PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30939781-0 2019 Lycopene Inhibits Reactive Oxygen Species-Mediated NF-kappaB Signaling and Induces Apoptosis in Pancreatic Cancer Cells. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 51-60 31491956-7 2019 Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 250-263 31491956-7 2019 Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 260-263 30939781-4 2019 The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-kappaB activation and expression of NF-kappaB target genes including cIAP1, cIAP2, and survivin. Lycopene 47-55 nuclear factor kappa B subunit 1 Homo sapiens 195-204 30939781-4 2019 The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-kappaB activation and expression of NF-kappaB target genes including cIAP1, cIAP2, and survivin. Lycopene 47-55 nuclear factor kappa B subunit 1 Homo sapiens 234-243 30939781-5 2019 The results show that the lycopene decreased intracellular and mitochondrial ROS levels, mitochondrial function (determined by the mitochondrial membrane potential and oxygen consumption rate), NF-kappaB activity, and expression of NF-kappaB-dependent survival genes in PANC-1 cells. Lycopene 26-34 nuclear factor kappa B subunit 1 Homo sapiens 194-203 30939781-5 2019 The results show that the lycopene decreased intracellular and mitochondrial ROS levels, mitochondrial function (determined by the mitochondrial membrane potential and oxygen consumption rate), NF-kappaB activity, and expression of NF-kappaB-dependent survival genes in PANC-1 cells. Lycopene 26-34 nuclear factor kappa B subunit 1 Homo sapiens 232-241 27155396-0 2016 Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 40-49 27406826-0 2016 Mitochondrial beta-Carotene 9",10" Oxygenase Modulates Prostate Cancer Growth via NF-kappaB Inhibition: A Lycopene-Independent Function. Lycopene 106-114 nuclear factor kappa B subunit 1 Homo sapiens 82-91 26779636-0 2016 Lycopene acts through inhibition of IkappaB kinase to suppress NF-kappaB signaling in human prostate and breast cancer cells. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 63-72 26779636-1 2016 We studied the effect of the potent dietary antioxidant lycopene on multiple points along the nuclear factor kappa B (NF-kappaB) signaling pathway in prostate and breast cancer cells. Lycopene 56-64 nuclear factor kappa B subunit 1 Homo sapiens 94-116 26779636-1 2016 We studied the effect of the potent dietary antioxidant lycopene on multiple points along the nuclear factor kappa B (NF-kappaB) signaling pathway in prostate and breast cancer cells. Lycopene 56-64 nuclear factor kappa B subunit 1 Homo sapiens 118-127 26779636-4 2016 Furthermore, the same degree of inhibition by lycopene was observed for NF-kappaB transcriptional activity, as determined by reporter gene assay. Lycopene 46-54 nuclear factor kappa B subunit 1 Homo sapiens 72-81 26779636-5 2016 Concomitant with this, immunofluorescence staining of lycopene-treated cells showed a significant suppression (>=25 %) of TNF-induced NF-kappaB p65 subunit nuclear translocation. Lycopene 54-62 nuclear factor kappa B subunit 1 Homo sapiens 137-146 26779636-6 2016 Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene. Lycopene 19-27 nuclear factor kappa B subunit 1 Homo sapiens 66-75 26779636-6 2016 Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene. Lycopene 294-302 nuclear factor kappa B subunit 1 Homo sapiens 66-75 26779636-7 2016 In conclusion, the anticancer properties of lycopene may occur through inhibition of the NF-kappaB signaling pathway, beginning at the early stage of cytoplasmic IKK kinase activity, which then leads to reduced NF-kappaB-responsive gene regulation. Lycopene 44-52 nuclear factor kappa B subunit 1 Homo sapiens 89-98 26779636-7 2016 In conclusion, the anticancer properties of lycopene may occur through inhibition of the NF-kappaB signaling pathway, beginning at the early stage of cytoplasmic IKK kinase activity, which then leads to reduced NF-kappaB-responsive gene regulation. Lycopene 44-52 nuclear factor kappa B subunit 1 Homo sapiens 211-220 27155396-16 2016 SIGNIFICANCE: