PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17145745-3 2007 So far, the glycan structure mediating the interaction of native ICAM-3 with DC-SIGN is undefined. Polysaccharides 12-18 CD209 molecule Homo sapiens 77-84 32939912-5 2020 Significant binding to DC-SIGN was also found for azido-fucosylated glycans. Polysaccharides 68-75 CD209 molecule Homo sapiens 23-30 12239306-3 2002 The presence of an additional glycan at the N-terminal base of the V2 loop of SHIV(SF162P3) gp120 compared to that of the parental virus was shown to be responsible for the increase in binding to DC-SIGN. Polysaccharides 30-36 CD209 molecule Homo sapiens 196-203 34827585-0 2021 Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study. Polysaccharides 0-6 CD209 molecule Homo sapiens 55-62 34827585-2 2021 DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a protein expressed in antigen-presenting cells that recognizes a variety of glycan epitopes. Polysaccharides 170-176 CD209 molecule Homo sapiens 0-7 34827585-2 2021 DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a protein expressed in antigen-presenting cells that recognizes a variety of glycan epitopes. Polysaccharides 170-176 CD209 molecule Homo sapiens 9-88 34827585-9 2021 Based on our findings and previously described glycoforms on the SARS-CoV-2 Spike, we predicted the potential glycan epitopes for DC-SIGN. Polysaccharides 110-116 CD209 molecule Homo sapiens 130-137 35017635-5 2022 Moreover, these fucosylated glycans can serve as ligands for DC-SIGN positive tumour-associated macrophages, modulating their activation and inducing the production of IL-10. Polysaccharides 28-35 CD209 molecule Homo sapiens 61-68 32957164-0 2020 Mono- and Di-Fucosylated Glycans of the Parasitic Worm S. mansoni are Recognized Differently by the Innate Immune Receptor DC-SIGN. Polysaccharides 25-32 CD209 molecule Homo sapiens 123-130 32957164-1 2020 The parasitic worm, Schistosoma mansoni, expresses unusual fucosylated glycans in a stage-dependent manner that can be recognized by the human innate immune receptor DC-SIGN, thereby shaping host immune responses . Polysaccharides 73-80 CD209 molecule Homo sapiens 170-177 32957164-4 2020 The molecular interaction between the synthetic glycans and DC-SIGN was studied by NMR and molecular modeling , which demonstrated that the alpha1,3-fucoside of LDN-F can coordinate with the Ca 2+ -ion of the canonical binding site of DC-SIGN allowing for additional interactions with the underlying LDN backbone. Polysaccharides 48-55 CD209 molecule Homo sapiens 60-67 32957164-4 2020 The molecular interaction between the synthetic glycans and DC-SIGN was studied by NMR and molecular modeling , which demonstrated that the alpha1,3-fucoside of LDN-F can coordinate with the Ca 2+ -ion of the canonical binding site of DC-SIGN allowing for additional interactions with the underlying LDN backbone. Polysaccharides 48-55 CD209 molecule Homo sapiens 235-242 16713984-5 2006 By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins. Polysaccharides 133-140 CD209 molecule Homo sapiens 33-40 16713984-5 2006 By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins. Polysaccharides 133-140 CD209 molecule Homo sapiens 42-93 16713984-5 2006 By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins. Polysaccharides 133-139 CD209 molecule Homo sapiens 33-40 16713984-5 2006 By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins. Polysaccharides 133-139 CD209 molecule Homo sapiens 42-93 16713984-6 2006 Moreover, we show that fluorescent beads coated with selected biotinylated glycans bind to DC-SIGN-expressing dendritic cells in vitro. Polysaccharides 75-82 CD209 molecule Homo sapiens 91-98 34880222-5 2021 We also demonstrate that DC-SIGN, unlike MR and Dectin-2, recognises planktonic P. aeruginosa cultures and this interaction depends on the presence of the common polysaccharide antigen. Polysaccharides 162-176 CD209 molecule Homo sapiens 25-32 34748320-3 2021 Using heteromultivalent liposomes copresenting mannosides bearing aromatic aglycones with natural glycan ligands, we serendipitously discovered striking cooperativity effects for DC-SIGN+ but not for Langerin+ cell lines. Polysaccharides 98-104 CD209 molecule Homo sapiens 179-186 34748320-6 2021 We further present preliminary evidence that the aglycone allosterically activates glycan recognition and thereby contributes to DC-SIGN-specific cell targeting. Polysaccharides 83-89 CD209 molecule Homo sapiens 129-136 35380569-1 2022 The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. Polysaccharides 55-62 CD209 molecule Homo sapiens 28-35 31242623-1 2019 A fluorine nuclear magnetic resonance (19F-NMR)-based method is employed to assess the binding preferences and interaction details of a library of synthetic fluorinated monosaccharides towards dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN), a lectin of biomedical interest, which is involved in different viral infections, including HIV and Ebola, and is able to recognize a variety of self- and non-self-glycans. Polysaccharides 448-455 CD209 molecule Homo sapiens 193-272 32811831-5 2020 The synthetic glycans are accurately characterized by advanced NMR and MS approaches, the 3D structures are defined, and their potent binding activity with