PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18439578-0	2008	Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.	Lycopene	0-8	intercellular adhesion molecule 1	Homo sapiens	48-54	
18439578-10	2008	Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases.	Lycopene	65-73	intercellular adhesion molecule 1	Homo sapiens	133-139	
18439578-5	2008	We found that TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression in HUVECs was inhibited by lycopene, whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule (PECAM-1) expression were not affected.	Lycopene	113-121	intercellular adhesion molecule 1	Homo sapiens	32-65	
18439578-5	2008	We found that TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression in HUVECs was inhibited by lycopene, whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule (PECAM-1) expression were not affected.	Lycopene	113-121	intercellular adhesion molecule 1	Homo sapiens	67-73	
10856518-10	2000	Pre-treatment with beta-carotene, lutein and lycopene significantly reduced the expression of ICAM-1 by 11, 14, and 18%, respectively.	Lycopene	45-53	intercellular adhesion molecule 1	Homo sapiens	94-100	
28440398-4	2017	We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level.	Lycopene	20-28	intercellular adhesion molecule 1	Homo sapiens	168-206	
28440398-4	2017	We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level.	Lycopene	20-28	intercellular adhesion molecule 1	Homo sapiens	208-214	
28440398-9	2017	The use of siRNA targeting HO-1 blocked the inhibitory effects of lycopene on IkappaB degradation and ICAM-1 expression.	Lycopene	66-74	intercellular adhesion molecule 1	Homo sapiens	102-108	
27155396-0	2016	Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells.	Lycopene	0-8	intercellular adhesion molecule 1	Homo sapiens	18-24	
27155396-10	2016	Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-kappaB activation for up to 12h in TNFalpha-treated RPE cells.	Lycopene	13-21	intercellular adhesion molecule 1	Homo sapiens	31-37	
27155396-12	2016	The use of Nrf2 siRNA blocks the inhibitory effect of lycopene in TNF-alpha-induced ICAM-1 expression and NF-kappaB activation.	Lycopene	54-62	intercellular adhesion molecule 1	Homo sapiens	84-90