PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10864042-2 2000 Genetic depletion of yeast Gar1p, an essential common component of H/ACA snoRNPs, leads to inhibition of uridine isomerizations to pseudo-uridines on the 35S pre-rRNA and of the early pre-rRNA cleavages at sites A1 and A2, resulting in a loss of mature 18S rRNA synthesis. Uridine 105-112 H/ACA snoRNP pseudouridylase subunit GAR1 Saccharomyces cerevisiae S288C 27-32