PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23981033-4 2013 The lactam series has improved chemical and metabolic stability relative to our previously reported pyrazoloketone series, while retaining potent inhibition of ACC1 and ACC2. Lactams 4-10 acetyl-CoA carboxylase beta Homo sapiens 169-173