PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18252807-2	2008	This study investigated whether oltipraz and a novel class of 1,2-dithiole-3-thiones were capable of preventing insulin resistance induced by hyperosmotic stress, thereby enhancing insulin-dependent signals, and, if so, whether the restoration of insulin signal was mediated with the inhibition of S6K1 activity stimulated by hyperosmotic stress.	1,2-dithiol-3-thione	62-84	insulin	Homo sapiens	112-119	
18945820-2	2009	Oltipraz and other novel 1,2-dithiole-3-thione congeners have the capability to prevent insulin resistance via AMP-activated protein kinase (AMPK) activation.	1,2-dithiol-3-thione	25-46	insulin	Homo sapiens	88-95	
18252807-8	2008	A variety of synthetic 1,2-dithiole-3-thione derivatives also inhibited S6K1 activity and insulin resistance induced by hyperosmotic stress in HepG2 cells.	1,2-dithiol-3-thione	23-44	insulin	Homo sapiens	90-97	
18252807-9	2008	The results of this study demonstrate that a novel class of 1,2-dithiole-3-thiones improve insulin sensitivity under the condition of hyperosmotic stress, which results from the inhibition of S6K1 activation.	1,2-dithiol-3-thione	60-82	insulin	Homo sapiens	91-98	
18252807-2	2008	This study investigated whether oltipraz and a novel class of 1,2-dithiole-3-thiones were capable of preventing insulin resistance induced by hyperosmotic stress, thereby enhancing insulin-dependent signals, and, if so, whether the restoration of insulin signal was mediated with the inhibition of S6K1 activity stimulated by hyperosmotic stress.	1,2-dithiol-3-thione	62-84	insulin	Homo sapiens	181-188	
18252807-2	2008	This study investigated whether oltipraz and a novel class of 1,2-dithiole-3-thiones were capable of preventing insulin resistance induced by hyperosmotic stress, thereby enhancing insulin-dependent signals, and, if so, whether the restoration of insulin signal was mediated with the inhibition of S6K1 activity stimulated by hyperosmotic stress.	1,2-dithiol-3-thione	62-84	insulin	Homo sapiens	181-188