PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Methimazole 17-28 thyroid peroxidase Rattus norvegicus 68-86 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Methimazole 17-28 thyroid peroxidase Rattus norvegicus 88-91 34757178-0 2022 Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring. Methimazole 53-64 thyroid peroxidase Rattus norvegicus 26-41 6861708-1 1983 We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide. Methimazole 97-125 thyroid peroxidase Rattus norvegicus 147-165 2691880-12 1989 Finally, methimazole and phorbol 12-myristate 13-acetate show different effects on TSH-induced increases in thyroglobulin and thyroid peroxidase mRNA levels. Methimazole 9-20 thyroid peroxidase Rattus norvegicus 126-144 2535809-1 1989 We previously described an in vitro incubation system for studying the mechanism of inhibition of thyroid peroxidase (TPO)-catalyzed iodination by the antithyroid drug 1-methyl-2-mercaptoimidazole (MMI). Methimazole 168-196 thyroid peroxidase Rattus norvegicus 118-121 2535809-1 1989 We previously described an in vitro incubation system for studying the mechanism of inhibition of thyroid peroxidase (TPO)-catalyzed iodination by the antithyroid drug 1-methyl-2-mercaptoimidazole (MMI). Methimazole 198-201 thyroid peroxidase Rattus norvegicus 118-121 6861708-1 1983 We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide. Methimazole 97-125 thyroid peroxidase Rattus norvegicus 167-170 6861708-1 1983 We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide. Methimazole 127-130 thyroid peroxidase Rattus norvegicus 147-165 6861708-1 1983 We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide. Methimazole 127-130 thyroid peroxidase Rattus norvegicus 167-170 436767-1 1979 Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination. Methimazole 10-33 thyroid peroxidase Rattus norvegicus 97-115 436767-1 1979 Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination. Methimazole 10-33 thyroid peroxidase Rattus norvegicus 117-120 744122-1 1978 A reinvestigation of the mechanism of action of methylmercaptoimidazole, propylthiouracil, and thiouracil on thyroid peroxidase (TPO) was undertaken. Methimazole 48-71 thyroid peroxidase Rattus norvegicus 129-132 744122-2 1978 A preliminary incubation of TPO and H2O2 with methylmercaptoimidazole, propylthiouracil, or thiouracil was carried out in the absence of oxidizable substrates (i.e. I- or guaiacol). Methimazole 46-69 thyroid peroxidase Rattus norvegicus 28-31 947933-9 1976 TPO activities in the thyroid homogenate of rats to which MMI (2 mg per rat) or PTU (10 mg per rat) had been administered intraperitoneally were determined before and after dialysis against buffer. Methimazole 58-61 thyroid peroxidase Rattus norvegicus 0-3