human DC-SIGN, a receptor associated with the gut lymphoid tissue, is disclosed. Polysaccharides 14-21 CD209 molecule Homo sapiens 162-169 31489145-8 2019 Surprisingly, however, glioblastoma EVs lack glycans that could bind Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN, CD209), a receptor that mediates uptake and induction of CD4+ and CD8+ T cell activation. Polysaccharides 45-52 CD209 molecule Homo sapiens 69-148 31489145-8 2019 Surprisingly, however, glioblastoma EVs lack glycans that could bind Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN, CD209), a receptor that mediates uptake and induction of CD4+ and CD8+ T cell activation. Polysaccharides 45-52 CD209 molecule Homo sapiens 150-157 31466401-5 2019 High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively. Polysaccharides 13-20 CD209 molecule Homo sapiens 48-127 31466401-5 2019 High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively. Polysaccharides 13-20 CD209 molecule Homo sapiens 129-136 31428526-4 2019 Here we show that human luminal breast cancer (LBC) clusterin also bears terminal fucosylated glycans, conferring clusterin the ability to interact with DC-SIGN, a C-type lectin receptor expressed by myeloid cells. Polysaccharides 94-101 CD209 molecule Homo sapiens 153-160 29963041-1 2018 DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively. Polysaccharides 94-101 CD209 molecule Homo sapiens 0-7 28471403-5 2017 Flavivirus envelope proteins are N-glycosylated surface proteins, which interact with C-type lectins, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) through their glycans. Polysaccharides 206-213 CD209 molecule Homo sapiens 102-181 28824637-4 2017 These glycans interact with mannose-specific lectins, especially with dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). Polysaccharides 6-13 CD209 molecule Homo sapiens 70-149 28824637-4 2017 These glycans interact with mannose-specific lectins, especially with dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). Polysaccharides 6-13 CD209 molecule Homo sapiens 151-158 28751750-5 2017 The use of DC-SIGN mutants lacking the N-glycans as well as blocking glycan-mediated lateral interactions strongly impaired cell stiffening during pathogen binding. Polysaccharides 41-47 CD209 molecule Homo sapiens 11-18 28471403-5 2017 Flavivirus envelope proteins are N-glycosylated surface proteins, which interact with C-type lectins, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) through their glycans. Polysaccharides 206-213 CD209 molecule Homo sapiens 183-190 25030450-4 2014 Here we applied single-molecule-based approaches to directly visualize the impact of glycan-based interactions on the spatiotemporal organization and interaction with clathrin of the glycosylated pathogen recognition receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN). Polysaccharides 85-91 CD209 molecule Homo sapiens 226-304 25656175-0 2015 Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens. Polysaccharides 93-99 CD209 molecule Homo sapiens 40-47 27554335-3 2016 The aim of this study is to explore the role of DC-SIGN in capturing and processing glycan-containing allergens and in the subsequent DC activation and T helper cell polarization in AD patients. Polysaccharides 84-90 CD209 molecule Homo sapiens 48-55 26976925-0 2016 Human DC-SIGN binds specific human milk glycans. Polysaccharides 40-47 CD209 molecule Homo sapiens 6-13 26976925-4 2016 Unexpectedly, DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) showed robust binding to many HMGs, whereas other C-type lectins failed to bind, and Siglec-5 and Siglec-9 showed weak binding to a few glycans. Polysaccharides 228-235 CD209 molecule Homo sapiens 14-81 26976925-4 2016 Unexpectedly, DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) showed robust binding to many HMGs, whereas other C-type lectins failed to bind, and Siglec-5 and Siglec-9 showed weak binding to a few glycans. Polysaccharides 228-235 CD209 molecule Homo sapiens 83-90 26976925-7 2016 Binding of DC-SIGN to the simple HMGs 2"-fucosyl-lactose (2"-FL) and 3-fucosyl-lactose (3-FL) was confirmed by flow cytometry to beads conjugated with 2"-FL or 3-FL, as well as the ability of the free glycans to inhibit DC-SIGN binding. Polysaccharides 201-208 CD209 molecule Homo sapiens 11-18 26985831-8 2016 These glycans on the pili are recognized by human dendritic cells via the C-type lectin receptor DC-SIGN, a key carbohydrate-dependent immune tailoring pattern recognition receptor. Polysaccharides 6-13 CD209 molecule Homo sapiens 97-104 25885805-3 2015 Here we show using a human skin explant model that the in situ targeting of antigens to DC-SIGN using glycan-modified liposomes enhances the antigen-presenting capacity of CD14(+) dDCs. Polysaccharides 102-108 CD209 molecule Homo sapiens 88-95 25885805-4 2015 Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses. Polysaccharides 73-79 CD209 molecule Homo sapiens 55-62 25030450-4 2014 Here we applied single-molecule-based approaches to directly visualize the impact of glycan-based interactions on the spatiotemporal organization and interaction with clathrin of the glycosylated pathogen recognition receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN). Polysaccharides 85-91 CD209 molecule Homo