PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28686070-0 2018 Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Rifampin 21-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-93 29143479-1 2018 Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 94-110 29143479-1 2018 Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 112-119 29143479-1 2018 Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Rifampin 10-13 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 94-110 29143479-1 2018 Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Rifampin 10-13 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 112-119 27795624-2 2016 Rifampicin, a first-line antitubercular therapy (ATT) drug, is a potent inducer of hepatic cytochrome P450 (CYP). Rifampin 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 91-106 29357810-5 2018 mRNA expression levels and enzyme activities of CYP1A2, CYP2B6, and CYP3A in HepaRG cells treated with prototypical inducers of each CYP isoform [omeprazole (OME) for CYP1A2, phenobarbital (PB) for CYP2B6, and rifampicin (RIF) for CYP3A] were evaluated. Rifampin 210-220 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-51 29357810-5 2018 mRNA expression levels and enzyme activities of CYP1A2, CYP2B6, and CYP3A in HepaRG cells treated with prototypical inducers of each CYP isoform [omeprazole (OME) for CYP1A2, phenobarbital (PB) for CYP2B6, and rifampicin (RIF) for CYP3A] were evaluated. Rifampin 222-225 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-51 28215634-8 2017 We have confirmed that the hepatocyte-like cells prepared by our methods were able to increase gene expression of cytochrome P450 enzymes upon encountering rifampicin, phenobarbital, or omeprazole. Rifampin 156-166 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 114-129 28173639-0 2017 Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes. Rifampin 13-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-82 28173639-3 2017 In this study, the effects of bosentan and rifampin on the expression and activities of organic anion-transporting peptide (OATP) and cytochrome P450 (CYP450) 2C9 and CYP3A4 were investigated in vitro. Rifampin 43-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 134-149 28173639-3 2017 In this study, the effects of bosentan and rifampin on the expression and activities of organic anion-transporting peptide (OATP) and cytochrome P450 (CYP450) 2C9 and CYP3A4 were investigated in vitro. Rifampin 43-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-157 28173639-7 2017 These results confirm rifampin- and bosentan-induced interactions between OATP transporters and CYP450. Rifampin 22-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 96-102 27458223-2 2016 Three studies were conducted to evaluate the potential drug-drug interactions between delamanid and antiretroviral drugs, including ritonavir, a strong inhibitor of CYP3A4, and selected anti-TB drugs, including rifampin, a strong inducer of cytochrome P450 (CYP) isozymes. Rifampin 211-219 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 241-256 27795624-2 2016 Rifampicin, a first-line antitubercular therapy (ATT) drug, is a potent inducer of hepatic cytochrome P450 (CYP). Rifampin 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-111 27795624-3 2016 There is potential for pharmacokinetic interaction between rifampicin and anti-hypertensives that are CYP substrates: amlodipine and metoprolol. Rifampin 59-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 102-105 23974699-0 2013 Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method. Rifampin 25-35 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-70 25808545-6 2015 Differentiated cells produce albumin and apolipoprotein B100 at levels equivalent to primary human hepatocytes, while demonstrating an 8-fold induction of CYP450 activity in response to aryl hydrocarbon receptor (AhR) agonist omeprazole and a 10-fold induction in response to PXR agonist rifampicin. Rifampin 288-298 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 155-161 24060875-1 2013 Rifampin is a potent inducer of cytochrome P450 (CYP) enzymes and transporters. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 32-47 24060875-1 2013 Rifampin is a potent inducer of cytochrome P450 (CYP) enzymes and transporters. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-52 23770199-5 2013 In primary human hepatocytes, clopidogrel (10 and 100 muM) was cytotoxic only after cytochrome P450 (CYP) induction by rifampicin. Rifampin 119-129 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-99 23770199-5 2013 In primary human hepatocytes, clopidogrel (10 and 100 muM) was cytotoxic only after cytochrome P450 (CYP) induction by rifampicin. Rifampin 119-129 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-104 23851904-0 2013 GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin. Rifampin 93-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-54 23851904-4 2013 Twelve healthy subjects were orally administered 600 mg of rifampicin a day for 7 days, and their CYP enzyme activity was evaluated. Rifampin 59-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-101 22676424-3 2012 We examined the effect rifampicin, a well-known inducer of many cytochrome P450 (CYP) enzymes and transporters, on the pharmacokinetics of intravenous and oral S-ketamine in healthy volunteers. Rifampin 23-33 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-79 23071008-1 2013 Induction of the cytochrome P450 (CYP) family of enzymes by coadministered compounds can result in drug-drug interactions, as in the case of the coadministration of rifampicin with