PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32797326-8	2020	Furthermore, in vitro studies suggest ibuprofen may facilitate cleavage of ACE2 from the membrane, preventing membrane-dependent viral entry into the cell, the clinical significance of which is uncertain.	Ibuprofen	38-47	angiotensin converting enzyme 2	Homo sapiens	75-79	
32506743-2	2020	It has been hypothesized that ACE2 expression can be increased by Ibuprofen leading to a higher risk for severe COVID-19 (1).	Ibuprofen	66-75	angiotensin converting enzyme 2	Homo sapiens	30-34	
32415494-1	2020	Scientists hypothesized that drugs such as ibuprofen or renin-angiotensin system (RAS) blockers could exacerbate the novel coronavirus disease COVID-19 by upregulating the angiotensin-converting enzyme 2 (ACE2), which serves as an entry receptor for the coronavirus SARS-CoV-2.	Ibuprofen	43-52	angiotensin converting enzyme 2	Homo sapiens	172-203	
32366740-3	2020	A concern was raised regarding the safety of ibuprofen use because of its role in increasing ACE2 levels within the Renin-Angiotensin-Aldosterone system.	Ibuprofen	45-54	angiotensin converting enzyme 2	Homo sapiens	93-97	
32366740-4	2020	ACE2 is the coreceptor for the entry of SARS-CoV-2 into cells, and so, a potential increased risk of contracting COVID-19 disease and/or worsening of COVID-19 infection was feared with ibuprofen use.	Ibuprofen	185-194	angiotensin converting enzyme 2	Homo sapiens	0-4	
32366740-5	2020	However, available data from limited studies show administration of recombinant ACE2 improves lung damage caused by respiratory viruses, suggesting ibuprofen use may be beneficial in COVID-19 disease.	Ibuprofen	148-157	angiotensin converting enzyme 2	Homo sapiens	80-84	
32277367-7	2020	Angiotensin converting enzyme 2 (ACE2) appears important for viral entry into pneumocytes; dysbalance in ACE2 as caused by ACE inhibitors or ibuprofen may predispose to severe disease.	Ibuprofen	141-150	angiotensin converting enzyme 2	Homo sapiens	105-109	
32415494-1	2020	Scientists hypothesized that drugs such as ibuprofen or renin-angiotensin system (RAS) blockers could exacerbate the novel coronavirus disease COVID-19 by upregulating the angiotensin-converting enzyme 2 (ACE2), which serves as an entry receptor for the coronavirus SARS-CoV-2.	Ibuprofen	43-52	angiotensin converting enzyme 2	Homo sapiens	205-209	
35162972-2	2022	Early in the pandemic, there was speculation that a number of commonly used medications-including ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs)-have the potential to upregulate ACE2, thereby possibly facilitating viral entry and increasing the severity of COVID-19.	Ibuprofen	98-107	angiotensin converting enzyme 2	Homo sapiens	198-202