PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 epoxide hydrolase 1 Homo sapiens 44-72 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 epoxide hydrolase 1 Homo sapiens 74-79 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 epoxide hydrolase 1 Homo sapiens 44-72 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 epoxide hydrolase 1 Homo sapiens 74-79 26655675-11 2016 We found significant gene-environment interaction between PAH and four SNPs (EPHX1, (rs2854461), STAT4 (rs16833215), XPC (rs2228001 and rs2733532)), which became non-significant after adjusting for multiple comparisons. Polycyclic Aromatic Hydrocarbons 58-61 epoxide hydrolase 1 Homo sapiens 77-82 15466980-2 2004 Cytochrome P450, glutathione S-transferase, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, and N-acetyltransferase are PAH-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 134-137 epoxide hydrolase 1 Homo sapiens 44-72 11489754-1 2001 Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat. Polycyclic Aromatic Hydrocarbons 47-79 epoxide hydrolase 1 Homo sapiens 0-28 9224217-2 1997 PAH are converted to carcinogenic molecules through a combination of monoxygenation by cytochrome p450 (CYP) enzymes in the presence of NADPH oxidoreductase (OR) and hydrolysis by microsomal epoxide hydrolase (mEH). Polycyclic Aromatic Hydrocarbons 0-3 epoxide hydrolase 1 Homo sapiens 180-208 15668489-2 2005 Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 49-81 epoxide hydrolase 1 Homo sapiens 0-28 15668489-2 2005 Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 49-81 epoxide hydrolase 1 Homo sapiens 30-35 23889309-0 2001 Benzo(a)pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes. Polycyclic Aromatic Hydrocarbons 68-100 epoxide hydrolase 1 Homo sapiens 153-157 31348278-0 2019 The effect on congenital heart diseases of maternal EPHX1 polymorphisms modified by polycyclic aromatic hydrocarbons exposure. Polycyclic Aromatic Hydrocarbons 84-116 epoxide hydrolase 1 Homo sapiens 52-57 31348278-6 2019 A possible modifying effect of PAHs exposure on genetic polymorphisms of EPHX1 was found in susceptibility to CHDs, though no multiplicative-scale interactions between maternal exposure to PAHs and polymorphisms of EPHX1 gene were seento affect the risk of CHDs.The role of EPHX1 gene polymorphisms for CHDs need to be further evaluated, in particularly by interacting with PAHs exposure. Polycyclic Aromatic Hydrocarbons 31-35 epoxide hydrolase 1 Homo sapiens 73-78 31348278-6 2019 A possible modifying effect of PAHs exposure on genetic polymorphisms of EPHX1 was found in susceptibility to CHDs, though no multiplicative-scale interactions between maternal exposure to PAHs and polymorphisms of EPHX1 gene were seento affect the risk of CHDs.The role of EPHX1 gene polymorphisms for CHDs need to be further evaluated, in particularly by interacting with PAHs exposure. Polycyclic Aromatic Hydrocarbons 31-35 epoxide hydrolase 1 Homo sapiens 215-220 31348278-6 2019 A possible modifying effect of PAHs exposure on genetic polymorphisms of EPHX1 was found in susceptibility to CHDs, though no multiplicative-scale interactions between maternal exposure to PAHs and polymorphisms of EPHX1 gene were seento affect the risk of CHDs.The role of EPHX1 gene polymorphisms for CHDs need to be further evaluated, in particularly by interacting with PAHs exposure. Polycyclic Aromatic Hydrocarbons 31-35 epoxide hydrolase 1 Homo sapiens 215-220 22352736-2 2012 Microsomal epoxide hydrolase (EPHX1) has an important role in the metabolism of polycyclic aromatic hydrocarbons and detoxification of procarcinogens. Polycyclic Aromatic Hydrocarbons 80-112 epoxide hydrolase 1 Homo sapiens 0-28 24260161-5 2013 RESULTS: We found positive interaction odds ratios (ORs) for both maternal and paternal smoking during pregnancy, EPHX1 H139R, and childhood brain tumors (P(interaction) = 0.02; 0.10), such that children with the high-risk (greater PAH activation) genotype were at a higher risk of brain tumors relative to children with the low-risk genotype when exposed to tobacco smoke during pregnancy. Polycyclic Aromatic Hydrocarbons 232-235 epoxide hydrolase 1 Homo sapiens 114-119 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 epoxide hydrolase 1 Homo sapiens 126-131 22415791-1 2013 Microsomal epoxide hydrolase (EPHX1) plays an important role in the activation and detoxification of polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 101-133 epoxide hydrolase 1 Homo sapiens 0-28 22415791-1 2013 Microsomal epoxide hydrolase (EPHX1) plays an important role in the activation and detoxification of polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 101-133 epoxide hydrolase 1 Homo sapiens 30-35 24266295-2 2013 The first phase of xenobiotic biotransformation in the PAH metabolism includes activities of cytochrome P450 from the CYP1 family and microsomal epoxide hydrolase. Polycyclic Aromatic Hydrocarbons 55-58 epoxide hydrolase 1 Homo sapiens 134-162 24615030-1 2014 Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Polycyclic Aromatic Hydrocarbons 184-216 epoxide hydrolase 1 Homo sapiens 32-37 23681797-1 2013 Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in the detoxification of carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 101-133 epoxide hydrolase 1 Homo sapiens 32-37 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 247-279 epoxide hydrolase 1 Homo sapiens 0-28 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 247-279 epoxide hydrolase 1 Homo sapiens 35-40 23055191-1 2013 Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in both the activation and the detoxification of polycyclic aromatic hydrocarbons and aromatic amines. Polycyclic Aromatic Hydrocarbons 112-144 epoxide hydrolase 1 Homo sapiens 32-37 22352736-2 2012 Microsomal epoxide hydrolase (EPHX1) has an important role in the metabolism of polycyclic aromatic hydrocarbons and detoxification of procarcinogens. Polycyclic Aromatic Hydrocarbons 80-112 epoxide hydrolase 1 Homo sapiens 30-35 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 79-111 epoxide hydrolase 1 Homo sapiens 24-52 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 79-111 epoxide hydrolase 1 Homo sapiens 54-59 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 116-119 epoxide hydrolase 1 Homo sapiens 24-52 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 116-119 epoxide hydrolase 1 Homo sapiens 54-59