many CYP3A substrates, including midazolam. Rifampin 165-175 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-32 23071008-1 2013 Induction of the cytochrome P450 (CYP) family of enzymes by coadministered compounds can result in drug-drug interactions, as in the case of the coadministration of rifampicin with many CYP3A substrates, including midazolam. Rifampin 165-175 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-37 22834478-6 2012 Whereas positive controls (100 microM omeprazole and 10 microM rifampin) caused the anticipated CYP induction, the highest concentration of mirabegron (10 microM; 37 times plasma C(max)) had minimal effect on CYP1A2 and CYP3A4/5 activity, and CYP1A2 and CYP3A4 mRNA levels in freshly isolated human hepatocytes, suggesting that mirabegron is not an inducer of these enzymes. Rifampin 63-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 96-99 22676424-3 2012 We examined the effect rifampicin, a well-known inducer of many cytochrome P450 (CYP) enzymes and transporters, on the pharmacokinetics of intravenous and oral S-ketamine in healthy volunteers. Rifampin 23-33 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 81-84 22617226-0 2012 Effects of CYP induction by rifampicin on tamoxifen exposure. Rifampin 28-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 11-14 22617226-3 2012 We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. Rifampin 63-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 22617226-3 2012 We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. Rifampin 63-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-48 22617226-3 2012 We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. Rifampin 165-175 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 22617226-3 2012 We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. Rifampin 165-175 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-48 21210720-11 2011 Drug-induced cytochrome P450 gene expression was increased with rifampicin induction. Rifampin 64-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-28 21508826-4 2011 The aim of this study was to investigate the effect of CYP enzyme induction by rifampicin on the pharmacokinetics of S-ketamine and its major metabolite, S-norketamine, in healthy volunteers. Rifampin 79-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-58 22236925-1 2012 A study was carried out to establish the relative contribution of human cytochrome P450 (CYP450) enzymes in the metabolism of rifampicin (RMP), rifapentine (RPT) and rifabutin (RFB). Rifampin 126-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 22236925-1 2012 A study was carried out to establish the relative contribution of human cytochrome P450 (CYP450) enzymes in the metabolism of rifampicin (RMP), rifapentine (RPT) and rifabutin (RFB). Rifampin 126-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-95 22236925-1 2012 A study was carried out to establish the relative contribution of human cytochrome P450 (CYP450) enzymes in the metabolism of rifampicin (RMP), rifapentine (RPT) and rifabutin (RFB). Rifampin 138-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 22236925-1 2012 A study was carried out to establish the relative contribution of human cytochrome P450 (CYP450) enzymes in the metabolism of rifampicin (RMP), rifapentine (RPT) and rifabutin (RFB). Rifampin 138-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-95 17381666-0 2007 Rifampin, a cytochrome P450 3A inducer, decreases plasma concentrations of antipsychotic risperidone in healthy volunteers. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-27 19468476-11 2008 Rifampicin has to be avoided in allograft recipients as it activates cytochrome-P450 enzymes and thereby decreases the therapeutic levels of cyclosporine and prednisolone. Rifampin 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-84 21047828-1 2011 BACKGROUND: rifampicin lowers nevirapine plasma concentrations by inducing cytochrome P450. Rifampin 12-22 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-90 17181373-5 2006 For example, protease inhibitors often must be avoided if the potent CYP inducer rifampicin is co-administered. Rifampin 81-91 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-72 9871429-1 1998 BACKGROUND: Rifampin (INN, rifampicin) is a potent inducer of cytochrome P450 (CYP) enzymes involved in drug metabolism and therefore causes many drug interactions. Rifampin 12-20 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-77 16003296-1 2005 The tuberculostatic compound rifampin (INN, rifampicin) induces the expression of a number of drug metabolism-related genes involved in multidrug resistance (P-glycoprotein and multidrug resistance proteins 1 and 2), cytochromes (cytochrome P450 [CYP] 3A4), uridine diphosphate-glucuronosyltransferases, monoamine oxidases, and glutathione S -transferases. Rifampin 29-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 230-255 16003296-1 2005 The tuberculostatic compound rifampin (INN, rifampicin) induces the expression of a number of drug metabolism-related genes involved in multidrug resistance (P-glycoprotein and multidrug resistance proteins 1 and 2), cytochromes (cytochrome P450 [CYP] 3A4), uridine diphosphate-glucuronosyltransferases, monoamine oxidases, and glutathione S -transferases. Rifampin 44-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 230-255 15554232-2 2004 Upon application of this method to patients receiving different kinds of drug therapy, Herbert Remmer was the first to describe that total human hepatic cytochrome P450 was markedly elevated by the new anti-tuberculosis drug rifampicin. Rifampin 225-235 