PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30409612-4	2019	When lycopene was paired with the methoxylated anthocyanins, the anti-inflammatory effect on the inhibition of the cytokine IL-8, which is a pro-inflammatory biomarker, was increased by 15-69% of the expected additive activity, indicating synergistic interaction between the compounds.	Lycopene	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	124-128	
32126272-3	2020	Owing to its potent antioxidant properties, lycopene can potentially alleviate enhanced levels of proinflammatory mediators (e.g., proinflammatory cytokines IL-8, -6, and -1, and oxidized phospholipids) and prevent NF-kappaB activation by modulating oxidative stress.	Lycopene	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	157-173	
21625550-0	2011	Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37	
21625550-3	2011	The aim of this study was to investigate the role of lycopene on the production of the pro-inflammatory cytokine IL-8 induced by cigarette smoke and the possible mechanisms implicated.	Lycopene	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	113-117	
21625550-6	2011	Lycopene pre-treatment resulted in a significant inhibition of CSE-induced IL-8 expression at both mRNA and protein levels.	Lycopene	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	75-79	
21625550-13	2011	Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB.	Lycopene	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	38-42