PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29593094-1 2018 In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity. Polysaccharides 132-139 fucosyltransferase 4 Homo sapiens 163-167 9461592-3 1998 To begin to understand the biosynthesis of these glycans, we have characterized the acceptor and site specificities of the two granulocyte alpha1,3-fucosyltransferases, Fuc-TIV and Fuc-TVII, using recombinant forms of these two enzymes and a panel of synthetic polylactosamine-based acceptors. Polysaccharides 49-56 fucosyltransferase 4 Homo sapiens 169-176 10103052-4 1999 Mimicking some of these saccharide structures, we have synthesized enzymatically a bivalent [sialyl diLex]-glycan, Neu5Acalpha2-3"Lexbeta1-3"Lexbeta1-3"(Neu5Acalpha2-3"Lexbeta1-3Lexbe ta1-6")LN [where Neu5Ac is N-acetylneuraminic acid, Lex is the trisaccharide Galbeta1-4(Fucalpha1-3)GlcNAc and LN is the disaccharide Galbeta1-4GlcNAc]. Polysaccharides 107-113 fucosyltransferase 4 Homo sapiens 102-105 30867744-4 2019 The glycans Lewis X (LeX), Sialyl lewis X (SLeX) and Sialyl Tn (STn) have previously been associated with aggressiveness, dissemination and poor prognosis in human bladder cancer, additionally N-glycolyl GM3 (NGcGM3) is a neo-antigen expressed in many types of tumors; however, to the best of our knowledge, its expression has not previously been assessed in this type of cancer. Polysaccharides 4-11 fucosyltransferase 4 Homo sapiens 12-19 30867744-4 2019 The glycans Lewis X (LeX), Sialyl lewis X (SLeX) and Sialyl Tn (STn) have previously been associated with aggressiveness, dissemination and poor prognosis in human bladder cancer, additionally N-glycolyl GM3 (NGcGM3) is a neo-antigen expressed in many types of tumors; however, to the best of our knowledge, its expression has not previously been assessed in this type of cancer. Polysaccharides 4-11 fucosyltransferase 4 Homo sapiens 21-24 29593094-1 2018 In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity. Polysaccharides 132-139 fucosyltransferase 4 Homo sapiens 149-156 29593094-1 2018 In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity. Polysaccharides 132-139 fucosyltransferase 4 Homo sapiens 158-161 29593094-1 2018 In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity. Polysaccharides 132-139 fucosyltransferase 4 Homo sapiens 183-190 29182943-5 2018 Additionally, sperm were analyzed for motility characteristics, acrosome status, and binding to the two oviduct glycan motifs that bind porcine sperm, biantennary 6-sialylated N-acetyllactosamine on a mannose core (bi-SiaLN) and sulfated LeX trisaccharide (suLeX). Polysaccharides 112-118 fucosyltransferase 4 Homo sapiens 238-241 29210428-7 2017 This is one of the few examples of MSNs using biologically relevant glycans for both capping (via interaction with AAL) and targeting (via interaction with overexpressed Lex at the cell membrane). Polysaccharides 68-75 fucosyltransferase 4 Homo sapiens 170-173 29432456-3 2018 Using flow cytometric analysis of primary human jejunal epithelial cells and granulocytes, we now show that CTB binding correlates with expression of the fucosylated Lewis X (LeX) glycan. Polysaccharides 180-186 fucosyltransferase 4 Homo sapiens 175-178 29432456-5 2018 CTB binds the LeX glycan in vitro when this moiety is linked to proteins but not to ceramides, and this binding can be blocked by mAb to LeX. Polysaccharides 18-24 fucosyltransferase 4 Homo sapiens 14-17 29432456-5 2018 CTB binds the LeX glycan in vitro when this moiety is linked to proteins but not to ceramides, and this binding can be blocked by mAb to LeX. Polysaccharides 18-24 fucosyltransferase 4 Homo sapiens 137-140 29210428-0 2017 Lectin-gated and glycan functionalized mesoporous silica nanocontainers for targeting cancer cells overexpressing Lewis X antigen. Polysaccharides 17-23 fucosyltransferase 4 Homo sapiens 114-121 28600306-1 2017 PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium. Polysaccharides 26-33 fucosyltransferase 4 Homo sapiens 74-81 28600306-1 2017 PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium. Polysaccharides 26-33 fucosyltransferase 4 Homo sapiens 83-86 28600306-1 2017 PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium. Polysaccharides 26-33 fucosyltransferase 4 Homo sapiens 99-106 28600306-1 2017 PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium. Polysaccharides 26-32 fucosyltransferase 4 Homo sapiens 74-81 28600306-1 2017 PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium. Polysaccharides 26-32 fucosyltransferase 4 Homo sapiens 83-86 28600306-1 2017 PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium. Polysaccharides 26-32 fucosyltransferase 4 Homo sapiens 99-106 28600306-2 2017 Although glycans, such as Lex and sLex, which are based on the type 2 sequence (Galbeta1-4GlcNAc-R), are abundant on PMNs, the presence of type 1 Galbeta1-3GlcNAc-R glycans required for PMN expression of the closely related stereoisomer of Lex, termed Lewis-A (Lea), has not, to our knowledge, been reported. Polysaccharides 9-16 fucosyltransferase 4 Homo sapiens 26-29 28600306-2 2017 Although glycans, such as Lex and sLex, which are based on the type 2 sequence (Galbeta1-4GlcNAc-R), are abundant on PMNs, the