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 153-168 14604466-2 2003 The possibility of cytochrome p450 (CYP) induction by bupropion (10 microM) was evaluated in-vitro by comparing catalytic activity, immunoreactive protein and CYP mRNA levels from human hepatocytes in primary culture versus cells treated with vehicle (0.5% methanol) and with rifampicin (rifampin) as a positive control. Rifampin 276-286 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-34 14604466-2 2003 The possibility of cytochrome p450 (CYP) induction by bupropion (10 microM) was evaluated in-vitro by comparing catalytic activity, immunoreactive protein and CYP mRNA levels from human hepatocytes in primary culture versus cells treated with vehicle (0.5% methanol) and with rifampicin (rifampin) as a positive control. Rifampin 276-286 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-39 14604466-2 2003 The possibility of cytochrome p450 (CYP) induction by bupropion (10 microM) was evaluated in-vitro by comparing catalytic activity, immunoreactive protein and CYP mRNA levels from human hepatocytes in primary culture versus cells treated with vehicle (0.5% methanol) and with rifampicin (rifampin) as a positive control. Rifampin 288-296 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-34 14604466-2 2003 The possibility of cytochrome p450 (CYP) induction by bupropion (10 microM) was evaluated in-vitro by comparing catalytic activity, immunoreactive protein and CYP mRNA levels from human hepatocytes in primary culture versus cells treated with vehicle (0.5% methanol) and with rifampicin (rifampin) as a positive control. Rifampin 288-296 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-39 12426514-3 2002 Rifampin (INN, rifampicin), a potent enzyme inducer of CYP-mediated metabolism (especially CYP2C9, CYP2C19, and CYP3A4), is known to markedly decrease plasma concentrations and effects of a number coadministered drugs. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-58 12426514-3 2002 Rifampin (INN, rifampicin), a potent enzyme inducer of CYP-mediated metabolism (especially CYP2C9, CYP2C19, and CYP3A4), is known to markedly decrease plasma concentrations and effects of a number coadministered drugs. Rifampin 15-25 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-58 11744607-0 2002 Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. Rifampin 92-100 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 11601668-5 2001 However, potent inducers of CYP, such as rifampin, may decrease rofecoxib concentrations because of induction of general hepatic metabolic activity. Rifampin 41-49 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-31 11180018-1 2000 BACKGROUND: Rifampin (rifampicin) is a potent inducer of several cytochrome P450 (CYP) enzymes, including CYP3A4. Rifampin 12-20 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-80 11180018-1 2000 BACKGROUND: Rifampin (rifampicin) is a potent inducer of several cytochrome P450 (CYP) enzymes, including CYP3A4. Rifampin 12-20 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-85 11180018-1 2000 BACKGROUND: Rifampin (rifampicin) is a potent inducer of several cytochrome P450 (CYP) enzymes, including CYP3A4. Rifampin 22-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-80 11180018-1 2000 BACKGROUND: Rifampin (rifampicin) is a potent inducer of several cytochrome P450 (CYP) enzymes, including CYP3A4. Rifampin 22-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-85 14748817-1 2004 AIMS: Previous work has shown that rifampicin, a potent inducer of several cytochrome P450 (CYP) enzymes and transporters, decreased the plasma concentrations of simvastatin acid by more than 90%. Rifampin 35-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-90 14748817-1 2004 AIMS: Previous work has shown that rifampicin, a potent inducer of several cytochrome P450 (CYP) enzymes and transporters, decreased the plasma concentrations of simvastatin acid by more than 90%. Rifampin 35-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 92-95 11327199-6 2001 Concomitant use of CYP inducers, such as rifampicin (rifampin), rifabutin, phenytoin, phenobarbital or carbamazepine, should be avoided since delavirdine plasma concentrations are significantly lowered. Rifampin 41-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-22 11327199-6 2001 Concomitant use of CYP inducers, such as rifampicin (rifampin), rifabutin, phenytoin, phenobarbital or carbamazepine, should be avoided since delavirdine plasma concentrations are significantly lowered. Rifampin 53-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-22 9871429-1 1998 BACKGROUND: Rifampin (INN, rifampicin) is a potent inducer of cytochrome P450 (CYP) enzymes involved in drug metabolism and therefore causes many drug interactions. Rifampin 12-20 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-82 9871429-1 1998 BACKGROUND: Rifampin (INN, rifampicin) is a potent inducer of cytochrome P450 (CYP) enzymes involved in drug metabolism and therefore causes many drug interactions. Rifampin 27-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-77 9871429-1 1998 BACKGROUND: Rifampin (INN, rifampicin) is a potent inducer of cytochrome P450 (CYP) enzymes involved in drug metabolism and therefore causes many drug interactions. Rifampin 27-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-82 9454825-7 1998 The observed changes in the activity and protein levels of CYP1A2 and CYP3A4 correlated with a reduction in the specific messenger RNA levels both in control, 3-methylcholanthrene-treated (for CYP1A2) and rifampicin-treated (for CYP3A4) hepatocytes, which thus suggested that