PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16045903-1	2005	Reduction of naphthoquinones by DT-diaphorase is often described as a detoxification reaction.	Naphthoquinones	13-28	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	32-45	
16045903-7	2005	It is not possible to generalize with regard to the effects of modulation of tissue levels of DT-diaphorase on naphthoquinone toxicity in vivo, since this may change not only the severity of the toxic effects, but also the target organ specificity.	Naphthoquinones	111-125	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	94-107	
10654840-5	1999	A similar order of activity was recorded in the relative ability of these substances to increase hepatic activities of DT-diaphorase, consistent with a role for this enzyme in facilitating conjugation and excretion of this naphthoquinone.	Naphthoquinones	223-237	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	119-132	
11248224-8	2001	Modulation of DT-diaphorase activity in animals may therefore not only alter the severity of naphthoquinone toxicity, but also cause pronounced changes in the site of toxic action of these substances.	Naphthoquinones	93-107	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	14-27	
11248224-9	2001	The factors that may control whether induction of DT-diaphorase in animals will decrease or increase naphthoquinone toxicity are discussed.	Naphthoquinones	101-115	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	50-63	
10654840-10	1999	The results of the present experiments show that modulation of tissue levels of DT-diaphorase may not only alter the severity of naphthoquinone toxicity in vivo, but may also change the relative toxicity of these substances to different target organs.	Naphthoquinones	129-143	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	80-93	
6200119-5	1984	The toxicity of 1-naphthol and the naphthoquinones was potentiated by dicoumarol, an inhibitor of DT-diaphorase (NAD(P)H:quinone oxidoreductase).	Naphthoquinones	35-50	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	98-111	
10190578-6	1999	The results of the present experiment suggest that activation of 2-hydroxy-1,4-naphthoquinone by DT-diaphorase may also occur in vivo and show that increased tissue levels of DT-diaphorase are not always associated with naphthoquinone detoxification.	Naphthoquinones	79-93	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	97-110	
10190578-6	1999	The results of the present experiment suggest that activation of 2-hydroxy-1,4-naphthoquinone by DT-diaphorase may also occur in vivo and show that increased tissue levels of DT-diaphorase are not always associated with naphthoquinone detoxification.	Naphthoquinones	79-93	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	175-188