PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
516531-2	1979	Simultaneously, activity of the key enzymes, participating in metabolism of orotic acid and of uridine, was measured: OMP-pyrophosphorylase /EC 2.4.2.10, orotidine-5"-phosphate: purophosphate phosphorybosyl transferase/ and uridine kinase /EC 2.7.1.48, ATP: uridine-5"-phosphotransferase/.	Uridine	95-102	uridine-cytidine kinase 2	Homo sapiens	224-238	
31420268-3	2019	The pyrimidine salvage enzyme uridine-cytidine kinase 2 (UCK2), a ~29 kDa protein that forms a tetramer in its active state, is necessary for uridine salvage.	Uridine	30-37	uridine-cytidine kinase 2	Homo sapiens	57-61	
195585-1	1977	Uridine kinase, the rate-limiting enzyme in the activation (phosphorylation) of uridine and the corresponding chemotherapeutic analogues, is present as two isoenzymes localized exclusively in the cytosol of rapidly growing neoplasms, including the S-37 sarcoma, EL-4 leukaemia, HeLa cells (a human carcinoma) and the Novikoff hepatoma.	Uridine	80-87	uridine-cytidine kinase 2	Homo sapiens	0-14	
195585-4	1977	During the development of tumour-cell resistance to 5-fluorouracil or 5-fluorouridine in vivo there was an early differential increase in the activity of a low-affinity (high-Km) uridine kinase isoenzyme, as measured in cell extracts, and a 7-fold increase in the Km values for the uptake of both uridine and 5-fluorouridine into the intact resistant cells.	Uridine	78-85	uridine-cytidine kinase 2	Homo sapiens	179-193	
30551402-5	2019	UCK2 is responsible for the phosphorylation of uridine and cytidine to their corresponding monophosphate in a salvage pathway of pyrimidine nucleotides biosynthesis.	Uridine	47-54	uridine-cytidine kinase 2	Homo sapiens	0-4	
28955773-1	2017	Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine.	Uridine	111-118	uridine-cytidine kinase 2	Homo sapiens	47-51	
30304569-1	2019	Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP).	Uridine	92-99	uridine-cytidine kinase 2	Homo sapiens	54-58	
28955773-5	2017	Replacement of His117 in human UCK2, corresponding to residue Tyr93 in ttCK, by Tyr resulted in a loss of uridine phosphorylation activity.	Uridine	106-113	uridine-cytidine kinase 2	Homo sapiens	31-35	
27906629-3	2016	The Vmax of purified recombinant UCK2 was 22- and 8-fold higher with uridine and cytidine, respectively, compared to those observed for the purified recombinant UCK1 enzyme.	Uridine	69-76	uridine-cytidine kinase 2	Homo sapiens	33-37	
19532987-4	2009	We have investigated the mechanism of human uridine-cytidine kinase 2 (UCK2, EC 2.7.1.48), which catalyzes the transfer of a phosphate group from ATP to the ribose 5"-hydroxyl of cytidine and uridine.	Uridine	44-51	uridine-cytidine kinase 2	Homo sapiens	71-75	
27239701-4	2016	Transient and stable overexpression of UCK2 in neuroblastoma cells increased the metabolism of uridine and cytidine as well as the cytotoxicity of 3-deazauridine.	Uridine	95-102	uridine-cytidine kinase 2	Homo sapiens	39-43	
27239701-5	2016	Knockdown of endogenous UCK2 as well as overexpression of UCK1 resulted in decreased metabolism of uridine and cytidine and protected the neuroblastoma cells from 3-deazauridine-induced toxicity.	Uridine	99-106	uridine-cytidine kinase 2	Homo sapiens	24-28	
20641989-12	2004	Phosphorylation of uridine and cytosine is 15-20 times faster with UCK2 than with UCK1.	Uridine	19-26	uridine-cytidine kinase 2	Homo sapiens	67-71	
15735337-2	2005	UCK2 catalyzes the phosphorylation of the natural ribonucleosides cytidine and uridine to cytidine 5"-monophosphate (CMP) and uridine 5"-monophosphate (UMP), respectively, and activates several important frontline antimetabolite drugs.	Uridine	79-86	uridine-cytidine kinase 2	Homo sapiens	0-4	
2161304-8	1990	Plasma uridine concentration was significantly higher in 11 hypertensive patients on minoxidil compared with pretreatment values, suggesting that uridine kinase inhibition is of a degree sufficient to increase the circulating pool of uridine.	Uridine	7-14	uridine-cytidine kinase 2	Homo sapiens	146-160	
9799561-0	1998	Uridine kinase: altered enzyme with decreased affinities for uridine and CTP.	Uridine	61-68	uridine-cytidine kinase 2	Homo sapiens	0-14	
9799561-1	1998	Uridine kinase is the rate-limiting enzyme in the salvage pathway for uridine or cytidine of mammalian cells.	Uridine	70-77	uridine-cytidine kinase 2	Homo sapiens	0-14