PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35533600-0 2022 Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 102-105 34311540-6 2021 The effect mechanisms of lycopene are related to the regulation of several signal transduction pathways, such as PI3K/Akt pathway, modulation of insulin-like growth factors system, the suppression of activity of sex steroid hormones, the modification of relevant gene expression, and the alteration of mitochondrial function. Lycopene 25-33 AKT serine/threonine kinase 1 Homo sapiens 118-121 35533600-6 2022 In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect. Lycopene 216-224 AKT serine/threonine kinase 1 Homo sapiens 33-36 35533600-6 2022 In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect. Lycopene 216-224 AKT serine/threonine kinase 1 Homo sapiens 241-244 35533600-8 2022 These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC. Lycopene 77-85 AKT serine/threonine kinase 1 Homo sapiens 179-182 35533600-8 2022 These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC. Lycopene 147-155 AKT serine/threonine kinase 1 Homo sapiens 179-182 35164673-0 2022 Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma. Lycopene 69-77 AKT serine/threonine kinase 1 Homo sapiens 87-90 35164673-13 2022 CONCLUSION: Taken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC. Lycopene 106-114 AKT serine/threonine kinase 1 Homo sapiens 124-127 32606612-0 2020 Lycopene Inhibits Epithelial-Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 99-102 32765784-0 2020 Lycopene attenuates high glucose-mediated apoptosis in MPC5 podocytes by promoting autophagy via the PI3K/AKT signaling pathway. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 106-109 28585698-0 2018 Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 130-133 32297350-8 2020 Lycopene also inhibited activation of Akt in response to LPA and EGF as assessed by immunoblotting. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 38-41 28585698-8 2018 Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene. Lycopene 50-58 AKT serine/threonine kinase 1 Homo sapiens 18-21 28585698-8 2018 Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene. Lycopene 50-58 AKT serine/threonine kinase 1 Homo sapiens 210-213 28585698-9 2018 In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling. Lycopene 70-78 AKT serine/threonine kinase 1 Homo sapiens 31-34 28585698-9 2018 In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling. Lycopene 155-163 AKT serine/threonine kinase 1 Homo sapiens 31-34 28585698-10 2018 Taken together, our findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis. Lycopene 150-158 AKT serine/threonine kinase 1 Homo sapiens 57-60 23483004-6 2013 Proteins that were most affected by lycopene were those involved in antioxidant responses, cytoprotection, apoptosis, growth inhibition, androgen receptor signaling, and the Akt/mTOR cascade. Lycopene 36-44 AKT serine/threonine kinase 1 Homo sapiens 174-177 24397737-7 2014 In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL. Lycopene 26-34 AKT serine/threonine kinase 1 Homo sapiens 68-71 24851879-0 2014 The effect of lycopene on the PI3K/Akt signalling pathway in prostate cancer. Lycopene 14-22 AKT serine/threonine kinase 1 Homo sapiens 35-38 24851879-8 2014 In this review, the effect of lycopene on PI3K/Akt pathway is summarised, which could be one of major mechanisms for anti-cancer activity of lycopene. Lycopene 30-38 AKT serine/threonine kinase 1 Homo sapiens 47-50 24851879-8 2014 In this review, the effect of lycopene on PI3K/Akt pathway is summarised, which could be one of major mechanisms for anti-cancer activity of lycopene. Lycopene 141-149 AKT serine/threonine kinase 1 Homo sapiens 47-50 25932745-8 2015 Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression. Lycopene 12-20 AKT serine/threonine kinase 1 Homo sapiens 139-142 19664603-0 2009 Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 99-102 22707264-0 2012 Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 117-120 22707264-6 2012 Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K. Lycopene 10-18 AKT serine/threonine kinase 1 Homo sapiens 137-140 22707264-8 2012 The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways. Lycopene 32-40 AKT serine/threonine kinase 1 Homo sapiens 113-116 21923160-9 2011 Lycopene could effectively inhibit the phosphorylation of Akt, glycogen synthase kinase-3beta (GSK-3beta) and ERK 1/2 proteins. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 58-61 19664603-6 2009 Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 161-164 19664603-8 2009 Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation. Lycopene 45-53 AKT serine/threonine kinase 1 Homo sapiens 128-131 18708285-14 2009 The inhibitory effects of lycopene and EPA on cell proliferation of human colon cancer HT-29 cells were, in part, associated with the down-regulation of the PI-3K/Akt/mTOR signaling pathway. Lycopene 26-34 AKT serine/threonine kinase 1 Homo sapiens 163-166 18537129-12 2008 In conclusion, lycopene inhibited cell proliferation of human colon cancer cells via suppression of the Akt signaling pathway and downstream targeted molecules. Lycopene 15-23 AKT serine/threonine kinase 1 Homo sapiens 104-107 18537129-0 2008 Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 76-79 18537129-6 2008 Thus we investigated the inhibitory effects of lycopene on the Akt signaling pathway in human colon cancer HT-29 cells. Lycopene 47-55 AKT serine/threonine kinase 1 Homo sapiens 63-66 18537129-8 2008 Lycopene treatment suppressed Akt activation and non-phosphorylated beta-catenin protein level in human colon cancer cells. Lycopene 0-8 AKT serine/threonine kinase 1 Homo sapiens 30-33 18283040-11 2008 In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3. Lycopene 15-23 AKT serine/threonine kinase 1 Homo sapiens 312-315