PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32410856-6 2020 In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator. Lycopene 79-87 tumor necrosis factor Homo sapiens 199-208 30512227-8 2019 Finally, lycopene isomers restore the TNF-alpha-blunted uptake of glucose by adipocytes via a modulation of AKT phosphorylation. Lycopene 9-17 tumor necrosis factor Homo sapiens 38-47 32328606-4 2020 At the same time, lycopene treatment elevated the mRNA expression levels of tnfalpha, tgfbeta and hif1alpha in beta cells. Lycopene 18-26 tumor necrosis factor Homo sapiens 76-84 27155396-9 2016 KEY FINDINGS: Lycopene could reduce TNF-alpha-induced monocyte adhesion and H2O2- induced cell damage in RPE cells. Lycopene 14-22 tumor necrosis factor Homo sapiens 36-45 28386381-8 2017 RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P < 0.05). Lycopene 31-39 tumor necrosis factor Homo sapiens 72-81 28386381-11 2017 CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells. Lycopene 13-21 tumor necrosis factor Homo sapiens 122-131 28440398-4 2017 We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level. Lycopene 20-28 tumor necrosis factor Homo sapiens 54-81 28440398-4 2017 We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level. Lycopene 20-28 tumor necrosis factor Homo sapiens 83-91 28440398-6 2017 In TNFalpha-stimulated endothelial cells, nuclear factor-kappaB (NF-kappaB) nuclear translocation and transcriptional activity were abolished by up to 12 h of lycopene pre-treatment. Lycopene 159-167 tumor necrosis factor Homo sapiens 3-11 28440398-11 2017 Therefore, the findings of the present study indicate that lycopene suppresses the activation of TNFalpha-induced signaling pathways through the upregulation of Nrf2-mediated HO-1 expression. Lycopene 59-67 tumor necrosis factor Homo sapiens 97-105 27609268-10 2016 Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma. Lycopene 13-21 tumor necrosis factor Homo sapiens 138-147 26779636-5 2016 Concomitant with this, immunofluorescence staining of lycopene-treated cells showed a significant suppression (>=25 %) of TNF-induced NF-kappaB p65 subunit nuclear translocation. Lycopene 54-62 tumor necrosis factor Homo sapiens 125-128 27155396-10 2016 Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-kappaB activation for up to 12h in TNFalpha-treated RPE cells. Lycopene 13-21 tumor necrosis factor Homo sapiens 101-109 27155396-12 2016 The use of Nrf2 siRNA blocks the inhibitory effect of lycopene in TNF-alpha-induced ICAM-1 expression and NF-kappaB activation. Lycopene 54-62 tumor necrosis factor Homo sapiens 66-75 27155396-15 2016 Following lycopene treatment, TNF-alpha-induced ROS production was abolished. Lycopene 10-18 tumor necrosis factor Homo sapiens 30-39 22152988-3 2012 The objective of the present study was to investigate whether lycopene and beta-carotene in micelles (M), at concentrations that could be reached via the diet (10-25 mug/ml) could aid in the reduction of TNF-alpha plus IL-1beta-induced inflammation of Caco-2 human epithelial cells. Lycopene 62-70 tumor necrosis factor Homo sapiens 204-213 24891766-5 2014 The extent of the effect of lycopene is dependent on the proinflammtory stimulus (PMA, LPS or TNF) used. Lycopene 28-36 tumor necrosis factor Homo sapiens 94-97 22429818-6 2012 Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells. Lycopene 0-8 tumor necrosis factor Homo sapiens 100-121 22429818-6 2012 Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells. Lycopene 0-8 tumor necrosis factor Homo sapiens 123-126 21487789-5 2011 Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4). Lycopene 30-38 tumor necrosis factor Homo sapiens 97-106 22648619-0 2012 Lycopene attenuates LPS-induced TNF-alpha secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media. Lycopene 0-8 tumor necrosis factor Homo sapiens 32-41 22648619-3 2012 Because lycopene possesses anti-inflammatory properties, we hypothesize that lycopene could reduce the production of TNF-alpha by macrophages and thus interfere in the cross-talk between macrophages and adipocytes. Lycopene 8-16 tumor necrosis factor Homo sapiens 117-126 22648619-3 2012 Because lycopene possesses anti-inflammatory properties, we hypothesize that lycopene could reduce the production of TNF-alpha by macrophages and thus interfere in the cross-talk between macrophages and adipocytes. Lycopene 77-85 tumor necrosis factor Homo sapiens 117-126 22648619-4 2012 METHODS AND RESULTS: We demonstrated that physiological concentrations of lycopene were able to attenuate the lipopolysaccharide (LPS)-mediated induction of TNF-alpha in RAW 264.7 macrophages, at both the mRNA and protein levels. Lycopene 74-82 tumor necrosis factor Homo sapiens 157-166 22162208-0 2012 beta-Carotene and lycopene affect endothelial response to TNF-alpha reducing nitro-oxidative stress and interaction with monocytes. Lycopene 18-26 tumor necrosis factor Homo sapiens 58-67 21487789-5 2011 Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4). Lycopene 30-38 tumor necrosis factor Homo sapiens 68-95 21487789-6 2011 CONCLUSION: These findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-kappaB, CD14 and TLR4 expression and production of TNF-alpha, thereby endorsing its usefulness as therapy for vascular inflammatory diseases. Lycopene 40-48 tumor necrosis factor Homo sapiens 241-250 18439578-0 2008 Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Lycopene 0-8 tumor necrosis factor Homo sapiens 18-27 20952175-6 2011 In both preadipocytes and differentiated 3T3-L1 adipocytes, lycopene preincubation for 24 h decreased the TNFalpha-mediated induction of IL-6 and MCP-1. Lycopene 60-68 tumor necrosis factor Homo sapiens 106-114 20952175-9 2011 In transient transfections, a decrease of the luciferase gene reporter under control of NF-kappaB responsive element was observed for cells incubated in the presence of lycopene and TNFalpha compared to TNFalpha alone. Lycopene 169-177 tumor necrosis factor Homo sapiens 203-211 20676966-4 2010 The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses. Lycopene 24-32 tumor necrosis factor Homo sapiens 74-82 18439578-10 2008 Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases. Lycopene 65-73 tumor necrosis factor Homo sapiens 93-102 18439578-10 2008 Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases. Lycopene 230-238 tumor necrosis factor Homo sapiens 93-102 18439578-10 2008 Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases. Lycopene 230-238 tumor necrosis factor Homo sapiens 93-102 18439578-4 2008 In the present study, we studied the effect of lycopene on TNF-alpha-induced signaling in human umbilical endothelial cells (HUVECs). Lycopene 47-55 tumor necrosis factor Homo sapiens 59-68 18439578-5 2008 We found that TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression in HUVECs was inhibited by lycopene, whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule (PECAM-1) expression were not affected. Lycopene 113-121 tumor necrosis factor Homo sapiens 14-23 18439578-6 2008 A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus. Lycopene 34-42 tumor necrosis factor Homo sapiens 54-63 18439578-7 2008 In line with this, TNF-alpha-induced NF-kappaB-DNA but not AP1-DNA complexes formation was inhibited by lycopene, as determined by the electrophoretic mobility shift assay (EMSA). Lycopene 104-112 tumor necrosis factor Homo sapiens 19-28 18389438-6 2008 Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected. Lycopene 0-8 tumor necrosis factor Homo sapiens 59-67