification and bioactivation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-29 16719376-1 2006 Cytochrome P450 (P450) enzymes belonging to the CYP1 family are highly inducible by polycyclic aromatic hydrocarbons and other environmental chemicals and play a major role in the metabolism of many foreign chemicals and endogenous substances. Polycyclic Aromatic Hydrocarbons 84-116 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-21 17292855-2 2007 Three PAH were found to be substrates for the oxidation by P450(BSbeta), namely anthracene, 9-methyl-anthracene and azulene. Polycyclic Aromatic Hydrocarbons 6-9 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 59-71 15279838-1 2004 We newly developed 10 Salmonela typhimurium TA1538 strains each co-expressing a form of human cytochrome P450s (P450 or CYP) together with NADPH-cytochrome P450 reductase (CPR) for highly sensitive detection of mutagenic activation of mycotoxins, polycyclic aromatic hydrocarbons, heterocyclic amines, and aromatic amines at low substrate concentrations. Polycyclic Aromatic Hydrocarbons 247-279 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 94-123