The Nrf2-regulated antioxidant property plays a pivotal role in the anti-inflammatory mechanism underlying the inhibition of NF-kappaB activation in lycopene-treated ARPE-19 cells. Lycopene 163-171 nuclear factor kappa B subunit 1 Homo sapiens 139-148 28386381-10 2017 The protein expressions of NF-kappaB and JNK were decreased significantly according to lycopene concertation (P < 0.05). Lycopene 87-95 nuclear factor kappa B subunit 1 Homo sapiens 27-36 28386381-11 2017 CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells. Lycopene 13-21 nuclear factor kappa B subunit 1 Homo sapiens 32-41 27155396-10 2016 Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-kappaB activation for up to 12h in TNFalpha-treated RPE cells. Lycopene 13-21 nuclear factor kappa B subunit 1 Homo sapiens 63-72 21487789-5 2011 Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4). Lycopene 30-38 nuclear factor kappa B subunit 1 Homo sapiens 126-147 24020124-4 2013 Also, lycopene increased KLF2 expression, while it inhibited the activation TLR4 and its downstream ERK and the NF-kappaB signaling pathway in HUVECs. Lycopene 6-14 nuclear factor kappa B subunit 1 Homo sapiens 112-121 21487789-5 2011 Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4). Lycopene 30-38 nuclear factor kappa B subunit 1 Homo sapiens 149-158 21487789-6 2011 CONCLUSION: These findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-kappaB, CD14 and TLR4 expression and production of TNF-alpha, thereby endorsing its usefulness as therapy for vascular inflammatory diseases. Lycopene 40-48 nuclear factor kappa B subunit 1 Homo sapiens 187-196 21484151-10 2011 Lycopene inhibited the cerulein-induced increase in intracellular ROS, NF-kappaB activation, and IL-6 expression in pancreatic acinar cells in a dose-dependent manner. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 71-80 20952175-9 2011 In transient transfections, a decrease of the luciferase gene reporter under control of NF-kappaB responsive element was observed for cells incubated in the presence of lycopene and TNFalpha compared to TNFalpha alone. Lycopene 169-177 nuclear factor kappa B subunit 1 Homo sapiens 88-97 20952175-10 2011 The involvement of the NF-kappaB pathway was confirmed by the modulation of IKKalpha/beta phosphorylation by lycopene. Lycopene 109-117 nuclear factor kappa B subunit 1 Homo sapiens 23-32 21484151-11 2011 In conclusion, lycopene may be beneficial in the prevention and/or treatment of acute pancreatitis by inhibiting the activation of NF-kappaB and the expression of inflammatory cytokines through reduction in intracellular levels of ROS in pancreatic acinar cells. Lycopene 15-23 nuclear factor kappa B subunit 1 Homo sapiens 131-140 20573495-0 2011 Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 110-119 18439578-10 2008 Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases. Lycopene 65-73 nuclear factor kappa B subunit 1 Homo sapiens 111-120 18439578-6 2008 A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus. Lycopene 34-42 nuclear factor kappa B subunit 1 Homo sapiens 97-106 18439578-6 2008 A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus. Lycopene 34-42 nuclear factor kappa B subunit 1 Homo sapiens 123-132 18439578-7 2008 In line with this, TNF-alpha-induced NF-kappaB-DNA but not AP1-DNA complexes formation was inhibited by lycopene, as determined by the electrophoretic mobility shift assay (EMSA). Lycopene 104-112 nuclear factor kappa B subunit 1 Homo sapiens 37-46 17049831-0 2007 Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 99-121 17049831-7 2007 Lycopene also significantly inhibited the binding abilities of NF-kappaB and Sp1 and decreased, to some extent, the expression of insulin-like growth factor-1 receptor (IGF-1R) and the intracellular level of reactive oxygen species (P<.05). Lycopene 0-8 nuclear factor kappa B subunit 1 Homo sapiens 63-72 17049831-9 2007 Thus, lycopene decreases the invasive ability of SK-Hep-1 cells by inhibiting MMP-9 expression and suppressing the binding activity of NF-kappaB and Sp1. Lycopene 6-14 nuclear factor kappa B subunit 1 Homo sapiens 135-144