PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11489752-11 2001 Expression of connexin 43 in cancerous prostate tissue was 0.63 +/- 0.19 absorbance in the lycopene group compared with 0.25 +/- 0.08 in the control group (P = 0.13). Lycopene 91-99 gap junction protein alpha 1 Homo sapiens 14-25 32708354-7 2020 Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05). Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 91-102 10620348-2 2000 Lycopene, a nonprovitamin A carotenoid and its possible oxidation product, acyclo-retinoic acid, were tested for their effect on GJC, on stabilization of connexin43 mRNA, and on the transactivation of the RAR-beta2-promoter in vitro. Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 154-164 32708354-7 2020 Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05). Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 104-108 17438348-0 2007 Immunohistochemical expression of RARalpha, RARbeta, and Cx43 in breast tumor cell lines after treatment with lycopene and correlation with RT-QPCR. Lycopene 110-118 gap junction protein alpha 1 Homo sapiens 57-61 12968069-6 2003 We report that in this cell line, lycopene has a potentially unwanted effect of upregulating expression of the urokinase plasminogen activator receptor and facilitating invasion while failing to significantly inhibit proliferation or to induce detectable levels of the gap junctional protein connexin 43 expression. Lycopene 34-42 gap junction protein alpha 1 Homo sapiens 292-303 17140762-7 2007 The induction of GJIC by lycopene was confirmed by an increased expression of connexin 43. Lycopene 25-33 gap junction protein alpha 1 Homo sapiens 78-89 12468619-7 2002 Lycopene (3 and 7 micro mol/L) significantly upregulated both the transcription (P < 0.005) and the expression (P < 0.05) of connexin 43, a key protein in the formation of gap-junctional communication. Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 131-142 15087273-3 2003 Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high. Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 194-205 15087273-3 2003 Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high. Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 207-212 15087273-3 2003 Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high. Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 356-361 15087273-6 2003 Lycopene induced Cx-43 expression in KB-1 cells grown by the organotypic raft method, similar to KB-1 cells grown as monolayers. Lycopene 0-8 gap junction protein alpha 1 Homo sapiens 17-22 12424335-7 2002 Studies using human and animal cells have identified a gene, connexin 43, whose expression is upregulated by lycopene and which allows direct intercellular gap junctional communication (GJC). Lycopene 109-117 gap junction protein alpha 1 Homo sapiens 61-72