PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32308723-6 2020 The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property. Polysaccharides 35-50 interleukin 1 alpha Homo sapiens 125-133 2694696-0 1989 [Interleukin-1-inducing activity of the polysaccharide-containing antigens of the cell wall in Yersinia pestis]. Polysaccharides 40-54 interleukin 1 alpha Homo sapiens 1-14 2861158-0 1985 The role of serum in interleukin 1 production by human monocytes activated by endotoxins and their polysaccharide moieties. Polysaccharides 99-113 interleukin 1 alpha Homo sapiens 21-34 2861158-1 1985 Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes. Polysaccharides 4-18 interleukin 1 alpha Homo sapiens 145-158 2861158-1 1985 Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes. Polysaccharides 22-24 interleukin 1 alpha Homo sapiens 145-158 2861158-7 1985 The data presented suggest that the serum component(s) and the IL 1 inducers (LPS or PS) act in synergism by two different pathways since the two signals can be delivered sequentially. Polysaccharides 79-81 interleukin 1 alpha Homo sapiens 63-67 3494301-2 1987 When the polysaccharides were presented to the macrophages in a sterically fixed form, i.e. as microparticles, they induced the release of interleukin 1 (IL-1) from the macrophages. Polysaccharides 9-24 interleukin 1 alpha Homo sapiens 139-158 6330537-0 1984 Interleukin 1 secretion by human monocytes stimulated by the isolated polysaccharide region of the Bordetella pertussis endotoxin. Polysaccharides 70-84 interleukin 1 alpha Homo sapiens 0-13 6330537-2 1984 This polysaccharide, previously found to be a very potent, macrophage-dependent, polyclonal B-cell activator and to mediate the specific binding of the endotoxin to macrophages, stimulated the interleukin 1 (IL 1) secretion by human monocytes; its potency was similar to that measured for the endotoxin. Polysaccharides 5-19 interleukin 1 alpha Homo sapiens 193-212 6330537-3 1984 It was concluded that endotoxin-induced IL 1 production may be initiated by the interaction of the polysaccharide chain of the B. pertussis endotoxin and a specific structure present on macrophages. Polysaccharides 99-113 interleukin 1 alpha Homo sapiens 40-44 32308723-7 2020 However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential. Polysaccharides 27-42 interleukin 1 alpha Homo sapiens 95-103 17996095-3 2007 In previous studies, F3, the active component of the polysaccharide extract, was found to activate various cytokines such as IL-1, IL-6, IL-12, and TNF-alpha. Polysaccharides 53-67 interleukin 1 alpha Homo sapiens 125-129 28346799-3 2017 Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6. Polysaccharides 4-18 interleukin 1 alpha Homo sapiens 315-333 8502198-2 1993 The bacterial polysaccharides stimulate gingival neutrophils and macrophages to interleukin-1 (IL-1) production. Polysaccharides 14-29 interleukin 1 alpha Homo sapiens 80-99