PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24173829-0	2014	S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines.	Ibuprofen	1-14	tumor protein p53	Homo sapiens	56-59	
29541415-2	2018	We found that NSAIDs including celecoxib (CCB) and ibuprofen (IBU) significantly potentiated the cytotoxicity of Hsp90 inhibitors in human multidrug-resistant (MDR) cells expressing high levels of mutant p53 (mutp53) protein and P-glycoprotein (P-gp), and reversed Hsp90 inhibitor resistance caused by activation of heat shock factor 1 (HSF1) and by up-regulation of heat shock proteins (Hsps) and P-gp.	Ibuprofen	51-60	tumor protein p53	Homo sapiens	204-207	
29541415-2	2018	We found that NSAIDs including celecoxib (CCB) and ibuprofen (IBU) significantly potentiated the cytotoxicity of Hsp90 inhibitors in human multidrug-resistant (MDR) cells expressing high levels of mutant p53 (mutp53) protein and P-glycoprotein (P-gp), and reversed Hsp90 inhibitor resistance caused by activation of heat shock factor 1 (HSF1) and by up-regulation of heat shock proteins (Hsps) and P-gp.	Ibuprofen	62-65	tumor protein p53	Homo sapiens	204-207	
25542229-6	2015	Real-time RT-PCR showed that ibuprofen altered the expression of several genes including Akt, P53, PCNA, Bax, and Bcl2 in the AGS cells.	Ibuprofen	29-38	tumor protein p53	Homo sapiens	94-97	
26004413-5	2015	Here we review the current knowledge on COX-independent effects of ibuprofen, which affect changes in gene expression or alternative splicing and act through various cell cycle- and apoptosis-regulating pathways, including beta-catenin, NF-kappaB, PPARgamma and p53.	Ibuprofen	67-76	tumor protein p53	Homo sapiens	262-265	
24173829-9	2014	Gene expression profile and Ingenuity pathway analyses using TP53-mutated SKNAS cells further revealed that S(+)-ibuprofen suppressed molecular pathways associated with cell growth and conversely enhanced those of cell cycle arrest and the unfolded protein response.	Ibuprofen	109-122	tumor protein p53	Homo sapiens	61-65	
20548326-9	2011	Ibuprofen induced ROS, which resulted in cellular alterations that promoted a p53-dependent G(1) blockade.	Ibuprofen	0-9	tumor protein p53	Homo sapiens	78-81	
21516318-9	2011	Recent use of ibuprofen was significantly associated with increased risk of ER+/PR+(OR 1.33, 95% CI: 1.09-1.62), HER2- (OR 1.27, 95% CI: 1.05-1.53), and p53- breast cancers (OR 1.28, 95% CI: 1.04-1.57), as well as luminal A or B breast cancers.	Ibuprofen	14-23	tumor protein p53	Homo sapiens	153-156	
20548326-6	2011	Genes involved in the "biological oxidation" and "G(1)/S checkpoint" pathways were the most significantly represented at 24 h, whereas genes involved in the "cell cycle" and "DNA replication" pathways were represented at 48 and 72 h. Genes associated with the "apoptosis" pathway were also significantly represented at 72 h. Modulation of the expression of p53 and p53-induced genes (CDKN1A/p21 and GADD45), which are involved in the G(1)/S transition, suggested an effect of ibuprofen on cell-cycle progression.	Ibuprofen	476-485	tumor protein p53	Homo sapiens	357-360	
20548326-6	2011	Genes involved in the "biological oxidation" and "G(1)/S checkpoint" pathways were the most significantly represented at 24 h, whereas genes involved in the "cell cycle" and "DNA replication" pathways were represented at 48 and 72 h. Genes associated with the "apoptosis" pathway were also significantly represented at 72 h. Modulation of the expression of p53 and p53-induced genes (CDKN1A/p21 and GADD45), which are involved in the G(1)/S transition, suggested an effect of ibuprofen on cell-cycle progression.	Ibuprofen	476-485	tumor protein p53	Homo sapiens	365-368	
19452524-7	2009	Ibuprofen-type drugs, IL6 polymorphisms (rs1800796) and dietary alpha-tocopherol and lycopene significantly altered likelihood of having a TP53 mutation.	Ibuprofen	0-9	tumor protein p53	Homo sapiens	139-143	
19452524-8	2009	This was especially true for TP53 transversion mutations and dietary antioxidants (OR for beta-carotene 0.51 95% CI 0.27, 0.97, p trend 0.03; alpha-tocopherol 0.41 95% CI 0.20, 0.84, p trend 0.02) Beta-carotene and ibuprofen significantly altered risk of KRAS2 tumors.	Ibuprofen	215-224	tumor protein p53	Homo sapiens	29-33	
18036557-0	2008	p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells.	Ibuprofen	54-63	tumor protein p53	Homo sapiens	0-3	
18036557-4	2008	Furthermore, results indicate that induction of apoptosis in HCT-116 p53(wt) cells after ibuprofen treatment is in part dependent on a signalling pathway including the neutrophin receptor p75(NTR), p53 and Bax.	Ibuprofen	89-98	tumor protein p53	Homo sapiens	69-72	
18036557-4	2008	Furthermore, results indicate that induction of apoptosis in HCT-116 p53(wt) cells after ibuprofen treatment is in part dependent on a signalling pathway including the neutrophin receptor p75(NTR), p53 and Bax.	Ibuprofen	89-98	tumor protein p53	Homo sapiens	198-201	
31970141-3	2019	We evaluated the effects of ectopic expression of p53 on the biological functions of ibuprofen and diclofenac.	Ibuprofen	85-94	tumor protein p53	Homo sapiens	50-53