PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3494301-2	1987	When the polysaccharides were presented to the macrophages in a sterically fixed form, i.e. as microparticles, they induced the release of interleukin 1 (IL-1) from the macrophages.	Polysaccharides	9-24	interleukin 1 alpha	Homo sapiens	139-158	
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	interleukin 1 alpha	Homo sapiens	95-103	
2861158-0	1985	The role of serum in interleukin 1 production by human monocytes activated by endotoxins and their polysaccharide moieties.	Polysaccharides	99-113	interleukin 1 alpha	Homo sapiens	21-34	
2861158-1	1985	Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes.	Polysaccharides	4-18	interleukin 1 alpha	Homo sapiens	145-158	
2861158-1	1985	Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes.	Polysaccharides	22-24	interleukin 1 alpha	Homo sapiens	145-158	
2861158-7	1985	The data presented suggest that the serum component(s) and the IL 1 inducers (LPS or PS) act in synergism by two different pathways since the two signals can be delivered sequentially.	Polysaccharides	79-81	interleukin 1 alpha	Homo sapiens	63-67	
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	interleukin 1 alpha	Homo sapiens	125-133	
6330537-0	1984	Interleukin 1 secretion by human monocytes stimulated by the isolated polysaccharide region of the Bordetella pertussis endotoxin.	Polysaccharides	70-84	interleukin 1 alpha	Homo sapiens	0-13	
6330537-2	1984	This polysaccharide, previously found to be a very potent, macrophage-dependent, polyclonal B-cell activator and to mediate the specific binding of the endotoxin to macrophages, stimulated the interleukin 1 (IL 1) secretion by human monocytes; its potency was similar to that measured for the endotoxin.	Polysaccharides	5-19	interleukin 1 alpha	Homo sapiens	193-212	
6330537-3	1984	It was concluded that endotoxin-induced IL 1 production may be initiated by the interaction of the polysaccharide chain of the B. pertussis endotoxin and a specific structure present on macrophages.	Polysaccharides	99-113	interleukin 1 alpha	Homo sapiens	40-44	
17996095-3	2007	In previous studies, F3, the active component of the polysaccharide extract, was found to activate various cytokines such as IL-1, IL-6, IL-12, and TNF-alpha.	Polysaccharides	53-67	interleukin 1 alpha	Homo sapiens	125-129	
28346799-3	2017	Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6.	Polysaccharides	4-18	interleukin 1 alpha	Homo sapiens	315-333	
2694696-0	1989	[Interleukin-1-inducing activity of the polysaccharide-containing antigens of the cell wall in Yersinia pestis].	Polysaccharides	40-54	interleukin 1 alpha	Homo sapiens	1-14	
8502198-2	1993	The bacterial polysaccharides stimulate gingival neutrophils and macrophages to interleukin-1 (IL-1) production.	Polysaccharides	14-29	interleukin 1 alpha	Homo sapiens	80-99