PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22116304-7 2012 Immunoblot assays indicated that hypoxia and L-mimosine stabilized hypoxia-inducible factor-1alpha (HIF-1alpha) and induced Btg2 and Ndrg1 protein expression, but downregulated protein levels of cyclin A in both PC-3 and LNCaP cells. Mimosine 45-55 cyclin A2 Homo sapiens 195-203 7628532-8 1995 For example, treatment with mimosine, which arrests cells in G1 with 2C DNA, resulted in cyclin A accumulating to mitotic levels, whereas cyclin B remained at a low concentration, the first time this phenomenon has been observed. Mimosine 28-36 cyclin A2 Homo sapiens 89-97 8502485-5 1993 Pharmacological blockade with mimosine was utilized to further delineate cyclin A expression and to distinguish the temporal induction from the mechanisms of enzyme activation. Mimosine 30-38 cyclin A2 Homo sapiens 73-81 1386764-4 1992 Furthermore, cells synchronized in late G1 by exposure to the drug mimosine contain active cyclin A/p34 CDC2 kinase, indicating that p34 CDC2 activation can occur before DNA synthesis begins. Mimosine 67-75 cyclin A2 Homo sapiens 91-99 8940249-5 1996 After release from mimosine treatment, 84% of the cell population remained in G1 up to 8 h. Treating breast cancer cells with 400 microM mimosine for 24 h inhibited cyclin E- and cyclin A-associated kinase activity by 85% or more, although immunoblots using anti-cyclin A, cyclin E, cdc2, and cdk2 antibodies showed that these key subunits were still present in the cells at pretreatment levels. Mimosine 137-145 cyclin A2 Homo sapiens 179-187 8940249-5 1996 After release from mimosine treatment, 84% of the cell population remained in G1 up to 8 h. Treating breast cancer cells with 400 microM mimosine for 24 h inhibited cyclin E- and cyclin A-associated kinase activity by 85% or more, although immunoblots using anti-cyclin A, cyclin E, cdc2, and cdk2 antibodies showed that these key subunits were still present in the cells at pretreatment levels. Mimosine 137-145 cyclin A2 Homo sapiens 263-271