PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33466332-4 2021 In particular, cholinesterases (ChEs), beta-amyloid (Abeta) and tau proteins have been identified as key targets of these classes of compounds, where the NQ or AQ scaffold may contribute to the biological effect against AD as main unit or significant substructure. Naphthoquinones 154-156 amyloid beta precursor protein Homo sapiens 39-59 23259849-0 2013 Methylations of tryptophan-modified naphthoquinone affect its inhibitory potential toward Abeta aggregation. Naphthoquinones 36-50 amyloid beta precursor protein Homo sapiens 90-95 31282646-5 2019 Combining experimental and computational approaches, we demonstrated the anti-amyloidogenic effect of naphthoquinone-tryptophan-based hybrid molecules toward PHF6 (tau-derived aggregative peptide), Amyloid beta (Abeta42), and human islet amyloid polypeptide (hIAPP) implicated in AD and T2DM, respectively. Naphthoquinones 102-116 amyloid beta precursor protein Homo sapiens 198-210