PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	tumor necrosis factor	Mus musculus	158-185	
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	tumor necrosis factor	Mus musculus	110-137	
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	tumor necrosis factor	Mus musculus	139-148	
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	tumor necrosis factor	Mus musculus	187-196	
25689917-9	2015	The immunohistochemical experiment exhibited that lycopene intake contributed to attenuation of nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) expressions in kidney tissue.	Lycopene	50-58	tumor necrosis factor	Mus musculus	135-162	
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	tumor necrosis factor	Mus musculus	81-108	
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	tumor necrosis factor	Mus musculus	110-119	
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	tumor necrosis factor	Mus musculus	81-108	
29475907-8	2018	LPS-stimulated Cox2, Nos2 and Tnfa gene expression was inhibited by 50 muM beta-carotene and lycopene, and by 0.5-1% TBB.	Lycopene	93-101	tumor necrosis factor	Mus musculus	30-34	
28651168-14	2017	There was an increase in the levels of tumor necrosis factor-alpha, interferon-gamma and interleukin-10 after exposure to CS, and these effects were suppressed by both doses of lycopene.	Lycopene	177-185	tumor necrosis factor	Mus musculus	39-66	
27357536-10	2016	The expression of the proinflammatory factors TNF-alpha and NF-kB increased markedly 48 h after SCI, and their upregulation was significantly attenuated by lycopene treatment.	Lycopene	156-164	tumor necrosis factor	Mus musculus	46-55	
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	tumor necrosis factor	Mus musculus	110-119	
28472825-5	2017	We found that Lycopene notably prevented the increase of IL-1beta, TNFalpha and CRP levels in mice fed HFD.	Lycopene	14-22	tumor necrosis factor	Mus musculus	67-75	
25689917-9	2015	The immunohistochemical experiment exhibited that lycopene intake contributed to attenuation of nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) expressions in kidney tissue.	Lycopene	50-58	tumor necrosis factor	Mus musculus	164-173	
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	tumor necrosis factor	Mus musculus	72-81	
19693648-3	2010	RESULTS: Lycopene inhibited LPS-induced production of nitric oxide (NO) and interleukin-6 (IL-6) with decreased mRNAs of inducible nitric oxide synthase and IL-6 but had no effect on TNF-alpha.	Lycopene	9-17	tumor necrosis factor	Mus musculus	183-192	
18055235-3	2008	The aim of the present study was to explore the antinociceptive effect of lycopene and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.	Lycopene	74-82	tumor necrosis factor	Mus musculus	131-140	
18055235-7	2008	Lycopene also inhibited the TNF-alpha and NO release in a dose dependent manner.	Lycopene	0-8	tumor necrosis factor	Mus musculus	28-37	
18055235-8	2008	These results indicate an antinociceptive activity of lycopene possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.	Lycopene	54-62	tumor necrosis factor	Mus musculus	112-121