HGF could down-regulate CYP expression at a pretranslational level. Rifampin 205-215 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-62 9353130-14 1997 These results demonstrate that rat and human hepatocytes preserve the major forms of CYP isozymes and phase II activities and respond to inducing drugs such as rifampicin. Rifampin 160-170 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-88 9385296-1 1997 Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 32-48 9391787-0 1997 Relationship between cytochrome P-450 induction by rifampicin, hepatic volume and portal blood flow in man. Rifampin 51-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-37 9391787-10 1997 CONCLUSION: A fourfold increase of urinary 6-beta-hydroxycortisol output after induction of cytochrome P-450 by rifampicin is associated with a significant but less than 10% increase in human liver volume. Rifampin 112-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 92-108 8049635-2 1994 Debrisoquine metabolism is controlled by a cytochrome P-450 isozyme encoded at the CYP2D6 locus, which is inducible by antipyrine and rifampicin. Rifampin 134-144 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-59 7636727-2 1995 We report the effect of a known cytochrome P450 (CYP) inducer, rifampicin, on the metabolism of lidocaine by primary human hepatocytes. Rifampin 63-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 32-47 7636727-2 1995 We report the effect of a known cytochrome P450 (CYP) inducer, rifampicin, on the metabolism of lidocaine by primary human hepatocytes. Rifampin 63-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-52 7636727-3 1995 Rifampicin has been shown to induce CYP3A4, a major human hepatic CYP isozyme that is known to metabolize lidocaine to its primary metabolite, monoethylglycinexylidide. Rifampin 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-39 1974199-5 1990 Only pretreatment of rabbits with rifampicin, which induces cytochrome P-450 form 3c (P-450IIIA6), significantly increased the microsomal hydroxylation of tolbutamide. Rifampin 34-44 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 60-76 2200675-1 1990 Hepatocytes from adult and newborn humans were put into primary culture and exposed to phenobarbital, 3-methylcholanthrene, or rifampicin, three well-known inducers of cytochrome P-450 in animals. Rifampin 127-137 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 168-184 2565211-2 1989 Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily. Rifampin 39-49 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-88 34143391-8 2021 The simulations of CYP inducers predicted that the strongest interaction would occur with rifampin, with the AUC decreasing to 0.36 of the control value, whereas the simulations of CYP inhibitors predicted that the greatest effect would occur with fluconazole, with a 1.43-fold increase in AUC. Rifampin 90-98 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-22 2682943-3 1989 Rifampin and perhaps nafcillin induce cytochrome P-450-dependent isoenzyme metabolism of cyclosporine. Rifampin 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 38-54 2744145-2 1989 The use of GABA under induction of cytochrome P-450 of the liver by phenobarbital or rifampicin was not followed by immunodepression. Rifampin 85-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-51 3665337-6 1987 Based on formation clearance values estimated for 6-, 7-, and 8-hydroxywarfarin, rifampin appears to increase the clearance of the parent drug by induction of the cytochrome P-450 isozyme(s) responsible for aromatic hydroxylation. Rifampin 81-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 163-179 3608348-5 1987 Therefore rifampin preferentially affects norantipyrine or desmethyl- and 3-hydroxydiazepam metabolic formation, suggesting induction of different (iso)zymes of cytochrome P-450. Rifampin 10-18 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-177 140033-4 1977 Rifampicin seems to be a potent inducer of drug metabolism in humans and it causes a proliferation of the smooth endoplasmatic reticulum and an increase of cytochrome P450 content in the liver. Rifampin 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 156-171 33547469-4 2021 As absorption of temsavir is not altered with increased gastric pH, patients may take acid suppressive agents such as famotidine during fostemsavir therapy.Temsavir is primarily metabolized through hydrolysis but also via cytochrome P-450 (CYP) oxidation; therefore, coadministration of fostemsavir with strong CYP3A inducers such as rifampin, carbamazepine, phenytoin, mitotane, enzalutamide, or St John"s wort is contraindicated because it may result in significantly lower temsavir exposure, which can ultimately impair virologic response. Rifampin 334-342 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 222-238 6508979-5 1984 Rifampicin seems to induce preferentially the cytochrome P-450 (iso-) enzyme(s) involved in the demethylation of antipyrine to norantipyrine. Rifampin 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-62 1233229-5 1975 The acceleration of oestrogen hydroxylation by rifampicin was paralleled by an increase in microsomal cytochrome P-450, and also by microsomal reduction of rifampicin-quinone, a reactive metabolite of rifampicin. Rifampin 47-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 102-118 31656654-3 2019 The cytochrome P450 (CYP) enzyme inducer, rifampicin, and the CYP inhibitor, clarithromycin, have clinical activity against MAC and key drugs in the treatment of MAC infection. Rifampin 42-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24