PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2535809-1	1989	We previously described an in vitro incubation system for studying the mechanism of inhibition of thyroid peroxidase (TPO)-catalyzed iodination by the antithyroid drug 1-methyl-2-mercaptoimidazole (MMI).	Methimazole	168-196	thyroid peroxidase	Rattus norvegicus	118-121	
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Methimazole	17-28	thyroid peroxidase	Rattus norvegicus	68-86	
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Methimazole	17-28	thyroid peroxidase	Rattus norvegicus	88-91	
2691880-12	1989	Finally, methimazole and phorbol 12-myristate 13-acetate show different effects on TSH-induced increases in thyroglobulin and thyroid peroxidase mRNA levels.	Methimazole	9-20	thyroid peroxidase	Rattus norvegicus	126-144	
34757178-0	2022	Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.	Methimazole	53-64	thyroid peroxidase	Rattus norvegicus	26-41	
2535809-1	1989	We previously described an in vitro incubation system for studying the mechanism of inhibition of thyroid peroxidase (TPO)-catalyzed iodination by the antithyroid drug 1-methyl-2-mercaptoimidazole (MMI).	Methimazole	198-201	thyroid peroxidase	Rattus norvegicus	118-121	
947933-9	1976	TPO activities in the thyroid homogenate of rats to which MMI (2 mg per rat) or PTU (10 mg per rat) had been administered intraperitoneally were determined before and after dialysis  against buffer.	Methimazole	58-61	thyroid peroxidase	Rattus norvegicus	0-3	
436767-1	1979	Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination.	Methimazole	10-33	thyroid peroxidase	Rattus norvegicus	97-115	
436767-1	1979	Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination.	Methimazole	10-33	thyroid peroxidase	Rattus norvegicus	117-120	
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Methimazole	97-125	thyroid peroxidase	Rattus norvegicus	147-165	
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Methimazole	97-125	thyroid peroxidase	Rattus norvegicus	167-170	
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Methimazole	127-130	thyroid peroxidase	Rattus norvegicus	147-165	
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Methimazole	127-130	thyroid peroxidase	Rattus norvegicus	167-170	
744122-1	1978	A reinvestigation of the mechanism of action of methylmercaptoimidazole, propylthiouracil, and thiouracil on thyroid peroxidase (TPO) was undertaken.	Methimazole	48-71	thyroid peroxidase	Rattus norvegicus	129-132	
744122-2	1978	A preliminary incubation of TPO and H2O2 with methylmercaptoimidazole, propylthiouracil, or thiouracil was carried out in the absence of oxidizable substrates (i.e. I- or guaiacol).	Methimazole	46-69	thyroid peroxidase	Rattus norvegicus	28-31