PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27807077-4	2017	Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice.	Lycopene	17-25	beta-carotene oxygenase 2	Mus musculus	36-40	
29266812-1	2018	SCOPE: Beta-carotene-15,15"-oxygenase (BCO1) and beta-carotene-9",10"-oxygenase (BCO2) metabolize lycopene to biologically active metabolites, which can ameliorate nonalcoholic fatty liver disease (NAFLD).	Lycopene	98-106	beta-carotene oxygenase 2	Mus musculus	81-85	
34964896-9	2022	The impact of Bco2 genotype was limited to a subset of lycopene-impacted genes (Apc, Mto1, Nfkb1, and Rbm39).	Lycopene	55-63	beta-carotene oxygenase 2	Mus musculus	14-18	
27807077-4	2017	Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice.	Lycopene	17-25	beta-carotene oxygenase 2	Mus musculus	158-162	
27807077-7	2017	Overall, dietary tomato and lycopene inhibited the progression of prostate cancer in TRAMP in a Bco2 genotype-specific manner, potentially implicating the anticancer activity of lycopene cleavage products.	Lycopene	28-36	beta-carotene oxygenase 2	Mus musculus	96-100	
25293877-2	2014	We recently showed that apo-10"-lycopenoic acid, a lycopene metabolite generated by beta-carotene-9",10"-oxygenase (BCO2), inhibited carcinogen-initiated, high-fat diet (HFD)-promoted liver inflammation, and hepatic tumorigenesis development.	Lycopene	51-59	beta-carotene oxygenase 2	Mus musculus	116-120	
25644347-5	2015	RESULTS: Lycopene or APO10LA supplementation reduced hepatic steatosis incidence (78% and 72%, respectively) and severity in BCO2-KO male mice.	Lycopene	9-17	beta-carotene oxygenase 2	Mus musculus	125-129	
25644347-11	2015	CONCLUSIONS: Our data suggest that lycopene and APO10LA inhibit HSFD-induced steatosis in BCO2-KO male mice through differential mechanisms.	Lycopene	35-43	beta-carotene oxygenase 2	Mus musculus	90-94	
25293877-7	2014	Lycopene supplementation in BCO2-KO mice suppressed oncogenic signals, including Met mRNA, beta-catenin protein, and mTOR complex 1 activation, which was associated with increased hepatic microRNA (miR)-199a/b and miR214 levels.	Lycopene	0-8	beta-carotene oxygenase 2	Mus musculus	28-32	
25293877-8	2014	These results provided novel experimental evidence that dietary lycopene can prevent HFD-promoted HCC incidence and multiplicity in mice, and may elicit different mechanisms depending on BCO2 expression.	Lycopene	64-72	beta-carotene oxygenase 2	Mus musculus	187-191	
25293877-6	2014	In contrast, the protective effects of lycopene in BCO2-KO but not in wild-type mice were associated with reduced hepatic endoplasmic reticulum stress-mediated unfolded protein response (ER(UPR)), through decreasing ER(UPR)-mediated protein kinase RNA-activated like kinase-eukaryotic initiation factor 2alpha activation, and inositol requiring 1alpha-X-box-binding protein 1 signaling.	Lycopene	39-47	beta-carotene oxygenase 2	Mus musculus	51-55	
16672231-5	2006	The cleavage activity of ferret CMO2 was higher toward lycopene cis-isomers as compared with beta-carotene as substrate.	Lycopene	55-63	beta-carotene oxygenase 2	Mus musculus	32-36	
16672231-3	2006	Here we provide information on the biochemical characterization of CMO2 of the ferret, a model for human carotenoid metabolism, in terms of the kinetic analysis of beta-carotene/lycopene cleavage into beta-apo-10"-carotenal/apo-10"-lycopenal in vitro and the formation of apo-10"-lycopenoids in ferrets in vivo.	Lycopene	178-186	beta-carotene oxygenase 2	Mus musculus	67-71	
16672231-7	2006	Furthermore, all-trans-lycopene supplementation in ferrets resulted in significant accumulation of cis-isomers of lycopene and the formation of apo-10"-lycopenol, as well as up-regulation of the CMO2 expression in lung tissues.	Lycopene	13-31	beta-carotene oxygenase 2	Mus musculus	195-199	
16672231-7	2006	Furthermore, all-trans-lycopene supplementation in ferrets resulted in significant accumulation of cis-isomers of lycopene and the formation of apo-10"-lycopenol, as well as up-regulation of the CMO2 expression in lung tissues.	Lycopene	23-31	beta-carotene oxygenase 2	Mus musculus	195-199	
16672231-9	2006	Our finding of bioconversion of cis-isomers of lycopene into apo-10"-lycopenoids by CMO2 is significant because cis-isomers of lycopene are a predominant form of lycopene in mammalian tissues and apo-lycopenoids may have specific biological activities related to human health.	Lycopene	47-55	beta-carotene oxygenase 2	Mus musculus	84-88	
16672231-9	2006	Our finding of bioconversion of cis-isomers of lycopene into apo-10"-lycopenoids by CMO2 is significant because cis-isomers of lycopene are a predominant form of lycopene in mammalian tissues and apo-lycopenoids may have specific biological activities related to human health.	Lycopene	127-135	beta-carotene oxygenase 2	Mus musculus	84-88	
16672231-9	2006	Our finding of bioconversion of cis-isomers of lycopene into apo-10"-lycopenoids by CMO2 is significant because cis-isomers of lycopene are a predominant form of lycopene in mammalian tissues and apo-lycopenoids may have specific biological activities related to human health.	Lycopene	127-135	beta-carotene oxygenase 2	Mus musculus	84-88