PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33723432-5	2021	By-passing DHODH inhibition via uridine supplementation decreases SC assembly by altering mitochondrial phospholipid composition, specifically elevated peroxisomal-derived ether phospholipids.	Uridine	32-39	dihydroorotate dehydrogenase (quinone)	Homo sapiens	11-16	
15547088-8	2004	Incubation of cells with LEF-M and uridine in addition to LEF-M reversed the inhibition of migration, suggesting that the observed effects were due to DHODH inhibition.	Uridine	35-42	dihydroorotate dehydrogenase (quinone)	Homo sapiens	151-156	
33201894-9	2020	Importantly, the addition of exogenous uridine, which reconstitutes the cellular pool of pyrimidine by the salvage pathway, to the culture media recovered the impaired rDNA transcription, nucleolar morphology, p53 levels, and proliferation of glioblastoma cells caused by the DHODH inhibitors.	Uridine	39-46	dihydroorotate dehydrogenase (quinone)	Homo sapiens	276-281	
24772329-6	2014	Here, we show that apoptosis in human colon carcinoma cells induced by the mitochondrial respiratory chain complex III inhibition can be prevented by supplementation with uridine or orotate (products of the reaction catalyzed by DHODH) rather than with dihydroorotate (a DHODH substrate).	Uridine	171-178	dihydroorotate dehydrogenase (quinone)	Homo sapiens	271-276	
21355448-1	2011	Dihydroorotate dehydrogenase (DHODH), a novel and recently discovered enzyme, is involved in the biosynthesis of uridine.	Uridine	113-120	dihydroorotate dehydrogenase (quinone)	Homo sapiens	0-28	
21355448-1	2011	Dihydroorotate dehydrogenase (DHODH), a novel and recently discovered enzyme, is involved in the biosynthesis of uridine.	Uridine	113-120	dihydroorotate dehydrogenase (quinone)	Homo sapiens	30-35	
30459406-7	2018	Interestingly, exogenous uridine or orotate, the latter being a metabolite of the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH), abolished the antiviral activity of AR-12 and its derivatives.	Uridine	25-32	dihydroorotate dehydrogenase (quinone)	Homo sapiens	133-138	
30663496-4	2018	We further characterized the mechanism of DHO-DH enzyme inhibition while in blood samples of patients entered into Phase II studies we evaluated DHO-DH inhibition in WBC and plasma uridine depletion.	Uridine	181-188	dihydroorotate dehydrogenase (quinone)	Homo sapiens	145-151	
30663496-6	2018	In the Phase II study depending on the dose (600 to 2000 mg/m2), uridine decreased to 20% (at the highest dose) or to 80-85% (at the middle dose) or did not change, which was associated with inhibition of DHO-DH (1% activity left vs 11 and 24% left).	Uridine	65-72	dihydroorotate dehydrogenase (quinone)	Homo sapiens	205-211	
34462431-6	2021	Furthermore, we obtain evidence suggesting that serum uridine is a key factor in determining the efficacy of therapeutic agents that target DHODH.	Uridine	54-61	dihydroorotate dehydrogenase (quinone)	Homo sapiens	140-145	
34462431-7	2021	In the presence of physiological concentrations of uridine, neuroblastoma cell lines are highly resistant to DHODH inhibition.	Uridine	51-58	dihydroorotate dehydrogenase (quinone)	Homo sapiens	109-114	
34462431-8	2021	This uridine-dependent resistance to DHODH inhibitors can be abrogated by dipyridamole, an FDA-approved drug that blocks nucleoside transport.	Uridine	5-12	dihydroorotate dehydrogenase (quinone)	Homo sapiens	37-42	
34442810-6	2021	Then, the antiviral activity of MEDS433 was reversed by the addition of exogenous uridine or the product of hDHODH, the orotate, thus confirming hDHODH as the specific target of MEDS433 in hCoVs-infected cells.	Uridine	82-89	dihydroorotate dehydrogenase (quinone)	Homo sapiens	145-151