presence of type 1 Galbeta1-3GlcNAc-R glycans required for PMN expression of the closely related stereoisomer of Lex, termed Lewis-A (Lea), has not, to our knowledge, been reported. Polysaccharides 9-16 fucosyltransferase 4 Homo sapiens 35-38 26687991-5 2016 Herein, we show that antibody blockade of Lewis X (Le(x)) displayed as terminal glycan residues on the PMN surface blocks chemotaxis and TEM while enhancing PMN-adhesive interactions with intestinal epithelia. Polysaccharides 80-86 fucosyltransferase 4 Homo sapiens 51-56 26687991-6 2016 Unexpectedly, targeting of subterminal Le(x) residues within glycan chains had no effect on PMN migration or adhesive interactions. Polysaccharides 61-67 fucosyltransferase 4 Homo sapiens 39-44 23542315-6 2013 The results demonstrated that F8A1.1 recognized glycans expressing Le(x) epitopes in a terminal nonreducing position, whereas anti-CD15 bound to glycans with multiple repeats of Le(x) epitopes, but not to glycans with a single, terminal Le(x) epitope. Polysaccharides 145-152 fucosyltransferase 4 Homo sapiens 131-135 23542315-6 2013 The results demonstrated that F8A1.1 recognized glycans expressing Le(x) epitopes in a terminal nonreducing position, whereas anti-CD15 bound to glycans with multiple repeats of Le(x) epitopes, but not to glycans with a single, terminal Le(x) epitope. Polysaccharides 145-152 fucosyltransferase 4 Homo sapiens 131-135 20101628-6 2010 Increasing evidence suggests that carbohydrate structures (glycans), for example, phosphorylcholine-modified glycans or Galbeta1-4(Fucalpha1-3)GlcNAc- (Lewis X, Le(X)) containing glycans, expressed by the worms contribute to these modulating properties by their interaction with antigen presenting cells. Polysaccharides 59-66 fucosyltransferase 4 Homo sapiens 161-166 20101628-6 2010 Increasing evidence suggests that carbohydrate structures (glycans), for example, phosphorylcholine-modified glycans or Galbeta1-4(Fucalpha1-3)GlcNAc- (Lewis X, Le(X)) containing glycans, expressed by the worms contribute to these modulating properties by their interaction with antigen presenting cells. Polysaccharides 109-116 fucosyltransferase 4 Homo sapiens 161-166 20101628-6 2010 Increasing evidence suggests that carbohydrate structures (glycans), for example, phosphorylcholine-modified glycans or Galbeta1-4(Fucalpha1-3)GlcNAc- (Lewis X, Le(X)) containing glycans, expressed by the worms contribute to these modulating properties by their interaction with antigen presenting cells. Polysaccharides 109-116 fucosyltransferase 4 Homo sapiens 161-166 19805264-0 2009 Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives. Polysaccharides 57-63 fucosyltransferase 4 Homo sapiens 49-56 19805264-1 2009 Lewis X (Le(x))-containing glycans play important roles in numerous cellular processes. Polysaccharides 27-34 fucosyltransferase 4 Homo sapiens 0-7 18621756-1 2008 BACKGROUND: The glycan cell surface molecules, stage-specific embryonic antigen (SSEA)-1, -3 and -4 and tumor-rejection antigen (TRA)-1-60 and -1-81, are expressed in specific combinations by undifferentiated pluripotent cells, i.e. embryonic stem cells, induced pluripotent stem cells, embryonal carcinoma cells, primordial germ cells and embryonic germ cells. Polysaccharides 16-22 fucosyltransferase 4 Homo sapiens 47-99 28692034-2 2017 Fucosyltransferase IV (FUT4) is the key enzyme catalyzing the biosynthesis of alpha1,3-linkage fucosylated glycans carried by glycoproteins on the cell surface, such as the tumor-associated sugar antigen Lewis Y (LeY). Polysaccharides 107-114 fucosyltransferase 4 Homo sapiens 0-21 28692034-2 2017 Fucosyltransferase IV (FUT4) is the key enzyme catalyzing the biosynthesis of alpha1,3-linkage fucosylated glycans carried by glycoproteins on the cell surface, such as the tumor-associated sugar antigen Lewis Y (LeY). Polysaccharides 107-114 fucosyltransferase 4 Homo sapiens 23-27 18953356-1 2008 The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells. Polysaccharides 4-10 fucosyltransferase 4 Homo sapiens 23-27 18953356-4 2008 Flow cytometric analysis of differentiating cells together with biochemical studies using inhibitors of glycan synthesis and of sialidases showed that increased CD15 expression is not due to de novo biosynthesis of CD15, but results predominantly from induction of alpha(2-3)-sialidase activity, which yields CD15 from cell-surface sialyl-CD15 (also known as sialyl-Lewis x, sLe(x) or CD15s). Polysaccharides 104-110 fucosyltransferase 4 Homo sapiens 161-165 16282604-4 2006 Since Lex residues of pathogens bind to the C-type lectin dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) expressed on human DCs, we hypothesized that Lex glycans of CEACAM1 are recognized by DC-SIGN. Polysaccharides 169-176 fucosyltransferase 4 Homo sapiens 6-9 16282604-4 2006 Since Lex residues of pathogens bind to the C-type lectin dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) expressed on human DCs, we hypothesized that Lex glycans of CEACAM1 are recognized by DC-SIGN. Polysaccharides 169-176 fucosyltransferase 4 Homo sapiens 165-168 15845541-0 2005 Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands. Polysaccharides 94-100 fucosyltransferase 4 Homo sapiens 61-67