PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16876345-1 2006 It has been previously reported that beta-cyclodextrin (beta-CD) enhances the oral absorption of the pentavalent antimony (Sb) drug, meglumine antimoniate (MA). Antimony 123-125 beta-carotene oxygenase 1 Mus musculus 56-63 17656054-1 2008 The composition comprising the highly water-soluble drug meglumine antimoniate (MA) and beta-cyclodextrin (beta-CD) was shown previously to enhance the absorption of Sb by oral route and render MA orally active in a murine model of cutaneous leishmaniasis. Antimony 166-168 beta-carotene oxygenase 1 Mus musculus 107-114 17656054-2 2008 This unexpected behaviour was attributed, in part, to the fact that the heating of equimolar mixture of MA and beta-CD (first step of preparation of MA/beta-CD composition) induced the depolymerization of MA from high-molecular weight Sb complexes into 1:1 Sb-meglumine complex, resulting in an enhanced oral bioavailability of Sb. Antimony 235-237 beta-carotene oxygenase 1 Mus musculus 111-118 17656054-2 2008 This unexpected behaviour was attributed, in part, to the fact that the heating of equimolar mixture of MA and beta-CD (first step of preparation of MA/beta-CD composition) induced the depolymerization of MA from high-molecular weight Sb complexes into 1:1 Sb-meglumine complex, resulting in an enhanced oral bioavailability of Sb. Antimony 235-237 beta-carotene oxygenase 1 Mus musculus 152-159 17656054-2 2008 This unexpected behaviour was attributed, in part, to the fact that the heating of equimolar mixture of MA and beta-CD (first step of preparation of MA/beta-CD composition) induced the depolymerization of MA from high-molecular weight Sb complexes into 1:1 Sb-meglumine complex, resulting in an enhanced oral bioavailability of Sb. Antimony 257-259 beta-carotene oxygenase 1 Mus musculus 111-118 17656054-2 2008 This unexpected behaviour was attributed, in part, to the fact that the heating of equimolar mixture of MA and beta-CD (first step of preparation of MA/beta-CD composition) induced the depolymerization of MA from high-molecular weight Sb complexes into 1:1 Sb-meglumine complex, resulting in an enhanced oral bioavailability of Sb. Antimony 257-259 beta-carotene oxygenase 1 Mus musculus 152-159 17656054-7 2008 A model is proposed for the mechanisms involved in the enhanced absorption of Sb from the MA/beta-CD composition. Antimony 78-80 beta-carotene oxygenase 1 Mus musculus 93-100 16876345-5 2006 When MA solution was heated for 48 h at 55 degrees C to mimic the conditions used to prepare MA/beta-CD, MA was found to suffer dissociation, from high molecular weight Sb complexes into species of lower molecular weight. Antimony 169-171 beta-carotene oxygenase 1 Mus musculus 96-103 16876345-7 2006 In vitro skin permeation experiments using MA and MA/beta-CD indicated a two-fold increase in the Sb flux for MA/beta-CD. Antimony 98-100 beta-carotene oxygenase 1 Mus musculus 53-60 16876345-7 2006 In vitro skin permeation experiments using MA and MA/beta-CD indicated a two-fold increase in the Sb flux for MA/beta-CD. Antimony 98-100 beta-carotene oxygenase 1 Mus musculus 113-120