sapiens 306-313 24239607-2 2014 Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is one of the best-studied C-type lectin receptors expressed on DCs and its glycan specificity and functional requirements for ligand binding have been intensively investigated. Polysaccharides 166-172 CD209 molecule Homo sapiens 0-79 24239607-5 2014 Our results clearly demonstrate that DC-SIGN has a broader glycan specificity compared to DCIR, which interacts only with mannotriose, sulfo-Lewis(a), Lewis(b) and Lewis(a). Polysaccharides 59-65 CD209 molecule Homo sapiens 37-44 24239607-2 2014 Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is one of the best-studied C-type lectin receptors expressed on DCs and its glycan specificity and functional requirements for ligand binding have been intensively investigated. Polysaccharides 166-172 CD209 molecule Homo sapiens 81-88 19249311-1 2009 Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface. Polysaccharides 23-30 CD209 molecule Homo sapiens 84-91 21540232-0 2011 Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin. Polysaccharides 54-61 CD209 molecule Homo sapiens 94-101 21540232-2 2011 DC-SIGN interacts with glycan structures on HIV-1, facilitating virus survival, transmission and infection, whereas Langerin, which is characteristic of Langerhans cells (LCs), promotes HIV-1 uptake and degradation. Polysaccharides 23-29 CD209 molecule Homo sapiens 0-7 21650186-1 2011 Force-distance measurements have been used to examine differences in the interaction of the dendritic cell glycan-binding receptor DC-SIGN and the closely related endothelial cell receptor DC-SIGNR (L-SIGN) with membranes bearing glycan ligands. Polysaccharides 107-113 CD209 molecule Homo sapiens 131-138 23291968-6 2013 DC-SIGN recognizes specific glycans on HIV-1 and this interaction can be blocked by competitive inhibition through glycans. Polysaccharides 28-35 CD209 molecule Homo sapiens 0-7 23291968-6 2013 DC-SIGN recognizes specific glycans on HIV-1 and this interaction can be blocked by competitive inhibition through glycans. Polysaccharides 115-122 CD209 molecule Homo sapiens 0-7 21371544-0 2011 DC-SIGN mediated antigen-targeting using glycan-modified liposomes: formulation considerations. Polysaccharides 41-47 CD209 molecule Homo sapiens 0-7 21515679-7 2011 Furthermore, we found that the alpha1-3,4-fucose moieties of Le glycans expressed on DC-SIGN-binding Mac-2BP were important for recognition. Polysaccharides 64-71 CD209 molecule Homo sapiens 85-92 21515679-9 2011 Importantly, Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues from certain parts of patients in comparison with CEA from other parts, suggesting that DC-SIGN-binding Mac-2BP bearing tumor-associated Le glycans may become a novel potential colorectal cancer biomarker for some patients instead of CEA. Polysaccharides 258-265 CD209 molecule Homo sapiens 206-213 20034698-0 2010 DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools. Polysaccharides 22-29 CD209 molecule Homo sapiens 0-7 19249311-1 2009 Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface. Polysaccharides 23-30 CD209 molecule Homo sapiens 93-98 19230080-5 2009 Lewis antigen glycans, present in human milk, bind to DC-SIGN and inhibit HIV-1 transfer to CD4 + T lymphocytes. Polysaccharides 14-21 CD209 molecule Homo sapiens 54-61 19230080-9 2009 Identifying the specific milk oligosaccharides that interact with DC-SIGN may guide the development of glycan-based drugs that prevent transmission of HIV-1 and other pathogens that use DC-SIGN as an entry point. Polysaccharides 103-109 CD209 molecule Homo sapiens 66-73 19230080-9 2009 Identifying the specific milk oligosaccharides that interact with DC-SIGN may guide the development of glycan-based drugs that prevent transmission of HIV-1 and other pathogens that use DC-SIGN as an entry point. Polysaccharides 103-109 CD209 molecule Homo sapiens 186-193 18292560-0 2008 Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells. Polysaccharides 101-108 CD209 molecule Homo sapiens 54-61 18292560-2 2008 DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is one of the major C-type lectins expressed on DCs and exhibits high affinity for nonsialylated Lewis (Le) glycans. Polysaccharides 185-192 CD209 molecule Homo sapiens 0-66 18292560-2 2008 DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is one of the major C-type lectins expressed on DCs and exhibits high affinity for nonsialylated Lewis (Le) glycans. Polysaccharides 185-192 CD209 molecule Homo sapiens 68-75 18292560-6 2008 DC-SIGN ligands containing Lea/Leb glycans are also highly expressed on primary cancer colon epithelia but not on normal colon epithelia, and DC-SIGN is suggested to be involved in the association between DCs and colorectal cancer cells in situ by DC-SIGN recognizing these cancer-related Le glycan ligands. Polysaccharides 35-42 CD209 molecule Homo sapiens 0-7 18292560-6 2008 DC-SIGN ligands containing Lea/Leb glycans are also highly expressed on primary cancer colon epithelia but not on normal colon epithelia, and DC-SIGN is suggested to be involved in the association between DCs and colorectal cancer cells in situ by DC-SIGN recognizing these cancer-related Le glycan ligands. Polysaccharides 35-41 CD209 molecule Homo sapiens 0-7