PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19494110-7	2009	In mNect.hCNT3-expressing cells (but not under negative control conditions) the rate of acidification increased in media containing 0.5 mm uridine, providing the first direct evidence for H(+)-coupled uridine transport.	Uridine	139-146	solute carrier family 28 member 3	Homo sapiens	9-14	
25923048-5	2015	Both fluorescence microscopy and flow cytometry experiments showed that uridine-furan uptake was better suited for distinguishing cells that express hCNT1 or hCNT3.	Uridine	72-79	solute carrier family 28 member 3	Homo sapiens	158-163	
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Uridine	235-242	solute carrier family 28 member 3	Homo sapiens	248-253	
20495821-5	2010	Apparent affinity of hCNT3 for uridine in H(+) was insensitive to membrane voltage at negative potentials, and decreased with depolarization.	Uridine	31-38	solute carrier family 28 member 3	Homo sapiens	21-26	
20495821-10	2010	The different effects of uridine and inosine on presteady-state currents in H(+) indicated a change in rate-limiting step for the transport of these substrates by H(+)-coupled hCNT3.	Uridine	25-32	solute carrier family 28 member 3	Homo sapiens	176-181	
19494110-7	2009	In mNect.hCNT3-expressing cells (but not under negative control conditions) the rate of acidification increased in media containing 0.5 mm uridine, providing the first direct evidence for H(+)-coupled uridine transport.	Uridine	201-208	solute carrier family 28 member 3	Homo sapiens	9-14	
18344610-9	2008	mRNAs of nucleoside transporter (NT), ENT1, ENT2, CNT, and CNT3 were expressed in neutrophils; and their inhibitors, inosine, uridine, and s-(4-nitrobenzyl)-6-thioinosine, reduced the [Ca(2+)](i) rise induced by beta-NAD(+) and fMLP.	Uridine	126-133	solute carrier family 28 member 3	Homo sapiens	59-63	
18199742-6	2008	Access of this membrane-impermeant probe to Cys-561, as determined by inhibition of hCNT3 transport activity, required H(+), but not Na(+), and was blocked by extracellular uridine.	Uridine	173-180	solute carrier family 28 member 3	Homo sapiens	84-89	
17453413-7	2007	Only hCNT3 was also able to couple transport of uridine to uptake of H(+).	Uridine	48-55	solute carrier family 28 member 3	Homo sapiens	5-10	
15955867-2	2005	In this study, the sensitivity of a high-throughput yeast expression system used previously for hCNT1 and hCNT3 was improved and used to characterize determinants for interaction of uridine (Urd) with hCNT2.	Uridine	182-189	solute carrier family 28 member 3	Homo sapiens	106-111	
16271041-2	2006	To understand its uridine binding and translocation mechanisms, a cysteine-less version of hCNT3 was constructed and used for cysteine-accessibility and permeant-protection assays.	Uridine	18-25	solute carrier family 28 member 3	Homo sapiens	91-96	
15955867-2	2005	In this study, the sensitivity of a high-throughput yeast expression system used previously for hCNT1 and hCNT3 was improved and used to characterize determinants for interaction of uridine (Urd) with hCNT2.	Uridine	191-194	solute carrier family 28 member 3	Homo sapiens	106-111	
11396613-5	2001	hCNT3 and mCNT3 have primary structures that place them in a CNT subfamily separate from CNT1/2, transport a wide range of physiological pyrimidine and purine nucleosides and antineoplastic and antiviral nucleoside drugs (system cib), and exhibit a Na+:uridine coupling ratio of at least 2:1 (cf 1:1 for hCNT1/2).	Uridine	253-260	solute carrier family 28 member 3	Homo sapiens	0-5	
15861042-4	2005	Kinetic studies were undertaken in yeast with a high through-put semi-automated assay process; reference hCNT3 exhibited Km values of 1.7+/-0.3, 3.6+/-1.3, 2.2+/-0.7, and 2.1+/-0.6 muM and Vmax values of 1402+/-286, 1310+/-113, 1020+/-44, and 1740+/-114 pmol/mg/min, respectively, for uridine, cytidine, adenosine and inosine.	Uridine	285-292	solute carrier family 28 member 3	Homo sapiens	105-110	
15861042-6	2005	All of the characterized hCNT3 variants produced in oocytes retained sodium and proton dependence of uridine transport based on measurements of radioisotope flux and two-electrode voltage-clamp studies.	Uridine	101-108	solute carrier family 28 member 3	Homo sapiens	25-30	
14645682-4	2003	hCNT1 and hCNT3 recognized uridine through distinguishable binding motifs.	Uridine	27-34	solute carrier family 28 member 3	Homo sapiens	10-15	
14645682-7	2003	The changes of binding energy between transporter proteins and different uridine analogs suggested that hCNT1 formed hydrogen bonds (H-bonds) with C(3")-OH, C(5")-OH, or N(3)-H of uridine, but not with C(2")-OH, whereas hCNT3 formed H-bonds to C(3")-OH, but not to N(3)-H, C(5")-OH, and C(2")-OH.	Uridine	73-80	solute carrier family 28 member 3	Homo sapiens	220-225	
14645682-7	2003	The changes of binding energy between transporter proteins and different uridine analogs suggested that hCNT1 formed hydrogen bonds (H-bonds) with C(3")-OH, C(5")-OH, or N(3)-H of uridine, but not with C(2")-OH, whereas hCNT3 formed H-bonds to C(3")-OH, but not to N(3)-H, C(5")-OH, and C(2")-OH.	Uridine	180-187	solute carrier family 28 member 3	Homo sapiens	220-225	
11032837-7	2001	hCNT3 was electrogenic, and a sigmoidal dependence of uridine influx on Na(+) concentration indicated a Na(+):uridine coupling ratio of at least 2:1 for both hCNT3 and mCNT3 (cf 1:1 for hCNT1/2).	Uridine	110-117	solute carrier family 28 member 3	Homo sapiens	158-163