PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31466259-8	2019	Here we provide an overview of the anti-AML activities of naphthoquinone derivatives, as well as analysis of their mechanism of action, including induction of reduction-oxidation imbalance, alteration in mitochondrial transmembrane potential, Bcl-2 modulation, initiation of DNA damage, and modulation of MAPK and STAT3 activity, alterations in the unfolded protein response and translocation of FOX-related transcription factors to the nucleus.	Naphthoquinones	58-72	signal transducer and activator of transcription 3	Homo sapiens	314-319	
32044231-0	2020	STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae.	Naphthoquinones	29-44	signal transducer and activator of transcription 3	Homo sapiens	0-5	
32044231-3	2020	In this study, we evaluated representative naphthoquinones isolated from T. avellanedae and found that furanonaphthoquinones were the key structures required to exhibit STAT3 phosphorylation inhibitory activities.	Naphthoquinones	43-58	signal transducer and activator of transcription 3	Homo sapiens	169-174	
30003778-0	2018	Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells.	Naphthoquinones	42-57	signal transducer and activator of transcription 3	Homo sapiens	61-66	
30003778-5	2018	In addition, drug affinity responsive target stability assays were performed to validate a direct interaction of the naphthoquinones with STAT3.	Naphthoquinones	117-132	signal transducer and activator of transcription 3	Homo sapiens	138-143